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Potential therapeutic value of TRPV1 and TRPA1 in diabetes mellitus and obesity

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Abstract

Diabetes mellitus and obesity, which is a major risk factor in the development of type 2 diabetes mellitus, have reached epidemic proportions worldwide including the USA. The current statistics and forecasts, both short- and long-term, are alarming and predict severe problems in the near future. Therefore, there is a race for developing new compounds, discovering new receptors, or finding alternative solutions to prevent and/or treat the symptoms and complications related to obesity and diabetes mellitus. It is well demonstrated that members of the transient receptor potential (TRP) superfamily play a crucial role in a variety of biological functions both in health and disease. In the recent years, transient receptor potential vanilloid type 1 (TRPV1) and transient receptor potential ankyrin 1 (TRPA1) were shown to have beneficial effects on whole body metabolism including glucose homeostasis. TRPV1 and TRPA1 have been associated with control of weight, pancreatic function, hormone secretion, thermogenesis, and neuronal function, which suggest a potential therapeutic value of these channels. This review summarizes recent findings regarding TRPV1 and TRPA1 in association with whole body metabolism with emphasis on obese and diabetic conditions.

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Acknowledgments

The authors acknowledge funding support from the National Institutes of Health (R01 DK099598 for AZs and HL122829 for AVD).

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Physiology, School of Medicine, Tulane University, 1430 Tulane Ave., New Orleans, LA, 70112, USA

    Andrei V. Derbenev & Andrea Zsombok

  2. Department of Medicine, Endocrinology Section, School of Medicine, Tulane University, 1430 Tulane Ave., New Orleans, LA, 70112, USA

    Andrea Zsombok

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Correspondence to Andrea Zsombok.

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This article is a contribution to the Special Issue on the Role of TRP Ion Channels in Physiology and Pathology - Guest Editor: Armen Akopian

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Derbenev, A.V., Zsombok, A. Potential therapeutic value of TRPV1 and TRPA1 in diabetes mellitus and obesity. Semin Immunopathol 38, 397–406 (2016). https://doi.org/10.1007/s00281-015-0529-x

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