Abstract
Objective
The objectives of this study were to recognize the endoscopic anatomy of the cavernous sinus and to understand the standard, purely endoscopic endonasal approaches to this anatomic structure. This basic information will facilitate our surgical procedures and decrease the rate of surgical complications.
Materials and methods
Seven fresh adult cadavers were studied bilaterally (n = 14). We used Karl Storz 0 and 30°, 4 mm, 18 cm and 30 cm rod lens rigid endoscope in our dissections. After cadaver preparation, extended endoscopic endonasal approaches were performed to access the cavernous sinus.
Results
In the seven cadavers, the cavernous sinus and superior orbital fissure, on both sides, were widely exposed with extended endoscopic endonasal approach. The antero-inferior portion of the cavernous sinus was exposed by removing the superior and the middle turbinates and the posterior ethmoidal cells (extended endoscopic endonasal transsphenoidal approach); the whole lateral wall of the cavernous sinus was exposed by removing the anterior and the posterior ethmoidal cells (endonasal ethmoido-pterygo-sphenoidal approach: far lateral); and the medial wall of the cavernous sinus was exposed by introducing the 30° endoscope from the contralateral nostril (contralateral endoscopic endonasal transsphenoidal approach). According to the neurovascular architecture, the lateral wall of the cavernous sinus is divided into the superior triangular area, the superior quadrangular area and the inferior quadrangular area. This division can facilitate understanding of the anatomic relations of the cavernous sinus from the endoscopic view.
Conclusion
Knowledge of the anatomy of the cavernous sinus obtained with an endoscopic view of cadaver dissections is an essential step in the learning curve of endoscopic skull base surgery, and is important for endoscopic treatment of various pathologies in this region. In this anatomic study, we reviewed the approaches to the cavernous sinus with an endoscopic view and identified the neurovascular relations. This approach will help in performing safer and minimally invasive surgery.
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References
Abuzayed B, Tanriover N, Gazioglu N et al (2009) Extended endoscopic endonasal approach to the pterygopalatine fossa: anatomic study. J Neurosurg Sci 53(2):37–44
Abuzayed B, Tanriover N, Gazioglu N et al (2009) Endoscopic endonasal approach to the orbital apex and medial orbital wall: anatomic study and clinical applications. J Craniofac Surg 20(5):1594–1600
Abuzayed B, Tanriover N, Gazioglu N et al (2010) Extended endoscopic endonasal approach to the clival region. J Craniofac Surg 21(1):245–251
Abuzayed B, Tanriover N, Gazioglu N et al (2010) Endoscopic anatomy of the oculomotor nerve: defining the blind spot during endoscopic skull base surgery. Childs Nerv Syst. doi:10.1007/s00381-009-1051-z (Epub ahead of print)
Abuzayed B, Tanriöver N, Ozlen F et al (2009) Endoscopic endonasal transsphenoidal approach to the sellar region: results of endoscopic dissection on 30 cadavers. Turk Neurosurg 19(3):237–244
Alfieri A, Jho HD (1987) Endoscopic endonasal approaches to the cavernous sinus: surgical approaches. Neurosurgery 49:354–362
Alfieri A, Jho HD (2001) Endoscopic endonasal cavernous sinus surgery: an anatomic study. Neurosurgery 48:827–837
Cappabianca P, Alfieri A, de Divitiis E (1998) Endoscopic endonasal transsphenoidal approach to the sella: towards functional endoscopic pituitary surgery (FEPS). Minim Invasive Neurosurg 41:66–73
Cavallo L, Cappabianca P, Galzio R et al (2005) Endoscopic transnasal approach to the cavernous sinus versus transcranial route: anatomic study. Neurosurgery 56(ONS Suppl 2):379–389
Couldwell WT, Sabit I, Weiss MH et al (1997) Transmaxillary approach to the anterior cavernous sinus: a microanatomic study. Neurosurgery 40:1307–1311
Das K, Spencer W, Nwagwu CI et al (2001) Approaches to the sellar and parasellar region: anatomic comparison of endonasal transsphenoidal, sublabial-transsphenoidal, and transethmoidal approaches. Neurol Res 23:51–54
de Divitiis E, Cappabianca P (2002) Endoscopic endonasal transsphenoidal surgery. In: Pickard JD (ed) Advances and technical standards in neurosurgery. Springer-Verlag, New York, pp 137–177
de Divitiis E, Cappabianca P (2003) Endoscopic endonasal transsphenoidal surgery. Springer-Verlag, New York
de Divitiis E, Cappabianca P, Cavallo LM (2002) Endoscopic transsphenoidal approach: adaptability of the procedure to different sellar lesions. Neurosurgery 51:699–707
Dietemann JL, Kehrli P, Maillot C et al (1998) Is there a dural wall between the cavernous sinus and the pituitary fossa? Anatomical and MRI findings. Neuroradiology 40:627–630
Dolenc VV (1983) Direct microsurgical repair of intracavernous vascular lesions. J Neurosurg 58:824–831
Dolenc VV (1989) Anatomy and surgery of the cavernous sinus. Springer-Verlag, Wien
Dolenc VV, Rogers L (2003) Microsurgical anatomy and surgery of the central skull base. Springer-Verlag, Wein, pp 43–46
Frank G, Pasquini E (2006) Endoscopic endonasal cavernous sinus surgery, with special reference to pituitary adenomas. Front Horm Res 34:64–82
Frank G, Pasquini E (2003) Approach to the cavernous sinus. In: de Divitiis E, Cappabianca P (eds) Endoscopic endonasal transsphenoidal surgery. Springer-Verlag, New York, pp 159–175
Frank G, Pasquini E, Calbucci F (2001) Endoscopic approach to the cavernous sinus via an ethmoido-pterygo-sphenoidal route. Presented at the 5th European Skull Base Society Congress, Copenhagen, Denmark
Fahlbusch R, Buchfelder M (1988) Transsphenoidal surgery of parasellar pituitary adenomas. Acta Neurochir (Wien) 92:93–99
Hashimoto N, Kikuchi H (1990) Transsphenoidal approach to infrasellar tumors involving the cavernous sinus. J Neurosurg 73:513–517
Inoue T, Rhoton AL Jr, Theele D et al (1990) Surgical approaches to the cavernous sinus: a microsurgical study. Neurosurgery 26:903–932
Jho HD (2000) Endoscopic transsphenoidal surgery. In: Schmidek HH (ed) Schmidek and Sweet operative neurosurgical techniques: indications, methods and results. W.B. Saunders Co., Philadelphia, pp 385–397
Jho HD, Ha HG (2004) Endoscopic endonasal skull base surgery: part 2, the cavernous sinus. Minim Invasive Neurosurg 47:9–15
Kassam AB, Prevedello DM, Carrau RL et al (2009) The front door to meckel’s cave: an anteromedial corridor via expanded endoscopic endonasal approach- technical considerations and clinical series. Neurosurgery 64(3 Suppl):71–82
Kawase T, van Loveren HR, Keller JT et al (1996) Meningeal architecture of the cavernous sinus: clinical and surgical implications. Neurosurgery 39:527–536
Kehrli P, Ali M, Reis M Jr et al (1998) Anatomy and embryology of the lateral sellar compartment (cavernous sinus) medial wall. Neurol Res 20:585–592
Kitano M, Taneda M (2001) Extended transsphenoidal approach with submucosal posterior ethmoidectomy for parasellar tumors: technical note. J Neurosurg 94:999–1004
Lee HY, Kim HU, Kim SS et al (2002) Surgical anatomy of the sphenopalatine artery in lateral nasal wall. Laryngoscope 112:1813–1818
Parkinson D (1965) A surgical approach to the cavernous portion of the carotid artery: anatomical studies and case report. J Neurosurg 43:474–483
Rhoton AL Jr, Hardy DG, Chambers SM (1979) Microsurgical anatomy and dissection of the sphenoid bone, cavernous sinus and sellar region. Surg Neurol 12:63–104
Rhoton AL Jr, Harris FS, Renn WH (1977) Microsurgical anatomy of the sellar region and cavernous sinus. In: Keener EB (ed) Clinical neurosurgery. Williams & Wilkins, Baltimore, pp 54–85
Sabit I, Schaefer SD, Couldwell WT (2000) Extradural extranasal combined transmaxillary transsphenoidal approach to the cavernous sinus: a minimally invasive microsurgical model. Laryngoscope 110:286–291
Taptas JN (1982) The so-called cavernous sinus: a review of the controversy and its implications for neurosurgeons. Neurosurgery 11:712–717
Umansky F, Nathan H (1982) The lateral wall of the cavernous sinus, with special reference to the nerves related to it. J Neurosurg 56:228–234
van Loveren HR, Keller JT, el-Kalliny M et al (1991) The Dolenc technique for cavernous sinus exploration (cadaveric prosection): technical note. J Neurosurg 74:837–844
Yasuda A, Campero A, Martins C et al (2004) The medial wall of the cavernous sinus: microsurgical anatomy. Neurosurgery 55:179–190
Yokoyama S, Hirano H, Moroki K et al (2001) Are nonfunctioning pituitary adenomas extending into the cavernous sinus aggressive and/or invasive? Neurosurgery 49:857–863
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Abuzayed, B., Tanriover, N., Gazioglu, N. et al. Endoscopic anatomy and approaches of the cavernous sinus: cadaver study. Surg Radiol Anat 32, 499–508 (2010). https://doi.org/10.1007/s00276-010-0651-3
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DOI: https://doi.org/10.1007/s00276-010-0651-3