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Radiofrequency thermal ablation of liver tumors

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Abstract

Radiofrequency ablation (RFA) of liver tumors was first proposed in 1990. New technologies enable us to produce liver thermal lesions of approximately 3–3.5 cm in diameter; RFA has consequently become an emerging percutaneous therapeutic option both for small hepatocellular carcinoma (HCC) and for non-resectable liver metastases, mainly from colorectal cancer. New devices (for example, triplet of cooled needles, wet needles) and combined therapies (tumor ischemia and RFA) have made it possible to treat large tumors. RFA can be carried out by a percutaneous, laparoscopic or laparotomic approach. Percutaneous RFA can be performed with local anaesthesia and mild sedation; deep sedation or general anaesthesia are also used. The guidance system is generally represented by ultrasound. CT or MR examinations are the more sensitive tests for assessing therapeutic results. The series of patients treated with RFA allow the technique to be considered as effective and safe, achieving a relatively high rate of cure in properly selected cases; it should be classified as curative/effective treatment for HCC, replacing percutaneous ethanol injection. The complication rate of RFA is low but not negligible; key elements in a strategy to minimize them are identified.

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Acknowledgements

Authors wish to thank Mrs. Letizia Bottelli, in charge of the Library of Maggiore Hospital in Crema, for her dedication and support in the bibliographic search.

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Authors and Affiliations

  1. Gastroenterology Department, Maggiore Hospital, Via Macallé 1, 26013, Crema, Italy

    Elisabetta Buscarini, Gianfranco Brambilla, Fernanda Menozzi & Alessandro Zambelli

  2. Department of Surgery II, Maggiore Hospital, Crema, Italy

    Agostino Savoia & Luigi Gaiti

  3. Department of Radiology, Maggiore Hospital, Crema, Italy

    Luigi Reduzzi

  4. Department of Medicine I, University of Erlangen, Erlangen, Germany

    Deike Strobel & Johannes Hänsler

  5. Department of Gastroenterology, General Hospital, Piacenza, Italy

    Luigi Buscarini

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  1. Elisabetta Buscarini
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Correspondence to Elisabetta Buscarini.

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Buscarini, E., Savoia, A., Brambilla, G. et al. Radiofrequency thermal ablation of liver tumors. Eur Radiol 15, 884–894 (2005). https://doi.org/10.1007/s00330-005-2652-x

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