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Correlation between Yersinia enterocolitica and type I collagen reactivity in patients with arthropathies

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Abstract

We investigated the association with Yersinia infection in patients with arthropathies in our region. To assess the reactivity to articular antigens, the correlation of anti-Yersinia with anti-type I and type II collagen antibodies was studied. Sera from 124 patients with musculoskeletal symptoms, and 47 synovial fluids (SF) from patients with rheumatoid arthritis (RA), spondyloarthopathies (SpA) or osteoarthritis (OA) were examined. Immunoglobulins against Yersinia enterocolitica, type I and type II collagens were determined by enzyme-linked immunosorbent assay. Immunoglobulin (Ig) A to Yersinia lipopolysaccharide (LPS) was present in 13/124 sera (10%) and 3/47 SF (6%). By Western blot, IgA to Yersinia outer proteins (Yops) was found in 14/124 sera (11%) and 2/47 SF (4%). Yersinia DNA from SF was not amplified by polymerase chain reaction. We found a significant correlation with anti-collagen type I but not type II antibodies. These results suggest different reactivity to articular collagen in patients with Yersinia antibodies.

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Acknowledgment

This study was supported by the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET, PIP 6224) and Universidad Nacional de San Luis (Proj. 0401 and 8803). Silvia Di Genaro and Silvia G. Correa are member career, and Gabriela Lacoste fellow of CONICET.

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Authors and Affiliations

  1. Laboratory of Microbiology; Chemistry, Biochemistry and Pharmacy Faculty, National University of San Luis, Chacabuco y Pedernera, San Luis, 5700, Argentina

    María G. Lacoste, Ana M. S. de Guzmán & María S. Di Genaro

  2. Public Hospital of San Luis, Héroes de Malvinas 110, San Luis, 5700, Argentina

    Héctor Tamashiro

  3. Immunology, CIBICI (CONICET) Faculty of Chemical Science, National University of Córdoba, Córdoba, 5500, Argentina

    Silvia G. Correa

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  1. María G. Lacoste
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  2. Héctor Tamashiro
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  4. Ana M. S. de Guzmán
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  5. María S. Di Genaro
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Correspondence to María S. Di Genaro.

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Lacoste, M.G., Tamashiro, H., Correa, S.G. et al. Correlation between Yersinia enterocolitica and type I collagen reactivity in patients with arthropathies. Rheumatol Int 27, 613–620 (2007). https://doi.org/10.1007/s00296-006-0274-5

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  • DOI: https://doi.org/10.1007/s00296-006-0274-5

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