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Sequential and Simultaneous 4-Antenna Microwave Ablation in an Ex Vivo Bovine Liver Model

  • Laboratory Investigation
  • Non-Vascular Interventions
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Abstract

Aims

To determine the sizes and shapes of ablation zones in 4-antenna microwave ablation in ex vivo bovine liver model under different conditions of power delivery patterns, antenna spacings, and ablation durations, for further using of multi-antenna MWA strategies in the treatment of large hepatocellular carcinoma.

Methods

We tested protocols of eight ablations each on ex vivo bovine livers, involving simultaneous or sequential activation of four microwave antennas, spaced either 3 cm, 4 cm, or 5 cm apart, for either 10 or 15 min, at 60-W power. We determined the diameters, shapes, and temperatures of the ablation zones.

Results

Compared to sequential power delivery, simultaneous power delivery resulted in significantly larger ablation zone diameters (P < .001). The temperatures in ablation zones were significantly higher for simultaneous than for sequential power delivery. The largest ablation diameter (7.45 ± 0.06 cm) resulted from simultaneous delivery for 15 min using 4-cm antenna spacing.

Conclusions

Simultaneous 4-antenna microwave ablation results in larger ablation zones than sequential ablation, and 4-cm antenna spacing with a 15-minute ablation duration creates the largest ablation zone. This information may provide multi-antenna MWA strategies for large HCC in the further clinical practice.

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Acknowledgements

We would like to thank Ms. Xin Zheng for providing support and encouragement to Dr. Tianqi Zhang on his scientific research work.

Funding

This work was supported by National Natural Science Foundation of China (No. 81771955), Guangzhou Science and Technology Program, key projects of collaborative innovation of health medicine (No. 201704020228), and Guangzhou Science and Technology Program, key projects of collaborative innovation of production, learning and research (No. 201704020134), Sun Yat-sen University Clinical Trial 5010 Project (No. 2016002).

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Author notes

  1. Tian-qi Zhang and Sen-miao Huang contributed equally to this work and are considered co-first authors.

Authors and Affiliations

  1. Department of Minimally Invasive Interventional Radiology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, 510060, People’s Republic of China

    Tian-qi Zhang, Yang-kui Gu, Zhi-mei Huang, Han-xia Deng & Jin-hua Huang

  2. Department of Oncology, Panyu Central Hospital, 8 Fuyu East Road, Guangzhou, 511400, People’s Republic of China

    Sen-miao Huang

  3. Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, People’s Republic of China

    Xiong-ying Jiang

Authors
  1. Tian-qi Zhang
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  5. Zhi-mei Huang
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Contributions

Tian-Qi Zhang and Sen-Miao Huang participated equally in experiments and analyzed the data; Zhi-Mei Huang and Han-Xia Deng finished the statistical analysis; Tian-Qi Zhang finished the manuscript drafting; Yang-Kui Gu and Xiong-Ying Jiang gave the critical revision of the manuscript for important intellectual content; Jin-Hua Huang designed and coordinated the research.

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Correspondence to Jin-hua Huang.

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Cite this article

Zhang, Tq., Huang, Sm., Gu, Yk. et al. Sequential and Simultaneous 4-Antenna Microwave Ablation in an Ex Vivo Bovine Liver Model. Cardiovasc Intervent Radiol 42, 1466–1474 (2019). https://doi.org/10.1007/s00270-019-02241-6

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  • DOI: https://doi.org/10.1007/s00270-019-02241-6

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