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High cut-off dialysis as a salvage therapy option in high-dose methotrexate chemotherapy?

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References

  1. Ackland SP, Schilsky RL (1987) High-dose methotrexate: a critical reappraisal. J Clin Oncol 5:2017–2031

    CAS  PubMed  Google Scholar 

  2. Smeland E, Fuskevag OM, Nymann K, Svendesn JS, Olsen R, Lindal S, Bremnes RM, Aarbakke J (1996) High-dose 7-hydromethotrexate: acute toxicity and lethality in a rat model. Cancer Chemother Pharacol 37:415–422

    Article  CAS  Google Scholar 

  3. Abelson HT, Fosburg MT, Beardsley GP, Goorin AM, Gorka C, Link M, Link D (1983) Methotrexate-induced renal impairment: clinical studies and rescue from systemic toxicity with high-dose leucovorin and thymidine. J Clin Oncol 1:208–216

    CAS  PubMed  Google Scholar 

  4. Widemann BC, Balis FM, Kempf-Bielack B, Bielack S, Pratt CB, Ferrari S, Bacci G, Craft AW, Adamson PC (2004) High-dose methotrexate-induced nephrotoxicity in patients with osteosarcoma. Cancer 100:2222–2232

    Article  CAS  PubMed  Google Scholar 

  5. Schwartz S, Borner K, Muller K, Martus P, Fischer L, Korfel A, Auton T, Thiel E (2007) Glucarpidase (carboxypeptidase g2) intervention in adult and elderly cancer patients with renal dysfunction and delayed methotrexate elimination after high-dose methotrexate therapy. Oncologist 12:1299–1308

    Article  CAS  PubMed  Google Scholar 

  6. Wall SM, Johansen MJ, Molony DA, DuBose TD Jr, Jaffe N, Madden T (1996) Effective clearance of methotrexate using high-flux hemodialysis membranes. Am J Kidney Dis 28:846–854

    Article  CAS  PubMed  Google Scholar 

  7. Schmidt JJ, Hafer C, Clajus C, Hadem J, Beutel G, Schmidt BM, Kielstein JT (2012) New high-cutoff dialyzer allows improved middle molecule clearance without an increase in albumin loss: a clinical crossover comparison in extended dialysis. Blood Purif 34:246–252

    Article  CAS  PubMed  Google Scholar 

  8. Thiel E, Korfel A, Martus P, Kanz L, Griesinger F, Rauch M, Roth A, Hertenstein B, von Toll T, Hundsberger T, Mergenthaler HG, Leithauser M, Birnbaum T, Fischer L, Jahnke K, Herrlinger U, Plasswilm L, Nagele T, Pietsch T, Bamberg M, Weller M (2010) High-dose methotrexate with or without whole brain radiotherapy for primary CNS lymphoma (G-PCNSL-SG-1): a phase 3, randomised, non-inferiority trial. Lancet Oncol 11:1036–1047

    Article  CAS  PubMed  Google Scholar 

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Conflict of interest

AB, PI, CH, KM, DP and AG declare that they have no conflict of interest. BMWS received honoraria for lectures by Fresenius Medical Care.

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Correspondence to Philipp Ivanyi.

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Ethical statement

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. Informed consent was obtained from all the patient.

Anna Bertram and Philipp Ivanyi contributed equally to this study.

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Bertram, A., Ivanyi, P., Hafer, C. et al. High cut-off dialysis as a salvage therapy option in high-dose methotrexate chemotherapy?. Ann Hematol 93, 1053–1055 (2014). https://doi.org/10.1007/s00277-013-1909-8

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  • DOI: https://doi.org/10.1007/s00277-013-1909-8

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