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Safety Considerations and Local Tumor Control Following Percutaneous Image-Guided Cryoablation of T1b Renal Tumors

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Abstract

Objective

To retrospectively assess the safety and oncological efficacy of percutaneous image-guided cryoablation (CA) of T1b (> 4 cm/< 7 cm) renal tumors.

Materials and Methods

Institutional electronic records were retrospectively reviewed to identify the patients who had undergone percutaneous CA of T1b renal tumors between 2008 and 2016. CA was proposed by a multidisciplinary tumor board for cases with poor renal function or a single kidney; unsuitable for surgical resection; or genetic syndromes predisposing to multiple hereditary renal tumors.

Patients’ demographics, procedural and follow-up data were accurately collected and analyzed.

Results

Twenty-seven consecutive patients (12 females, 15 males; mean age 72.3 ± 14.3 years) were included. Mean tumor diameter was 47.9 ± 6.3 mm. MRI guidance was used in 6/27 cases (22.2%) and CT guidance in the remaining 21/27 (77.8%) cases. Hydro- and/or carbo-dissections were necessary in 21/27 cases (77.8%). Complications graded ≥ II were reported in three (11.1%) patients. Technical success and technical efficacy were 100 and 87.5%, respectively. Local tumor control (LTC) evaluated at imaging follow-up ≥ 6 months was 82.6, 72.3 and 60.3% at 12-, 24- and 36-month follow-up, respectively. One patient passed away 3 months after CA due to the metastatic evolution of the primary kidney cancer.

Conclusion

Percutaneous CA of T1b renal tumors is safe and satisfactory rates of LTC are expected at the early follow-ups. Further studies are needed to confirm the long-term efficacy of this procedure.

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Authors and Affiliations

  1. Department of Interventional Radiology, Nouvel Hôpital Civil (Hôpitaux Universitaires de Strasbourg), 1 Place de l’Hôpital, 67000, Strasbourg, France

    Sonia Hebbadj, Roberto Luigi Cazzato, Julien Garnon, Georgia Tsoumakidou & Afshin Gangi

  2. Department of Interventional Radiology, Royal Devon and Exeter Hospital NHS Trust, Barrack Rd, Exeter, EX2 5DW, UK

    Benham Shaygi

  3. Department of Interventional Radiology, Institut Bergonié, 229 cours de l’Argonne, 33000, Bordeaux, France

    Xavier Buy

  4. Department of Urology, Nouvel Hôpital Civil (Hôpitaux Universitaires de Strasbourg), 1 Place de l’Hôpital, 67000, Strasbourg, France

    Herve Lang

Authors
  1. Sonia Hebbadj
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  2. Roberto Luigi Cazzato
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  3. Julien Garnon
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  4. Benham Shaygi
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  5. Xavier Buy
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  6. Georgia Tsoumakidou
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  7. Herve Lang
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  8. Afshin Gangi
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Correspondence to Sonia Hebbadj.

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All authors have no conflicts of interest to disclose.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Hebbadj, S., Cazzato, R.L., Garnon, J. et al. Safety Considerations and Local Tumor Control Following Percutaneous Image-Guided Cryoablation of T1b Renal Tumors. Cardiovasc Intervent Radiol 41, 449–458 (2018). https://doi.org/10.1007/s00270-017-1820-0

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  • DOI: https://doi.org/10.1007/s00270-017-1820-0

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