Abstract
Purpose
Transarterial chemoembolization (TACE) is used to treat unresectable bone and soft tissue sarcoma (STS) and as a pre-surgical adjuvant treatment. However, its efficiency for advanced STS is undetermined. This study evaluated TACE’s efficiency in treating advanced STS and prognostic factors for patient survival.
Materials and Methods
We enrolled 39 patients with unresectable STS who underwent TACE as an alternative treatment during 2010–2014, with overall survival (OS) as the primary end point. Cancer pain was evaluated by visual analogue scores (VAS) before and after TACE procedures. Factors that affect survival were evaluated by multivariate analyses (Cox proportional hazard model).
Results
Mean OS after TACE was 23.7 ± 2.1 months, with 1-year OS 71.5 %, 2-year OS 45.8 %, and 3-year OS 32.5 %. Lesion number and tumor stage were key predictors of survival. TACE was found to decrease cancer pain VAS and increase relapse interval. Size of polyvinyl alcohol (PVA) particle diameter (P = 0.03) and imaging response (P = 0.044) were also found to affect relapse interval.
Conclusion
TACE was an effective treatment for advanced STS, with a 32.5 % 3-year OS rate, and led to lower cancer pain VAS and longer relapse intervals than chemoinfusion only. Smaller PVA particles are preferable during the TACE procedure.
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Acknowledgments
This work was partly funded by Key Disciplines Group Construction Project of Pudong Health Bureau of Shanghai (No. PWZxq2014-07), funding of Science and Technology Commission of Shanghai Municipality (No. 12ZR1422700) and Shen-Kang Hospital Development Center Project of Shanghai (No. SHDC12014902), and this work was also supported by National Natural Science Fundation of China (No. 81271683).
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We declare that we have no financial and personal relationships with people or organizations that can inappropriately influence our work; there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitled.
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Chunyu Jiang and Yonggang Wang have contributed equally to this work.
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Jiang, C., Wang, J., Wang, Y. et al. Treatment Outcome Following Transarterial Chemoembolization in Advanced Bone and Soft Tissue Sarcomas. Cardiovasc Intervent Radiol 39, 1420–1428 (2016). https://doi.org/10.1007/s00270-016-1399-x
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DOI: https://doi.org/10.1007/s00270-016-1399-x