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Prolonged accumulation of high-dose methotrexate in a case with large liver cysts

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Abstract

Methotrexate (MTX) has been documented to accumulate in “third spaces’’ such as pleural effusions or ascitic fluids, resulting in delayed clearance and severe toxicity. We present a case of Burkitt lymphoma possessing large liver cysts, up to the size of 7 × 7 cm, wherein clearance of high-dose MTX was severely delayed, despite normal renal and liver functions. The serum MTX concentration was higher than 0.1 μM on day 12 and remained at toxic levels, higher than 0.01 μM, even on day 25, resulting in severe neutropenia, anorexia, and diarrhea. It was presumed that MTX accumulated in the liver cysts over time and was slowly released back into the serum, resulting into prolonged high serum MTX concentrations. High dose of MTX in patients with large liver cysts induces severe toxicity by virtue of MTX accumulation in the cysts and its subsequent delayed clearance.

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Fig. 1
Fig. 2

Abbreviations

MTX:

Methotrexate

CT:

Computed tomography

Ara-C:

Cytarabine

LV:

Leucovorin

BUN:

Blood urea nitrogen

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Authors and Affiliations

  1. Department of Hematology and Oncology, Nissay Hospital, 6-3-1 Itachibori, Nishi-ku, Osaka, Osaka, 550-0012, Japan

    Manabu Kawakami

  2. Department of Medicine, National Hospital Organization, Osaka Minami Medical Center, 2-1 Kido-Higashi-Machi, Kawachinagano, Osaka, 586-8521, Japan

    Manabu Kawakami, Hiroki Omori, Tamotsu Yamagami & Toshihiro Soma

  3. Department of Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamada-Oka, Suita, Osaka, 565-0871, Japan

    Hiroki Omori

Authors
  1. Manabu Kawakami
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  2. Hiroki Omori
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  3. Tamotsu Yamagami
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  4. Toshihiro Soma
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Correspondence to Manabu Kawakami.

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Kawakami, M., Omori, H., Yamagami, T. et al. Prolonged accumulation of high-dose methotrexate in a case with large liver cysts. Cancer Chemother Pharmacol 64, 619–622 (2009). https://doi.org/10.1007/s00280-009-0982-0

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  • DOI: https://doi.org/10.1007/s00280-009-0982-0

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