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Gastric cancer with para-aortic lymph node metastases: do not miss a chance of cure!

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Abstract

This letter to editor is a comment to the paper by Wang et al. entitled: “A phase II trial of Xeloda and oxaliplatin (XELOX) neo-adjuvant chemotherapy followed by surgery for advanced gastric cancer patients with para-aortic lymph node metastasis”. In a phase II trial, patients with primary gastric cancer and clinical involvement of para-aortic nodes (PAN) were treated by neo-adjuvant chemotherapy with capecitabine and oxaliplatin combination, and responders were then submitted to gastrectomy with D2 lymphadenectomy. The diagnostic and therapeutic approach adopted in this protocol is discussed, with special reference to the potential limits of computed tomography scan for the clinical diagnosis of PAN metastases (false positive results), and the opportunity to perform a D2 plus para-aortic lymphadenectomy, to further increase the chance of cure in patients with suspected PAN metastases.

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References

  1. Wang Y, Yu YY, Li W et al (2014) A phase II trial of Xeloda and oxaliplatin (XELOX) neo-adjuvant chemotherapy followed by surgery for advanced gastric cancer patients with para-aortic lymph node metastasis. Cancer Chemother Pharmacol [Epub ahead of print]

  2. Marrelli D, Mazzei MA, Pedrazzani C et al (2011) High accuracy of multislices computed tomography (MSCT) for para-aortic lymph node metastases from gastric cancer: a prospective single-center study. Ann Surg Oncol 18(8):2265–2272

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  3. Roviello F, Pedrazzani C, Marrelli D et al (2010) Super-extended (D3) lymphadenectomy in advanced gastric cancer. Eur J Surg Oncol 36(5):439–446

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  4. Tsuburaya A, Mizusawa J, Tanaka Y et al (2014) Neoadjuvant chemotherapy with S-1 and cisplatin followed by D2 gastrectomy with para-aortic lymph node dissection for gastric cancer with extensive lymph node metastasis. Br J Surg 101(6):653–660

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, Surgery and Neuroscience, Unit of Surgical Oncology, University of Siena, Siena, Italy

    Daniele Marrelli & Franco Roviello

  2. Department of Medicine, Surgery and Neuroscience, Unit of Radiology, University of Siena, Siena, Italy

    Maria Antonietta Mazzei

  3. Policlinico Le Scotte, Viale Bracci, 53100, Siena, Italy

    Daniele Marrelli

Authors
  1. Daniele Marrelli
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  2. Maria Antonietta Mazzei
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  3. Franco Roviello
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Correspondence to Daniele Marrelli.

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Marrelli, D., Mazzei, M.A. & Roviello, F. Gastric cancer with para-aortic lymph node metastases: do not miss a chance of cure!. Cancer Chemother Pharmacol 74, 433–434 (2014). https://doi.org/10.1007/s00280-014-2491-z

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  • DOI: https://doi.org/10.1007/s00280-014-2491-z

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