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High prevalence of hepatitis B and hepatitis C virus infections in Korean patients with hematopoietic malignancies

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Abstract

We performed a large case–control study (3,932 cases, 15,562 controls) to investigate the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) with hematopoietic malignancies in Korea, where HBV is endemic. HBV was present in 636 control patients (4.1%), 333 lymphoma patients (12.4%), and 75 leukemia patients (6.0%). HCV infection was present in 173 control patients (1.1%), 76 lymphoma patients (2.8%), and 18 leukemia patients (1.4%). Co-infection of HBV and HCV was present in one (0.007%) control patient, seven lymphoma patients (0.3%), and one leukemia patient (0.08%). HBV infection was associated with increased risks for most subtypes of B and T/NK-cell lymphomas, Hodgkin’s lymphoma, and acute myeloid leukemia. HCV infection was associated with increased risks for diffuse large B cell lymphoma, extranodal marginal zone B cell lymphoma, peripheral T cell lymphoma, and acute lymphoid leukemia B cell early pre-B type. HBV seems to have a more important role than HCV in the pathogenesis of specific hematologic malignancies in Korea.

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References

  1. Amin J, Dore GJ, O’Connell DL, Bartlett M, Tracey E, Kaldor JM, Law MG (2006) Cancer incidence in people with hepatitis B or C infection: a large community-based linkage study. J Hepatol 45:197–203

    Article  PubMed  Google Scholar 

  2. Anderson LA, Pfeiffer R, Warren JL, Landgren O, Gadalla S, Berndt SI, Ricker W, Parsons R, Wheeler W, Engels EA (2008) Hematopoietic malignancies associated with viral and alcoholic hepatitis. Cancer Epidemiol Biomark Prev 17:3069–3075

    Article  Google Scholar 

  3. Bianco E, Marcucci F, Mele A, Musto P, Cotichini R, Sanpaolo MG, Iannitto E, De Renzo A, Martino B, Specchia G, Montanaro M, Barbui AM, Nieddu R, Pagano L, Rapicetta M, Franceschi S, Mandelli F, Pulsoni A (2004) Prevalence of hepatitis C virus infection in lymphoproliferative diseases other than B-cell non-Hodgkin’s lymphoma, and in myeloproliferative diseases: an Italian Multi-Center case-control study. Haematologica 89:70–76

    PubMed  Google Scholar 

  4. Bosch FX, Ribes J, Cleries R, Diaz M (2005) Epidemiology of hepatocellular carcinoma. Clin Liver Dis 9:191–211, v

    Article  PubMed  Google Scholar 

  5. Chen MH, Hsiao LT, Chiou TJ, Liu JH, Gau JP, Teng HW, Wang WS, Chao TC, Yen CC, Chen PM (2008) High prevalence of occult hepatitis B virus infection in patients with B cell non-Hodgkin’s lymphoma. Ann Hematol 87:475–480

    Article  PubMed  Google Scholar 

  6. Dal Maso L, Franceschi S (2006) Hepatitis C virus and risk of lymphoma and other lymphoid neoplasms: a meta-analysis of epidemiologic studies. Cancer Epidemiol Biomark Prev 15:2078–2085

    Article  CAS  Google Scholar 

  7. Dal Maso L, Talamini R, Montella M, Crovatto M, Franceschi S (2004) Hepatitis B and C viruses and Hodgkin lymphoma: a case-control study from Northern and Southern Italy. Haematologica 89:e141–e142

    Google Scholar 

  8. Gentile G, Mele A, Monarco B, Vitale A, Pulsoni A, Visani G, Castelli G, Rapicetta M, Verani P, Martino P, Mandelli F (1996) Hepatitis B and C viruses, human T-cell lymphotropic virus types I and II, and leukemias: a case-control study. The Italian leukemia study group. Cancer Epidemiol Biomark Prev 5:227–230

    CAS  Google Scholar 

  9. Gisbert JP, Garcia-Buey L, Pajares JM, Moreno-Otero R (2003) Prevalence of hepatitis C virus infection in B-cell non-Hodgkin’s lymphoma: systematic review and meta-analysis. Gastroenterology 125:1723–1732

    Article  PubMed  Google Scholar 

  10. Jeong S, Yim HW, Bae SH, Lee WC (2008) Changes of Hepatitis B Surface Antigen Seroprevalence in Korea, 1998–2005. Korean J Epidemiol 30:119–127

    Article  Google Scholar 

  11. Kim JH, Bang YJ, Park BJ, Yoo T, Kim CW, Kim TY, Heo DS, Lee HS, Kim NK (2002) Hepatitis B virus infection and B-cell non-Hodgkin’s lymphoma in a hepatitis B endemic area: a case-control study. Jpn J Cancer Res 93:471–477

    CAS  PubMed  Google Scholar 

  12. Ko YH, Kim CW, Park CS, Jang HK, Lee SS, Kim SH, Ree HJ, Lee JD, Kim SW, Huh JR (1998) REAL classification of malignant lymphomas in the Republic of Korea: incidence of recently recognized entities and changes in clinicopathologic features. Hematolymphoreticular Study Group of the Korean Society of Pathologists. Revised European-American lymphoma. Cancer 83:806–812

    Article  CAS  PubMed  Google Scholar 

  13. Lim ST, Fei G, Quek R, Lim LC, Lee LH, Yap SP, Loong S, Tao M (2007) The relationship of hepatitis B virus infection and non-Hodgkin’s lymphoma and its impact on clinical characteristics and prognosis. Eur J Haematol 79:132–137

    Article  CAS  PubMed  Google Scholar 

  14. Marcucci F, Mele A, Spada E, Candido A, Bianco E, Pulsoni A, Chionne P, Madonna E, Cotichini R, Barbui A, De Renzo A, Dore F, Iannitto E, Liso V, Martino B, Montanaro M, Pagano L, Musto P, Rapicetta M (2006) High prevalence of hepatitis B virus infection in B-cell non-Hodgkin’s lymphoma. Haematologica 91:554–557

    PubMed  Google Scholar 

  15. Matsuo K, Kusano A, Sugumar A, Nakamura S, Tajima K, Mueller NE (2004) Effect of hepatitis C virus infection on the risk of non-Hodgkin’s lymphoma: a meta-analysis of epidemiological studies. Cancer Sci 95:745–752

    Article  CAS  PubMed  Google Scholar 

  16. Nath A, Agarwal R, Malhotra P, Varma S (2009) Prevalence of Hepatitis B virus infection in Non-Hodgkin's lymphoma. A systematic review and meta-analysis. Intern Med J (in press)

  17. Park SC, Jeong SH, Kim J, Han CJ, Kim YC, Choi KS, Cho JH, Lee M, Jung HH, Ki SS, Chang YH, Lee SS, Park YH, Lee KH (2008) High prevalence of hepatitis B virus infection in patients with B-cell non-Hodgkin’s lymphoma in Korea. J Med Virol 80:960–966

    Article  CAS  PubMed  Google Scholar 

  18. Sonmez M, Bektas O, Yilmaz M, Durmus A, Akdogan E, Topbas M, Erturk M, Ovali E, Omay SB (2007) The relation of lymphoma and hepatitis B virus/hepatitis C virus infections in the region of East Black Sea, Turkey. Tumori 93:536–539

    PubMed  Google Scholar 

  19. Squadrito G, Pollicino T, Cacciola I, Caccamo G, Villari D, La Masa T, Restuccia T, Cucinotta E, Scisca C, Magazzu D, Raimondo G (2006) Occult hepatitis B virus infection is associated with the development of hepatocellular carcinoma in chronic hepatitis C patients. Cancer 106:1326–1330

    Article  PubMed  Google Scholar 

  20. Sun CA, Farzadegan H, You SL, Lu SN, Wu MH, Wolfe L, Hardy W, Huang GT, Yang PM, Lee H, Chen CJ (1996) Mutual confounding and interactive effects between hepatitis C and hepatitis B viral infections in hepatocellular carcinogenesis: a population-based case-control study in Taiwan. Cancer Epidemiol Biomarkers Prev 5:173–178

    CAS  PubMed  Google Scholar 

  21. Agresti A (2002) Categorical Data Analysis, 2nd edn. Wiley, New Jersey

    Book  Google Scholar 

  22. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (2007) WHO classification of Tumours of Haematopoietic and Lymphoid tissue, 4th edn. International Agency for Research on Cancer (IARC), Lyon

    Google Scholar 

  23. Ulcickas Yood M, Quesenberry CP Jr, Guo D, Caldwell C, Wells K, Shan J, Sanders L, Skovron ML, Iloeje U, Manos MM (2007) Incidence of non-Hodgkin’s lymphoma among individuals with chronic hepatitis B virus infection. Hepatology 46:107–112

    Article  PubMed  Google Scholar 

  24. Wang F, Xu RH, Han B, Shi YX, Luo HY, Jiang WQ, Lin TY, Huang HQ, Xia ZJ, Guan ZZ (2007) High incidence of hepatitis B virus infection in B-cell subtype non-Hodgkin lymphoma compared with other cancers. Cancer 109:1360–1364

    Article  PubMed  Google Scholar 

  25. Yeo W, Johnson PJ (2006) Diagnosis, prevention and management of hepatitis B virus reactivation during anticancer therapy. Hepatology 43:209–220

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

We thank Seonok Kim for statistical analysis.

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Authors and Affiliations

  1. Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Poongnap-dong, Songpa-gu, Seoul, South Korea

    Jun Kang, Jeong Hyun Cho & Jooryung Huh

  2. Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

    Cheol Won Suh & Dae Ho Lee

  3. Department of Laboratory Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

    Heung Bum Oh, Yong Hak Sohn, Hyun Sook Chi, Chan Jeong Park & Sung Soo Jang

  4. Department of Hematology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

    Kyoo Hyung Lee, Je-Hwan Lee & Jung Hee Lee

  5. Department of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

    Sang Wook Lee

  6. Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

    Young Hwa Chung

  7. Department of Health Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

    Tae Hyup Kim

  8. Departments of Biostatistics and Epidemiology Cluster, IARC, Lyon, France

    Hai-Rim Shin

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  1. Jun Kang
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Correspondence to Jooryung Huh.

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Kang, J., Cho, J.H., Suh, C.W. et al. High prevalence of hepatitis B and hepatitis C virus infections in Korean patients with hematopoietic malignancies. Ann Hematol 90, 159–164 (2011). https://doi.org/10.1007/s00277-010-1055-5

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  • DOI: https://doi.org/10.1007/s00277-010-1055-5

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