References
Geyer JT, Subramaniyam S, Jiang Y, Elemento O, Ferry JA, de Leval L, Nakashima MO, Liu YC, Martin P, Mathew S, Orazi A, Tam W (2015) Lymphoblastic transformation of follicular lymphoma: a clinicopathologic and molecular analysis of 7 patients. Hum Pathol 46:260–271
Kluin P, Harris NL, Stein H, Leoncini L, Campo E, Jaffe ES, Gascoyne RD, Swerdlow SH (2017) High grade B-cell lymphoma. In: WHO classification of tumours of hematopoietic and lymphoid tissue. WHO IARC Press, pp 335–341
Moench L, Sachs Z, Aasen G, Dolan M, Dayton V, Courville EL (2016) Double- and triple-hit lymphomas can present with features suggestive of immaturity, including TdT expression, and create diagnostic challenges. Leuk Lymphoma 57:2626–2635
Slot LM, Hoogeboom R, Smit LA, Wormhoudt TA, Biemond BJ, Oud ME, Schilder-Tol EJ, Mulder AB, Jongejan A, van Kampen AH, Kluin PM, Guikema JE, Bende RJ, van Noesel CJ (2016) B-Lymphoblastic lymphomas evolving from follicular lymphomas co-express surrogate light chains and mutated gamma heavy chains. Am J Pathol 186:3273–3284
Ok CY, Medeiros LJ, Thakral B, Tang G, Jain N, Jabbour E, Pierce SA, Konoplev S (2019) High-grade B-cell lymphomas with TdT expression: a diagnostic and classification dilemma. Mod Pathol 32(1):48–58
Mamessier E, Broussais-Guillaumot F, Chetaille B, Bouabdallah R, Xerri L, Jaffe ES, Nadel B (2014) Nature and importance of follicular lymphoma precursors. Haematologica 99:802–810
Merron B, Davies A (2018) Double hit lymphoma: how do we define it and how do we treat it? Best Pract Res Clin Haematol 31:233–240
Cohen JB (2018) Novel therapies for relapsed/refractory aggressive lymphomas. Hematol Am Soc Hematol Educ Program 30(1):75–82
Sha C, Barrans S, Cucco F, Bentley MA, Care MA, Cummin T, Kennedy H, Thompson JS, Uddin R, Worrillow L, Chalkley R, van Hoppe M, Ahmed S, Maishman T, Caddy J, Schuh A, Mamot C, Burton C, Tooze R, Davies A, Du MQ, Johnson PWM, Westhead DR (2018) Molecular high-grade B-cell lymphoma: defining a poor-risk group that requires different approaches to therapy. J Clin Oncol 37:1–11
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Ethical approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent
Informed consent was obtained from the patient included in the study.
Conflict of interest
The authors declare that they have no conflict of interest.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Electronic supplementary material
ESM 1
(PDF 339 kb)
Rights and permissions
About this article
Cite this article
Bravo-Perez, C., Pajares, I., Muiña, B. et al. Double hit B cell precursor leukemia/lymphoma in a patient with a prior diagnosis of follicular lymphoma: a diagnostic and therapeutic dilemma. Ann Hematol 98, 2837–2839 (2019). https://doi.org/10.1007/s00277-019-03829-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00277-019-03829-1