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Mesenchymal stem cells for the treatment of refractory pure red cell aplasia after major ABO-incompatible hematopoietic stem cell transplantation

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Abstract

Pure red cell aplasia (PRCA) is a well-known, although infrequent, hematological complication after allogeneic hematopoietic stem cell transplantation (HSCT). PRCA occurs in cases of major ABO mismatch between donor and recipient and is believed to be due to inhibition of donor erythroid progenitors by residual host isohemagglutinins. The purpose of our study was to further evaluate the efficacy of human adipose tissue-derived mesenchymal stem cells (AMSC) as the salvage therapy for refractory PRCA after major ABO-incompatible HSCT. Two patients with refractory pure red cell aplasia received intravenous infusions of AMSC at a dose of 1.5 × 106/kg of the patients’ weight, and rapid recovery from PRCA without any side effects was observed. We conclude that AMSC seems to be a promising therapeutic option in patients with PRCA after ABO-mismatched HSCT, in whom conventional treatment fails.

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Acknowledgement

We want to thank the staff at the Center of Excellence in Tissue Engineering, Henan Tumor Hospital, Henan Institute of Haematology, Henan Medical School, Henan University, Zhengzhou, China. This study was supported by grants of National Development Plan of High Technology 863 (no. 2002AA205061) and Henan Outstanding Youth Foundation (no. 0612000900).

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Authors and Affiliations

  1. Henan Tumor Hospital, Henan Institute of Haematology, Henan Medical School, Henan University, 127 Dongming Road, Zhengzhou, 450008, China

    Baijun Fang, Yongping Song & Ning Li

  2. Institute of Haematology and Blood Diseases Hospital, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Baijun Fang, Jing Li, Qin Han & Robert Chunhua Zhao

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  1. Baijun Fang
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  2. Yongping Song
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  3. Ning Li
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  4. Jing Li
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  5. Qin Han
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  6. Robert Chunhua Zhao
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Correspondence to Yongping Song.

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Fang, B., Song, Y., Li, N. et al. Mesenchymal stem cells for the treatment of refractory pure red cell aplasia after major ABO-incompatible hematopoietic stem cell transplantation. Ann Hematol 88, 261–266 (2009). https://doi.org/10.1007/s00277-008-0599-0

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  • DOI: https://doi.org/10.1007/s00277-008-0599-0

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