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Impact of obesity on quality of life, psychological status, and disease activity in psoriatic arthritis: a multi‑center study

  • Observational Research
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Abstract

This article aims to evaluate the possible effect of obesity on quality of life, psychological status, and other clinical variables in Psoriatic arthritis (PsA). PsA patients have been recruited by the Turkish League Against Rheumatism-Network from various centers in Turkey in this cross-sectional study. Patients with a body mass index (BMI) ≥ of 30 kg/m2 were considered obese. Differences among patients with regard to obesity status were assessed with health-related quality of life measures (PsA Quality of Life Questionnaire [PsAQoL]), psychological status (Hospital Anxiety and Depression Scale [HADS]), and disease activity parameters (the Disease Activity index for PSoriatic Arthritis [DAPSA], Disease Activity Score 28-C-reactive protein [DAS28-CRP], Bath Ankylosing Spondylitis Disease Activity Index [BASDAI], Psoriasis Area and Severity Index [PASI]), physical functions (Ankylosing Spondylitis Functional Index [BASFI], Health Assessment Questionnaire [HAQ], and Health Assessment Questionnaire for the spondyloarthropathies [HAQ-S]). Pain was assessed using visual analog scale of pain (VAS-P), and fatigue was evaluated using visual analog scale of fatigue (VAS-F) and Functional Assessment of Chronic Illness Therapy (FACIT). A total of 1033 patients with PsA, 650 (62.9%) non-obese and 383 (37.1%) obese were included in the study. The PsAQoL, HADS-Anxiety, HADS-Depression, DAPSA, DAS28-CRP, BASDAI, BASFI, HAQ and HAQ-S scores of the obese group were higher than the non-obese group (p < 0.05). VAS-P and PASI scores were similar between group of patients with and without obesity. Obese patients had higher median scores of VAS-F and FACIT than non-obese patients (p < 0.05). Linear regression analysis showed that BMI affects the quality of life, depression, and disease activity. Consequently, obesity has significant associations with higher disease activity, lower QoL, risk of anxiety, depression, and fatigue. Therefore, obesity should also be taken into account in the management of PsA patients.

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Authors and Affiliations

  1. Rheumatology Clinic, Ankara City Hospital, Ankara, Turkey

    Kevser Gok

  2. Division of Rheumatology and Immunology, Department of Physical Medicine and Rehabilitation, Sakarya University School of Medicine, Sakarya, Turkey

    Kemal Nas, Ibrahim Tekeoglu & Ayhan Kamanli

  3. Rheumatology Clinic, Aydın State Hospital, Aydın, Turkey

    Ismihan Sunar

  4. Department of Physical Medicine and Rehabilitation, Bezmiâlem Vakif University, İstanbul, Turkey

    Yasar Keskin, Okan Kucukakkas & Ozan Volkan Yurdakul

  5. Rheumatology Clinic, Kanuni Training and Research Hospital, Trabzon, Turkey

    Erkan Kilic

  6. Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Adnan Menderes University School of Medicine, Aydın, Turkey

    Betul Sargin

  7. Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Marmara University School of Medicine, İstanbul, Turkey

    Sevtap Acer Kasman & Mehmet Tuncay Duruoz

  8. Department of Physical Medicine and Rehabilitation, Pamukkale University School of Medicine, Denizli, Turkey

    Hakan Alkan

  9. Department of Physical Medicine and Rehabilitation, Balıkesir University School of Medicine, Balıkesir, Turkey

    Nilay Sahin

  10. Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Erciyes University School of Medicine, Kayseri, Turkey

    Gizem Cengiz & Mustafa Calis

  11. Rheumatology Clinic, Balıkesir Atatürk City Hospital, Balıkesir, Turkey

    Nihan Cuzdan

  12. Department of Physical Medicine and Rehabilitation, Selçuk University School of Medicine, Konya, Turkey

    İlknur Albayrak Gezer

  13. Department of Physical Medicine and Rehabilitation, Kırıkkale University School of Medicine, Kırıkkale, Turkey

    Dilek Keskin

  14. Department of Physical Medicine and Rehabilitation, Ankara Training and Research Hospital, Ankara, Turkey

    Cevriye Mulkoglu

  15. Department of Physical Medicine and Rehabilitation, Çanakkale Onsekiz Mart University School of Medicine, Çanakkale, Turkey

    Hatice Resorlu

  16. Department of Physical Medicine and Rehabilitation, University of Health Sciences Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

    Ajda Bal

  17. Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Atatürk University School of Medicine, Erzurum, Turkey

    Meltem Alkan Melikoglu

  18. Department of Physical Medicine and Rehabilitation, Tekirdağ Kapaklı State Hospital, Tekirdağ, Turkey

    Yildiray Aydin

  19. Department of Physical Medicine and Rehabilitation, Atilim University Medical School, Ankara, Turkey

    Fikriye Figen Ayhan

  20. Department of Physical Medicine and Rehabilitation, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey

    Hatice Bodur

  21. Department of Physical Medicine and Rehabilitation, Karadeniz Technical University School of Medicine, Trabzon, Turkey

    Erhan Capkin

  22. Department of Physical Medicine and Rehabilitation, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey

    Gul Devrimsel

  23. Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey

    Hilal Ecesoy

  24. Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Cumhuriyet University School of Medicine, Sivas, Turkey

    Sami Hizmetli

  25. Rheumatology Clinic, Antalya Training and Research Hospital, Antalya, Turkey

    Oznur Kutluk

  26. Rheumatology Clinic, Kartal Dr. Lutfi Kirdar Training and Research Hospital, İstanbul, Turkey

    Nesrin Sen

  27. Department of Physical Medicine and Rehabilitation and Algology, Medicana International Hospital, İzmir, Turkey

    Omer Faruk Sendur

  28. Department of Physical Medicine and Rehabilitation, Medipol University School of Medicine, Istanbul, Turkey

    Sena Tolu

  29. Department of Physical Medicine and Rehabilitation, Yuzuncu Yıl University School of Medicine, Van, Turkey

    Murat Toprak

  30. Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Akdeniz University School of Medicine, Antalya, Turkey

    Tiraje Tuncer

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  1. Kevser Gok
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  2. Kemal Nas
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  18. Mehmet Tuncay Duruoz
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  19. Okan Kucukakkas
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  20. Ozan Volkan Yurdakul
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  25. Mustafa Calis
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  26. Erhan Capkin
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  27. Gul Devrimsel
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  28. Hilal Ecesoy
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Contributions

All authors have contributions to the study conception, design and data collection. Literature search was performed by KG. Analysis and interpretation of data were performed by KG, KN, IT, IS, and YK. The first draft of the manuscript was written by KG. KG, KN, IT, and YK participated in drafting and revise the work. All authors commented on previous versions of the manuscript and have approved the final version of the manuscript. KN had full access to all of the data in the study and takes responsibility for the integrity of the data. All co-authors are fully accountable for all aspects of the work and the final manuscript in line with the IJME 4 criteria.

Corresponding author

Correspondence to Kevser Gok.

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Authors declare no conflict of interest.

Ethical approval

Ethical approval was taken from the Sakarya University Ethics Committee on 25.01.2018. The protocol number was 42 and conducted in accordance with the Helsinki Declaration.

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Gok, K., Nas, K., Tekeoglu, I. et al. Impact of obesity on quality of life, psychological status, and disease activity in psoriatic arthritis: a multi‑center study. Rheumatol Int 42, 659–668 (2022). https://doi.org/10.1007/s00296-021-04971-8

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  • DOI: https://doi.org/10.1007/s00296-021-04971-8

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