Conclusions
A balance between epithelial growth and repair versus inflammation to isolate and contain damage is critical for maintenance of the epithelial microenvironment. Epithelial γδ T cells appear to play an important role in maintaining the integrity of the epithelial tissues they survey. Insult to the epithelium likely leads to the up-regulation of self-associated stress molecules that are recognized by intraepithelial γδ T cells. The limited, and in some cases canonical, repertoire of the epithelial γδ TCRs is certainly consistent with this recognition of damaged self, rather than recognition of the vast array of possible non-self antigens that could invade these epithelial barriers. Furthermore, the cellular context of the various γδ T cell subsets and the types of antigens they engage together may contribute to the distinct requirements of γδ T cells for PTKs in their selection, homing and presumably also in their response to epithelial cell damage.
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Witherden, D.A., Rieder, S.E., Boismenu, R. et al. A role for epithelial γδ T cells in tissue repair. Springer Semin Immunopathol 22, 265–281 (2000). https://doi.org/10.1007/s002810000045
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DOI: https://doi.org/10.1007/s002810000045