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Analysis of the data on pregnancy and lactation provided by patient information leaflets of anti-rheumatic drugs in Argentina

  • Pharmacovigilance
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Abstract

To analyse the level of consistency and updating of the information on pregnancy and lactation provided by patient information leaflets (PILs) of the antirheumatic drugs approved in Argentina. Inconsistencies between the 2016 EULAR Task Force recommendations on the use of anti-rheumatic drugs during pregnancy and lactation and the information provided by PILs of the same drugs approved in Argentina were analysed along with inconsistencies within the PILs of different registered trademarks of these drugs. Eighty-eight PILs of 32 drugs were analysed. Out of the 88 PILs, 50% presented information inconsistencies as to pregnancy. Medications comprised in this group were: hydroxychloroquine, sulfasalazine, azathioprine, tacrolimus, cyclosporine, NSAIDs (during the first two trimesters), celecoxib, some glucocorticoids, colchicine, and some anti-TNF drugs (etanercept, adalimumab and infliximab) during part of the pregnancy. As for lactation, 56% had information inconsistencies. Medications encompassed in this group were: hydroxychloroquine, chloroquine, sulfasalazine, azathioprine, tacrolimus, cyclosporine, NSAIDs, celecoxib, meprednisone, prednisone, colchicine, and anti-TNF drugs. Out of 17 drugs that had more than one registered trademark, information inconsistencies on pregnancy were found in the PILs of sulfasalazine, diclofenac, ibuprofen and methylprednisolone. Concerning lactation, inconsistencies were present in the PILs of hydroxychloroquine, sulfasalazine, diclofenac, ibuprofen, meprednisone, and colchicine. At least half of the PILs of anti-rheumatic drugs analysed in this study had information inconsistencies on pregnancy and lactation. This is a serious state of affairs because the consensual decision-making process between patient and professional may be compromised, which, in turn, may give rise to medical-legal issues.

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Funding

This research received no specific Grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Servicio de Reumatología, Hospital J. M. Ramos Mejía, Urquiza 609, ZIP 1221, Ciudad Autónoma de Buenos Aires, Argentina

    Miguel Ormaza Sabando, Maira Arias Saavedra, Gabriel Sequeira & Eduardo Kerzberg

Authors
  1. Miguel Ormaza Sabando
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  2. Maira Arias Saavedra
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  3. Gabriel Sequeira
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  4. Eduardo Kerzberg
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Corresponding author

Correspondence to Gabriel Sequeira.

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The authors declare no conflict of interest.

Additional information

This study was presented as a poster at the 50th Argentine Congress of Rheumatology that took place in Rosario, Argentina, 11–14 October 2017. It has not been published or submitted for publication elsewhere.

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Sabando, M.O., Saavedra, M.A., Sequeira, G. et al. Analysis of the data on pregnancy and lactation provided by patient information leaflets of anti-rheumatic drugs in Argentina. Rheumatol Int 38, 669–673 (2018). https://doi.org/10.1007/s00296-018-3931-6

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  • DOI: https://doi.org/10.1007/s00296-018-3931-6

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