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Neutrophil aggregates in a 13-year-old girl: a rare hematological phenomenon

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Abstract

Aggregation of neutrophils in peripheral blood smears is a very rare, mostly self-limiting phenomenon and may result in pseudoleukopenia. In the majority of cases, malignancies, infections, or hepatic disorders have been identified as the underlying condition. Although the exact reason for neutrophil aggregation in vitro has not been clarified, its relation to the use of ethylenediaminetetraacetate acid as an anticoagulant has been described in adults. We report here on the occurrence of transient neutrophil aggregation in a 13-year-old girl with Herpes simplex and concomitant Mycoplasma pneumoniae infection.

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Fig. 1. a, b

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References

  1. Bizzaro N (1993) Granulocyte aggregation is edetic acid and temperature dependent. Arch Pathol Lab Med 117:528–530

    CAS  PubMed  Google Scholar 

  2. Bizzaro N, Piazza I (1991) Lymphocytic clusters in peripheral blood: an atypical morphologic pattern of chronic lymphocytic leukemia. Acta Haematol 86:209–211

    CAS  PubMed  Google Scholar 

  3. Deol I, Hernandez AM, Pierre RV (1995) Ethylenediamine tetraacetic acid-associated leukoagglutination. Am J Clin Pathol 103:338–340

    CAS  PubMed  Google Scholar 

  4. Epstein HD, Kruskall MS (1988) Spurious leukopenia due to in vitro granulocyte aggregation. Am J Clin Pathol 89:652–655

    CAS  PubMed  Google Scholar 

  5. Galifi M, Schinella M, Nicoli M, Lippi G (1993) Instrumental reports and effect of anticoagulants in a case of neutrophil agglutination in vitro. Haematologica 78:364–370

    CAS  PubMed  Google Scholar 

  6. Guibaud S, Plumet-Leger A, Frobert Y (1983) Transient neutrophil aggregation in a patient with infectious mononucleosis. Am J Clin Pathol 80:883–884

    CAS  PubMed  Google Scholar 

  7. Hillyer CD, Knopf AN, Berkman EM (1990) EDTA-dependent leukoagglutination. Am J Clin Pathol 94:458–461

    CAS  PubMed  Google Scholar 

  8. Juneja S, Wolf M, McLennan R (1992) Clumping of lymphoma cells in peripheral blood induced by EDTA. J Clin Pathol 45:538–540

    CAS  PubMed  Google Scholar 

  9. Kobayashi S, Seki K, Yamaguchi M, Maruta A, Kodama F (1991) Studies on EDTA-dependent pseudoneutropenia. Rinsho Ketsueki 32:205–211

    CAS  PubMed  Google Scholar 

  10. Lesesve JF, Haristoy X, Thouvenin M, Latger-Cannard V, Buisine J, Lecompte T (2000) Pseudoleucopenia due to in vitro leukocyte agglutination polynuclear neutrophils: experience of a laboratory, review of the literature and future management. Ann Biol Clin (Paris) 58:417–424

    Google Scholar 

  11. Robbins SH, Conly MA, Oettinger J (1991) Cold-induced granulocyte agglutination. A cause of pseudoleukopenia. Arch Pathol Lab Med 115:155–157

    CAS  PubMed  Google Scholar 

  12. Rohr LR, Rivers FM (1990) Spurious automated leukopenia due to in vitro granulocyte aggregation. Am J Clin Pathol 93:572–574

    CAS  PubMed  Google Scholar 

  13. Savage RA (1989) Analytic inaccuracy resulting from hematology specimen characteristics. Three cases of clinically misleading artifacts affecting white blood cell and platelet counts. Am J Clin Pathol 92:295–299

    CAS  PubMed  Google Scholar 

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Acknowledgement

We thank Elke Harbst for expert technical assistance.

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Authors and Affiliations

  1. Department of Pediatrics, University of Kiel, Schwanenweg 20, 24105, Kiel, Germany

    A. Claviez & R. Santer

  2. Department of Medicine II, University of Kiel, Kiel, Germany

    H.-A. Horst

  3. Department of Pediatrics, University of Dresden, Dresden, Germany

    M. Suttorp

Authors
  1. A. Claviez
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  2. H.-A. Horst
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  3. R. Santer
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  4. M. Suttorp
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Correspondence to A. Claviez.

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Claviez, A., Horst, HA., Santer, R. et al. Neutrophil aggregates in a 13-year-old girl: a rare hematological phenomenon. Ann Hematol 82, 251–253 (2003). https://doi.org/10.1007/s00277-003-0627-z

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  • DOI: https://doi.org/10.1007/s00277-003-0627-z

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