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Die Nested-Variante des Urothelkarzinoms

Fallbericht und molekulare Aspekte

Nested-variant urothelial carcinoma

Case report and molecular aspects

  • Schwerpunkt: Uropathologie
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Zusammenfassung

Die Nested-Variante des Urothelkarzinoms ist eine seltene Form des Urothelkarzinoms, die sich durch blande Morphologie und durch frühes muskelinvasives Wachstum auszeichnet. Wir berichten über einen 65-jährigen Patienten, bei dem eine nichtinvasive „High-grade-Urothelläsion“ (Carcinoma in situ und pTa „high grade“) festgestellt wurde. Nach BCG-Therapie fand sich ein invasives Urothelkarzinoms bei Fehlen von Carcinoma-in-situ-Läsionen. Anhand des Harnblasenresektats wurde die Diagnose eines Urothelkarzinoms, Nested-Variante, gestellt. Molekularbiologische Untersuchungen lassen eine De-novo-Entstehung des invasiven Urothelkarzinoms annehmen.

Abstract

The nested variant of urothelial carcinoma is a rare urothelial neoplasia which is characterized by relatively bland morphology and early muscle-invasive growth. We report on a 65-year-old male patient with a non-invasive high-grade urothelial lesion (carcinoma in situ and pTa G3). After treatment with BCG an invasive urothelial carcinoma was discovered whereas the carcinoma in situ had disappeared. Examination of the bladder specimen showed a nested-variant urothelial carcinoma. Molecular analyses indicated a de-novo genesis of the invasive urothelial carcinoma.

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Authors and Affiliations

  1. Universitätsklinikum Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland

    K. Lindemann-Docter, S.V. Koufou, E. Dahl, G. Jakse & R. Knüchel

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  1. K. Lindemann-Docter
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  2. S.V. Koufou
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  3. E. Dahl
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  4. G. Jakse
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  5. R. Knüchel
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Correspondence to K. Lindemann-Docter.

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Lindemann-Docter, K., Koufou, S., Dahl, E. et al. Die Nested-Variante des Urothelkarzinoms. Pathologe 29, 383–387 (2008). https://doi.org/10.1007/s00292-008-1018-y

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  • DOI: https://doi.org/10.1007/s00292-008-1018-y

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