Abstract
We herein present a patient undergoing selective internal radiation therapy with an almost normal lung shunt fraction of 11.5 %, developing histologically proven radiation pneumonitis. Due to a predominance of pulmonary consolidations in the right lower lung and its proximity to a large liver metastases located in the dome of the right liver lobe a Monte Carlo simulation was performed to estimate the effect of direct irradiation of the lung parenchyma. According to our calculations direct irradiation seems negligible and RP is almost exclusively due to ectopic draining of radioactive spheres.
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This research received no specific Grant from any funding agency in the public, commercial, or not-for-profit sectors.
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Tomas Dobrocky, Markus Fürstner, Bernd Klaeser, Ruben Lopez-Benitez, Yara Banz Wälti, and Levent Kara declare that they have no conflicts of interest.
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Dobrocky, T., Fuerstner, M., Klaeser, B. et al. Regional Radiation Pneumonitis After SIRT of a Subcapsular Liver Metastasis: What is the Effect of Direct Beta Irradiation?. Cardiovasc Intervent Radiol 38, 1025–1030 (2015). https://doi.org/10.1007/s00270-014-1015-x
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DOI: https://doi.org/10.1007/s00270-014-1015-x