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Detection of colorectal liver metastases: a prospective multicenter trial comparing unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT

  • Hepatobiliary–Pancreas
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Abstract

The aim of this study was to compare unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT in the detection of hepatic colorectal metastases. Forty-four patients with hepatic colorectal metastases were examined with unenhanced and MnDPDP-enhanced MRI and with unenhanced and contrast-enhanced spiral CT. The MR examination protocol included baseline T1-weighted spin-echo (SE), T1-weighted gradient-recalled-echo (GRE), and T2-weighted fast-SE sequences; and T1-weighted SE and T1-weighted GRE sequences obtained 30–60 min after administration of 0.5 µmol/kg (0.5 ml/kg) mangafodipir trisodium (MnDPDP). Images were interpreted by three blinded readers. Findings at CT and MRI were compared with those at intraoperative US, which were used as term of reference. Intraoperative US detected 128 metastases. In a lesion-by-lesion analysis, the overall detection rate was 71% (91 of 128) for spiral CT, 72% (92 of 128) for unenhanced MRI, and 90% (115 of 128) for MnDPDP-enhanced MRI. MnDPDP-enhanced MRI was more sensitive than either unenhanced MRI (p<0.0001) or spiral CT (p=0.0007). In a patient-by-patient analysis, agreement with gold standard was higher for MnDPDP-enhanced MRI (33 of 44 cases) than for spiral CT (22 of 44 cases, p=0.0023) and unenhanced MRI (21 of 44 cases, p=0.0013). MnDPDP-enhanced MRI is superior to unenhanced MRI and spiral CT in the detection of hepatic colorectal metastases.

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Authors and Affiliations

  1. Department of Radiology, University of Pisa, Via Roma 67, 56100, Pisa, Italy

    Carlo Bartolozzi, Francescamaria Donati, Dania Cioni & Riccardo Lencioni

  2. Department of Radiology, University of Verona, Piazzale L.A. Scuro 1, 37134, Verona, Italy

    Carlo Procacci & Giovanni Morana

  3. Department of Radiology, University of Brescia, Piazzale Spedali Civili 1, 25023, Brescia, Italy

    Antonio Chiesa & Luigi Grazioli

  4. Department of Radiology, University of Genova, Largo R. Benzi 10, 16132, Genova, Italy

    Giorgio Cittadini, Giorgio Cittadini, Giuseppe Cittadini & Giuseppe Cittadini

  5. Department of Radiology, University of Ancona, Concam, Torrette, 60020, Ancona, Italy

    Andrea Giovagnoni

  6. Department of Radiology, University of Torino, Genova 3, 10110, Torino, Italy

    Giovanni Gandini & Jochen Maass

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  1. Carlo Bartolozzi
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  2. Francescamaria Donati
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  13. Riccardo Lencioni
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Correspondence to Carlo Bartolozzi.

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Bartolozzi, C., Donati, F., Cioni, D. et al. Detection of colorectal liver metastases: a prospective multicenter trial comparing unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT. Eur Radiol 14, 14–20 (2004). https://doi.org/10.1007/s00330-003-1966-9

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  • DOI: https://doi.org/10.1007/s00330-003-1966-9

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