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Taking the lymphatic route: dendritic cell migration to draining lymph nodes

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Abstract

In contrast to leukocyte migration through blood vessels, trafficking via lymphatic vessels (LVs) is much less well characterized. An important cell type migrating via this route is antigen-presenting dendritic cells (DCs), which are key for the induction of protective immunity as well as for the maintenance of immunological tolerance. In this review, we will summarize and discuss current knowledge of the cellular and molecular events that control DC migration from the skin towards, into, and within LVs, followed by DC arrival and migration in draining lymph nodes. Finally, we will discuss potential strategies to therapeutically target this migratory step to modulate immune responses.

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Acknowledgments

This work was supported by the Swiss National Science Foundation (grant 310030_138330) and by a Swiss Government Excellence Scholarship (awarded to A. Teijeira).

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Authors and Affiliations

  1. Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang-Pauli Str. 10, HCI H413, 8093, Zurich, Switzerland

    Alvaro Teijeira, Erica Russo & Cornelia Halin

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  1. Alvaro Teijeira
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  2. Erica Russo
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  3. Cornelia Halin
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Correspondence to Cornelia Halin.

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This article is a contribution to the special issue on New paradigms in leukocyte trafficking, lessons for therapeutics - Guest Editors: F. W. Luscinskas and B. A. Imhof

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Teijeira, A., Russo, E. & Halin, C. Taking the lymphatic route: dendritic cell migration to draining lymph nodes. Semin Immunopathol 36, 261–274 (2014). https://doi.org/10.1007/s00281-013-0410-8

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  • DOI: https://doi.org/10.1007/s00281-013-0410-8

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