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Liquid biopsies of plasma and cerebrospinal fluid are useful for detection of intravascular lymphoma with central nervous system symptoms alone

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Acknowledgements

We thank the patients and clinical staff at Wakayama Medical University Hospital for their participation in this study.

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Authors and Affiliations

  1. Department of Hematology/Oncology, Wakayama Medical University, Kimiidera 811-1, Wakayama, 641-8510, Japan

    Hiroki Hosoi, Ikuro Tanigawa, Hideki Kosako, Takayuki Hiroi, Toshiki Mushino, Shogo Murata, Shinobu Tamura & Takashi Sonoki

  2. Department of Hematology, Fujita Health University, Toyoake, Japan

    Akinao Okamoto & Akihiro Tomita

  3. Department of Human Pathology, Wakayama Medical University, Wakayama, Japan

    Ryuta Iwamoto & Shin-Ichi Murata

  4. Department of Neurology, Wakayama Medical University, Wakayama, Japan

    Jinsoo Koh & Megumi Mori

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  1. Hiroki Hosoi
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  2. Ikuro Tanigawa
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  14. Takashi Sonoki
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Corresponding author

Correspondence to Hiroki Hosoi.

Ethics declarations

Ethics approval

This study was approved by the ethics committee of Wakayama Medical University (No. 2919). All procedures performed in studies involving human participants were carried out in accordance with the ethical standards of the relevant institutional and/or national research committees and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Consent for publication

Informed consent was obtained from the patient.

Conflict of interest

Akihiro Tomita received lecture fee from Chugai Pharmaceutical, Takeda Pharmaceutical, and research fund from Perseus Proteomics Inc, Novartis Phama K.K., Pfizer Japan Inc, Chugai Pharmaceutical, Kyowa Kirin, Ono Pharmaceutical, Taiho Pharmaceutical. The other authors declare that they have no conflicts of interest.

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Supplementary Information

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277_2021_4572_MOESM1_ESM.pdf

Supplementary file1 Supplementary Fig. 1 Magnetic resonance imaging (MRI) findings obtained with diffusion-weighted imaging (left; DWI) and T1-weighted imaging (right; T1WI). Acute ischemic stroke (arrow) and minor bleeding (arrowhead) were also seen. Supplementary Fig. 2 Microscopic features of the frontal lobe brain biopsy specimen. The number of atypical cells in the blood vessels were too small to allow a definitive diagnosis to be made. Hematoxylin-eosin staining, x40. Supplementary Fig. 3 MRI findings obtained before and after the first course of chemotherapy. The patient’s MRI findings improved after one cycle of combination chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone). FLAIR, T2-weighted fluid-attenuated inversion recovery; CE-MRI, contrast-enhanced MRI; CTx, chemotherapy. (PDF 24410 KB)

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Hosoi, H., Tanigawa, I., Kosako, H. et al. Liquid biopsies of plasma and cerebrospinal fluid are useful for detection of intravascular lymphoma with central nervous system symptoms alone. Ann Hematol 101, 709–711 (2022). https://doi.org/10.1007/s00277-021-04572-2

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  • DOI: https://doi.org/10.1007/s00277-021-04572-2

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