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Superabsorbent Polymer Microspheres Prepared with Hypertonic Saline to Reduce Microsphere Expansion

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CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

Purpose

To analyze size changes of superabsorbent polymer (SAP) microspheres with the reduced expansion technique, and to evaluate pharmacological advantages of transarterial chemoembolization using cisplatin-loaded SAP microspheres with the reduced expansion technique.

Materials and Methods

In an in vitro study, diluted contrast materials containing different concentrations of sodium ions were examined to expand SAP microspheres and determined the reduced expansion technique. Size distributions of cisplatin-loaded SAP microspheres were analyzed. In an in vivo study, TACE was performed using cisplatin-loaded SAP microspheres with the reduced expansion and control techniques in 18 VX2 rabbits.

Results

The degree of expansion was reduced to the greatest extent by using a mixture of non-ionic contrast material and 10% NaCl at a 4:1 ratio. The mean diameter of the reduced expansion of cisplatin-loaded SAP microspheres was 188.4 μm, while that of the control expansion was 404.9 μm. The plasma platinum concentrations of the reduced expansion group at 5 min after TACE were significantly higher than those of the control expansion group (2.19 ± 0.77 vs. 0.75 ± 0.08 μg/mL, P = .01). The tumor platinum concentrations of the reduced expansion group at 1 h were significantly higher than those of the control expansion group (10.76 ± 2.57 vs. 1.57 ± 0.14 μg/g, P = .044).

Conclusion

The expanding level of SAP microspheres can be reduced by using hypertonic saline. Cisplatin-loaded SAP microspheres with the reduced expansion technique have the advantages of achieving higher cisplatin tissue concentration in TACE for liver tumors.

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Acknowledgements

We thank Ms. Marian Pahud for advice in submitting this article. The Funding was provided by Nippon Kayaku Co., Ltd.

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Authors and Affiliations

  1. Department of Radiology, Nara Medical University, 840 Shijo-cho, Kashihara, 634-8522, Japan

    Takeshi Sato, Toshihiro Tanaka, Hideyuki Nishiofuku, Yasushi Fukuoka, Tetsuya Masada, Shota Tatsumoto, Nagaaki Marugami & Kimihiko Kichikawa

  2. Department of Diagnostic Pathology, Nara Medical University, Kashihara, Japan

    Kohei Morita & Chiho Obayashi

  3. Gate Tower Institute for Image Guided Therapy, Izumisano, Osaka, Japan

    Shinich Hori

  4. Nippon Kayaku Co., Ltd., Tokyo, Japan

    Masaaki Kaneko & Ai Kijima

Authors
  1. Takeshi Sato
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  2. Toshihiro Tanaka
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  3. Hideyuki Nishiofuku
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  4. Yasushi Fukuoka
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  10. Shinich Hori
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  11. Masaaki Kaneko
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  12. Ai Kijima
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  13. Kimihiko Kichikawa
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Corresponding author

Correspondence to Toshihiro Tanaka.

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Conflict of interest

Nippon Kayaku Co., Ltd. supported this study. TT received research grant to conduct this study from Nippon Kayaku Co. MK and AK are employees of Nippon Kayaku Co., Ltd. SH is a trainer of Merit Medical and Nippon Kayaku Co., Ltd. The other authors have no conflicts of interest and financial disclosures to declare.

Ethical Approval

All applicable institutional and national guidelines for the care and use of animals were followed.

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Sato, T., Tanaka, T., Nishiofuku, H. et al. Superabsorbent Polymer Microspheres Prepared with Hypertonic Saline to Reduce Microsphere Expansion. Cardiovasc Intervent Radiol 41, 1412–1418 (2018). https://doi.org/10.1007/s00270-018-1990-4

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  • DOI: https://doi.org/10.1007/s00270-018-1990-4

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