Skip to main content
Log in

Percutaneous Treatment of Giant Cystic Echinococcosis in Liver: Catheterization Technique in Patients with CE1 and CE3a

  • Clinical Investigation
  • Non-Vascular Interventions
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

Purpose

This study aimed to evaluate the efficacy, safety, and follow-up results of the percutaneous treatment of cystic echinococcosis (CE) patients with giant hepatic cysts (at least one diameter > 10 cm).

Methods

Between January 2013 and 2018, 31 CE patients with 34 giant cysts classified as CE1 or CE3a (Gharbi type 1 or 2) according to the World Health Organization criteria and treated with the catheterization technique were analyzed retrospectively.

Results

Thirty-four giant hepatic cysts were treated using the catheterization technique. Technical success was 100%. One procedure was sufficient for 27 of these cysts, while six patients underwent a second procedure due to recurrence, recollection or complications; one did not accept a repeat procedure and decided to refer to surgery due to pain. Ten (29%) major complications developed. The overall clinical success was 97%. The mean follow-up period was 20 months (5–61 months), and the total reduction in the cyst volume was 92%.

Conclusion

The catheterization technique is effective in treating giant CE with acceptable complication rates.

Level of Evidence

Level 4, Clinical Investigation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Ustunsoz B, Ugurel MS, Uzar AI, Duru NK. Percutaneous treatment of hepatic hydatid cyst in pregnancy: long-term results. Arch Gynecol Obstet. 2008;277:547–50.

    Article  PubMed  Google Scholar 

  2. Brunetti E, Kern P, Vuitton DA. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop. 2010;114:1–16.

    Article  PubMed  Google Scholar 

  3. Khuroo MS, Wani NA, Javid G, Khan BA, Yattoo GN, Shah AH, et al. Percutaneous drainage compared with surgery for hepatic hydatid cysts. N Engl J Med. 1997;337:881–7.

    Article  CAS  PubMed  Google Scholar 

  4. Macpherson CNL, Vuitton DA, Gharbi HA, Caremani M, Frider B, Brunettii E, et al. International classification of ultrasound images in cystic echinococcosis for application in clinical and field epidemiological settings. Acta Trop. 2003;85:253–61.

    Article  Google Scholar 

  5. Men S, Yücesoy C, Edgüer TR, Hekimoǧlu B. Percutaneous treatment of giant abdominal hydatid cysts: long-term results. Surg Endosc Other Interv Tech. 2006;20:1600–6.

    Article  CAS  Google Scholar 

  6. Akhan O, Dincer A, GÖkÖz A, Sayek IS, Havlioglu S, Abbasoḡlu O, Eryilmaz M, Besim AY, Baris IZ. Percutaneous treatment of abdominal hydatid cysts with hypertonic saline and alcohol: an experimental study in sheep. Invest Radiol. 1993;28(2):121–7.

    Article  CAS  PubMed  Google Scholar 

  7. Akhan O, Ozmen MN, Dinçer A, Sayek I, Göçmen A. Liver hydatid disease: long-term results of percutaneous treatment. Radiology. 1996;198:259–64.

    Article  CAS  PubMed  Google Scholar 

  8. Men S, Cuneyt Y, Arda IS, Baran I. Percutaneous treatment of hepatic hydatid cysts: an alternative to surgery. Am J Roentgenol. 1999;172:83–9.

    Article  CAS  Google Scholar 

  9. Kahriman G, Ozcan N, Dogan S, Karaborklu O. Percutaneous treatment of liver hydatid cysts in 190 patients: a retrospective study. Acta Radiol. 2017;58:676–84.

    Article  PubMed  Google Scholar 

  10. Akhan O, Salik AE, Ciftci T, Akinci D, Islim F, Akpinar B. Comparison of long-term results of percutaneous treatment techniques for hepatic cystic echinococcosis types 2 and 3b. Am J Roentgenol. 2017;208:878–84.

    Article  Google Scholar 

  11. Akhan O, Gumus B, Akinci D, Karcaaltincaba M, Ozmen M. Diagnosis and percutaneous treatment of soft-tissue hydatid cysts. Cardiovasc Intervent Radiol. 2007;30:419–25.

    Article  PubMed  Google Scholar 

  12. Kern P, da Silva Menezes A, Akhan O, Müllhaupt B, Vizcaychipi KA, Budke C, et al. The echinococcoses: diagnosis, clinical management and burden of disease. Adv Parasitol. 2017;96:259–361.

    Article  CAS  PubMed  Google Scholar 

  13. Akhan O, Yildiz AE, Akinci D, Yildiz BD, Ciftci T. Is the adjuvant albendazole treatment really needed with PAIR in the management of liver hydatid cysts? a prospective, randomized trial with short-term follow-up results. Cardiovasc Intervent Radiol. 2014;37:1568–74.

    Article  PubMed  Google Scholar 

  14. Lucey BC, Kuligowska E. Radiologic management of cysts in the abdomen and pelvis. Am J Roentgenol. 2006;186:562–73.

    Article  Google Scholar 

  15. Paananen I, Hellström P, Leinonen S, Merikanto J, Perälä J, Päivänsalo M, et al. Treatment of renal cysts with single-session percutaneous drainage and ethanol sclerotherapy: long-term outcome. Urology. 2001;57:30–3.

    Article  CAS  PubMed  Google Scholar 

  16. Khuroo MS, Dar MY, Yattoo GN, Zargar SA, Javaid G, Khan BA, et al. Percutaneous drainage versus albendazole therapy in hepatic hydatidosis: a prospective, randomized study. Gastroenterology. 1993;104:1452–9.

    Article  CAS  PubMed  Google Scholar 

  17. Kapan S, Turhan AN, Kalayci MU, Alis H, Aygun E. Albendazole is not effective for primary treatment of hepatic hydatid cysts. J Gastrointest Surg. 2008;12:867–71.

    Article  PubMed  Google Scholar 

  18. Yagci G, Ustunsoz B, Kaymakcioglu N, Bozlar U, Gorgulu S, Simsek A, et al. Results of surgical, laparoscopic, and percutaneous treatment for hydatid disease of the liver: 10 years experience with 355 patients. World J Surg. 2005;29:1670–9.

    Article  PubMed  Google Scholar 

  19. Chautems R, Buhler L, Gold B, Chilcott M, Morel P, Mentha G. Long term results after complete or incomplete surgical resection of liver hydatid disease. Swiss Med Wkly. 2003;133:258–62.

    PubMed  Google Scholar 

  20. Sielaff TD, Taylor B, Langer B. Recurrence of hydatid disease. World J Surg. 2001;25:83–6.

    Article  CAS  PubMed  Google Scholar 

  21. Balik A, Başoğlu M, Çelebi F, Ören D, Polat KY, Atamanalp SS, Akçay MN. Surgical treatment of hydatid disease of the liver: review of 304 cases. Arch Surg. 1999;134(2):166–9.

    Article  CAS  PubMed  Google Scholar 

  22. Gavara CG, López-Andújar R, Ibáñez TB, Ángel JMR, Herraiz ÁM, Castellanos FO, et al. Review of the treatment of liver hydatid cysts. World J Gastroenterol: WJG. 2015;21:124.

    Article  Google Scholar 

  23. Zaharie F, Bartos D, Mocan L, Zaharie R, Iancu C, Tomus C. Open or laparoscopic treatment for hydatid disease of the liver? A 10-year single-institution experience. Surg Endosc. 2013;27:2110–6.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Perdomo R, Alvarez C, Monti J, Ferreira C, Chiesa A, Carbó A, et al. Principles of the surgical approach in human liver cystic echinococcosis. Acta Trop. 1997;64:109–22.

    Article  CAS  PubMed  Google Scholar 

  25. Schipper HG, Laméris JS, Van Delden OM, Rauws EA, Kager PA. Percutaneous evacuation (PEVAC) of multivesicular echinococcal cysts with or without cystobiliary fistulas which contain non-drainable material: first results of a modified PAIR method. Gut. 2002;50:718–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Ustunsoz B, Akhan O, Somuncu I. Percutaneous treatment of hydatid cysts of the liver: long-term results. Am J Roentgenol. 1999;172:91–6.

    Article  CAS  Google Scholar 

  27. Saylam B, Coşkun F, Demiriz B, Vural V, Çomçali B, Tez M. A new and simple score for predicting cystobiliary fistula in patients with hepatic hydatid cysts. Surg (United States). 2013;153:699–704.

    Google Scholar 

  28. Unalp HR, Baydar B, Kamer E, Yilmaz Y, Issever H, Tarcan E. Asymptomatic occult cysto-biliary communication without bile into cavity of the liver hydatid cyst: a pitfall in conservative surgery. Int J Surg. Elsevier Ltd. 2009;7:387–91.

    Google Scholar 

  29. Bosanac ZB, Lisanin L. Percutaneous drainage of hydatid cyst in the liver as a primary treatment: review of 52 consecutive cases with long-term follow-up. Clin Radiol. 2000;55:839–48.

    Article  CAS  PubMed  Google Scholar 

  30. Saremi F, McNamara TO. Hydatid cysts of the liver: long-term results of percutaneous treatment using a cutting instrument. AJR Am J Roentgenol. 1995;165:1163–7.

    Article  CAS  PubMed  Google Scholar 

  31. Canyigit M, Gumus M, Cay N, Erol B, Karaoglanoglu M, Akhan O. Refractory cystobiliary fistula secondary to percutaneous treatment of hydatid cyst: treatment with N-butyl 2-cyanoacrylate embolization. Cardiovasc Intervent Radiol. 2011;34:266–70.

    Article  Google Scholar 

  32. Akhan O, Ozmen MN. Percutaneous treatment of liver hydatid cysts. Eur J Radiol. 1999;32:76–85.

    Article  CAS  PubMed  Google Scholar 

  33. Giorgio A, Di Sarno A, De Stefano G, Liorre G, Farella N, Scognamiglio U, et al. Sonography and clinical outcome of viable hydatid liver cysts treated with double percutaneous aspiration and ethanol injection as first-line therapy: efficacy and long-term follow-up. Am J Roentgenol. 2009;193:186–92.

    Article  Google Scholar 

  34. Ozacmak ID, Ekiz F, Ozmen V, Isik A. Management of residual cavity after partial cystectomy for hepatic hydatidosis: comparison of omentoplasty with external drainage. Eur J Surg. 2000;166:696–9.

    Article  CAS  PubMed  Google Scholar 

  35. Harris KM, Morris DL, Tudor R, Toghill P, Hardcastle JD. Clinical and radiographic features of simple and hydatid cysts of the liver. Br J Surg. 1986;73:835–8.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Omur Balli.

Ethics declarations

Conflict of interest

None.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional ethics committee.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Balli, O., Balli, G., Cakir, V. et al. Percutaneous Treatment of Giant Cystic Echinococcosis in Liver: Catheterization Technique in Patients with CE1 and CE3a. Cardiovasc Intervent Radiol 42, 1153–1159 (2019). https://doi.org/10.1007/s00270-019-02248-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00270-019-02248-z

Keywords

Navigation