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Evaluating primary intra-arterial chemotherapy versus intravenous plus intra-arterial chemotherapy for advanced intraocular retinoblastoma

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Abstract

Purpose

Although intra-arterial chemotherapy (IAC) is commonly used for treating intraocular retinoblastoma, it is not a systemic therapy. We aimed to investigate whether the addition of intravenous chemotherapy (IVC) before IAC administration had any effects (whether beneficial or adverse) on patient outcomes.

Methods

This multicenter retrospective cohort study included 213 patients with advanced intraocular retinoblastoma who received IVC plus IAC (n = 103) or IAC alone (n = 110) between April 2009 and January 2017. Eyes were grouped according to the International Intraocular Retinoblastoma Classification. Kaplan–Meier and Cox regression analyses were performed to compare survival outcomes between the two groups. Moreover, details regarding enucleation were recorded.

Results

The 3-year ocular survival rates were 62% in the IVC plus IAC group and 68% in the IAC group (hazard ratio (HR) 0.88, 95% confidence interval (CI) 0.55–1.43, P = 0.61). Moreover, the corresponding 3-year overall survival rates were 97% and 93%, respectively (HR 1.56, 95% CI 0.41–5.90, P = 0.51), while the 3-year event-free survival rates were 76% and 72%, respectively (HR 0.96, 95% CI 0.56–1.65, P = 0.89).

Conclusions

Within a 3-year follow-up period, IVC plus IAC produced no additional benefit over primary IAC for treating advanced intraocular retinoblastoma in terms of local tumor control and extending survival. Longer follow-up periods are required to assess long-term efficacy.

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Funding

The National Natural Science Foundation of China (81571664, 81871323, 81801665), the National Natural Science Foundation of Guangdong Province (2018B030311024), and the Scientific Research General Project of Guangzhou Science Technology and Innovation Commission (201707010328).

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Author notes

  1. Qiuying Chen and Bin Zhang have contributed equally to this work

Authors and Affiliations

  1. Department of Radiology, The First Affiliated Hospital, Jinan University, No. 613, Huangpu West Road, Tianhe District, Guangzhou, 510627, Guangdong, People’s Republic of China

    Qiuying Chen, Bin Zhang, Xiaokai Mo, Lu Zhang & Shuixing Zhang

  2. Graduate College, Jinan University, Guangzhou, Guangdong, People’s Republic of China

    Qiuying Chen, Bin Zhang, Lu Zhang & Shuixing Zhang

  3. Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People’s Republic of China

    Yuhao Dong

  4. Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children’s Medical Center, No. 9, Jinsui Road, Tianhe District, Guangzhou, 510627, Guangdong, People’s Republic of China

    Jiejun Xia & Jing Zhang

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  1. Qiuying Chen
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  2. Bin Zhang
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  3. Yuhao Dong
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  4. Xiaokai Mo
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  5. Lu Zhang
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  7. Jing Zhang
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  8. Shuixing Zhang
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Contributions

Literature search: YHD, XKM, and LZ; study design: QYC, BZ, and SXZ; data collection: XKM, YHD, and LZ; data analysis and interpretation: JJX, QYC, and YHD; manuscript editing: QYC and BZ; manuscript review: SXZ and JZ. All authors read and approved the final version of the manuscript.

Corresponding authors

Correspondence to Jing Zhang or Shuixing Zhang.

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The authors have declared no conflicts of interest.

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This retrospective study was approved by the institutional review board of the First Affiliated Hospital of Jinan University.

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Informed consent from patients was exempted due to the retrospective nature of this study.

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Chen, Q., Zhang, B., Dong, Y. et al. Evaluating primary intra-arterial chemotherapy versus intravenous plus intra-arterial chemotherapy for advanced intraocular retinoblastoma. Cancer Chemother Pharmacol 85, 723–730 (2020). https://doi.org/10.1007/s00280-020-04036-w

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  • DOI: https://doi.org/10.1007/s00280-020-04036-w

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