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Green synthesis of chitosan-silver nanocomposite reinforced with curcumin nanoparticles: characterization and antibacterial effect

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Abstract

There has been significant interest to finding new and effective bactericidal materials due to increasing antibiotic resistance. Herein, this work reports on the design of a chitosan nanocomposite (NC) with two nanoparticle (NP) components, silver (Ag) and curcumin nanoparticles (Cur-NPs) with enhanced antibacterial activity. Chitosan-silver curcumin NC (Chi-Ag Cur NC) was prepared by adding water-soluble Cur-NPs to Chi-Ag NC solution. In order to produce Chi-Ag NC in a green manner, silver nanoparticles (Ag-NPs) were synthesized through photochemical reduction by using chitosan as the stabilizing agent and acetic acid as the reducing agent. The characteristics of Chi-Ag Cur NC were investigated through UV–Vis spectroscopy, FTIR, XRD, EDX, SEM, and DLS analysis. Chi-Ag Cur NC's antibacterial activity was further tested against certain clinically isolated strains of burn wound infection with significant antibiotic resistance as well as some standard bacterial strains. An increase in antimicrobial/antibiofilm activity of Chi-Ag Cur NC was observed with lower MIC and MBIC. In addition, no cytotoxicity of freshly produced NC was seen in NHDF cells. These results clearly revealed the synergy of Ag-NPs and Cur-NPs in novel antibacterial NC film which can be applicable as a promising antibacterial coating to prevent infection and promote burn wound healing.

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Acknowledgements

The authors would like to thank from the colleagues of Microbiology Laboratories of Alzahra University, Tehran, Iran.

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Authors and Affiliations

  1. Department of Microbiology, Faculty of Biosciences, Alzahra University, Tehran, Iran

    Zahra Rajabloo, Elahe Mobarak Qamsari & Rouha Kasra Kermanshahi

  2. Department of Chemistry, Faculty of Physics & Chemistry, Alzahra University, Tehran, Iran

    Faezeh Farzaneh

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  1. Zahra Rajabloo
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  2. Elahe Mobarak Qamsari
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  3. Rouha Kasra Kermanshahi
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  4. Faezeh Farzaneh
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Contributions

ZR: Investigation; Methodology, Resources. EMQ: Writing—original draft, Writing—review & editing. RKK: Project administration, Methodology, Supervision. FF: Methodology, Supervision, Resources.

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Correspondence to Rouha Kasra Kermanshahi.

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Rajabloo, Z., Mobarak Qamsari, E., Kasra Kermanshahi, R. et al. Green synthesis of chitosan-silver nanocomposite reinforced with curcumin nanoparticles: characterization and antibacterial effect. Polym. Bull. 80, 5333–5352 (2023). https://doi.org/10.1007/s00289-022-04270-7

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  • DOI: https://doi.org/10.1007/s00289-022-04270-7

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