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Osteoanabolic therapy: a non-surgical option of treatment for Kümmell’s disease?

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Abstract

Kümmell’s disease is the current eponym of avascular osteonecrosis (AVN) of a vertebral body leading to a delayed non-healing vertebral compression fracture (VCF) and thus pseudo-arthrosis. AVN is characterized by production of gas that outlines a radiolucent zone in the vertebral body, called vacuum cleft sign (VCS) or “Kümmell’s sign”. This sign has been observed in up to one-third of VCFs and is often associated with osteoporosis and never with malignant or inflammatory diseases. Generally, treatment strategies are conservative management and percutaneous vertebroplasty. Teriparatide (rhPTH [1-34]) is an osteoanabolic agent approved for treatment of osteoporosis and helpful in fracture’s healing too. Here, we describe the case of an 81-year-old osteoporotic woman presented with a 1-year history of persistent low back pain onset after a trauma. A lumbar spine Computer Tomography (CT) scan performed 2 months after the injury (November 2006) showed the VCS within a VCF of the first lumbar vertebra; a control CT scan 1 year later showed persistence of the finding. After 12 months of treatment with teriparatide 20 mcg/day, symptoms disappeared and vacuum was significantly reduced. In conclusion, Kümmell’s disease may be hypothesized in patients with chronic spinal symptoms, especially in the presence of osteoporosis. Moreover in this condition, osteoanabolic treatment may be used in patients with Kümmell’s disease to enhance vertebral fracture’s healing and contribute to back pain relief.

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Authors and Affiliations

  1. Institute of Internal Medicine, Angiology and Arteriosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Piazzale Menghini, 1, 06129, Perugia, Italy

    Gianluigi Fabbriciani, Matteo Pirro, Laura Callarelli, Maria Rosaria Manfredelli, Anna Maria Scarponi & Elmo Mannarino

  2. Institute of Neuroradiology, Hospital “Santa Maria della Misericordia”, Perugia, Italy

    Piero Floridi

Authors
  1. Gianluigi Fabbriciani
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  2. Matteo Pirro
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  3. Piero Floridi
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  4. Laura Callarelli
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  5. Maria Rosaria Manfredelli
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  6. Anna Maria Scarponi
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  7. Elmo Mannarino
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Correspondence to Gianluigi Fabbriciani.

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Fabbriciani, G., Pirro, M., Floridi, P. et al. Osteoanabolic therapy: a non-surgical option of treatment for Kümmell’s disease?. Rheumatol Int 32, 1371–1374 (2012). https://doi.org/10.1007/s00296-010-1408-3

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  • DOI: https://doi.org/10.1007/s00296-010-1408-3

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