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Percutaneous Radiofrequency Ablation of Lung Cancer Presenting as Ground-Glass Opacity

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Abstract

Purpose

We retrospectively evaluated the outcomes of lung cancer patients presenting with ground-glass opacity (GGO) who received radiofrequency ablation (RFA).

Methods

Sixteen patients (5 men and 11 women; mean age, 72.6 years) with 17 lung cancer lesions showing GGO (mean long axis diameter, 1.6 cm) underwent a total of 20 percutaneous computed tomography (CT) fluoroscopy-guided RFA sessions, including three repeated sessions for local progression. Lung cancer with GGO was defined as a histologically confirmed malignant pulmonary lesion with a GGO component accounting for >50 % of the lesion on high-resolution CT. Procedure outcomes were evaluated.

Results

There were no major complications. Pneumothorax occurred in 15 of 20 treatment sessions: 14 were asymptomatic, and 1 required chest tube placement but resolved satisfactorily within 48 h. Minor pulmonary hemorrhage occurred in two and mild pneumonitis in one. The median tumor follow-up period was 61.5 (range 6.1–96.6) months. The effectiveness rates of the primary and secondary techniques were 100 and 100 % at 1 year, 93.3 and 100 % at 2 years, and 78.3 and 92.3 % at 3 years, respectively. The median patient follow-up period was 65.6 (range 6.1–96.6) months. One patient died owing to recurrent other cancer 11.7 months after RFA, whereas the other 15 remained alive. Overall survival and disease-specific survival rates were 93.3 and 100 % at 1 year and 93.3 and 100 % at 5 years, respectively.

Conclusions

RFA for lung cancer with GGO was safe and effective, and resulted in promising survival rates.

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References

  1. Godoy MC, Naidich DP (2009) Subsolid pulmonary nodules and the spectrum of peripheral adenocarcinomas of the lung: recommended interim guidelines for assessment and management. Radiology 253(3):606–622 PMID: 19952025

    Article  PubMed  Google Scholar 

  2. Hiraki T, Sakurai J, Tsuda T et al (2006) Risk factors for local progression after percutaneous radiofrequency ablation of lung tumors: evaluation based on a preliminary review of 342 tumors. Cancer 107(12):2873–2880 PMID: 17096433

    Article  PubMed  Google Scholar 

  3. Okuma T, Matsuoka T, Yamamoto A et al (2010) Determinants of local progression after computed tomography-guided percutaneous radiofrequency ablation for unresectable lung tumors: 9-year experience in a single institution. Cardiovasc Intervent Radiol 33(4):787–793 PMID: 19967367

    Article  PubMed  Google Scholar 

  4. de Baère T, Palussière J, Aupérin A et al (2006) Midterm local efficacy and survival after radiofrequency ablation of lung tumors with minimum follow-up of 1 year: prospective evaluation. Radiology 240(2):587–596 PMID: 16864679

    Article  PubMed  Google Scholar 

  5. Lencioni R, Crocetti L, Cioni R et al (2008) Response to radiofrequency ablation of pulmonary tumours: a prospective, intention-to-treat, multicentre clinical trial (the RAPTURE study). Lancet Oncol 9(7):621–628 PMID: 18565793

    Article  PubMed  Google Scholar 

  6. Kim TJ, Lee JH, Lee CT et al (2008) Diagnostic accuracy of CT-guided core biopsy of ground-glass opacity pulmonary lesions. AJR Am J Roentgenol 190(1):234–239 PMID: 18094317

    Article  PubMed  Google Scholar 

  7. Hur J, Lee HJ, Nam JE et al (2009) Diagnostic accuracy of CT fluoroscopy-guided needle aspiration biopsy of ground-glass opacity pulmonary lesions. AJR Am J Roentgenol 192(3):629–634 PMID: 19234257

    Article  PubMed  Google Scholar 

  8. Hiraki T, Gobara H, Mimura H et al (2011) Percutaneous radiofrequency ablation of clinical stage I non-small cell lung cancer. J Thorac Cardiovasc Surg 142(1):24–30 PMID: 21529847

  9. Hiraki T, Gobara H, Mimura H et al (2011) Radiofrequency ablation of lung cancer at Okayama University Hospital: a review of 10 years of experience. Acta Med Okayama 65(5):287–297 PMID: 22037265

  10. Yamamoto A, Nakamura K, Matsuoka T et al (2005) Radiofrequency ablation in a porcine lung model: correlation between CT and histopathologic findings. AJR Am J Roentgenol 185(5):1299–1306 PMID: 16247153

    Article  PubMed  Google Scholar 

  11. Abtin FG, Eradat J, Gutierrez AJ, Lee C, Fishbein MC, Suh RD (2012) Radiofrequency ablation of lung tumors: imaging features of the postablation zone. Radiographics 32(4):947–969 PMID: 22786987

    Article  PubMed Central  PubMed  Google Scholar 

  12. Hiraki T, Gobara H, Mimura H et al (2010) Does tumor type affect local control by radiofrequency ablation in the lungs? Eur J Radiol 74(1):136–141 PMID: 19231125

    Article  PubMed  Google Scholar 

  13. Goldberg SN, Grassi CJ, Cardella JF et al (2009) Image-guided tumor ablation: standardization of terminology and reporting criteria. J Vasc Interv Radiol 20(7 Suppl):S377–S390 PMID: 19560026

    Article  PubMed  Google Scholar 

  14. Noguchi M, Morikawa A, Kawasaki M et al (1995) Small adenocarcinoma of the lung. Histologic characteristics and prognosis. Cancer 75(12):2844–2852 PMID: 7773933

    Article  CAS  PubMed  Google Scholar 

  15. Kondo T, Yamada K, Noda K, Nakayama H, Kameda Y (2002) Radiologic-prognostic correlation in patients with small pulmonary adenocarcinomas. Lung Cancer 36(1):49–57 PMID: 11891033

    Article  PubMed  Google Scholar 

  16. Asamura H, Suzuki K, Watanabe S, Matsuno Y, Maeshima A, Tsuchiya R (2003) A clinicopathological study of resected subcentimeter lung cancers: a favorable prognosis for ground glass opacity lesions. Ann Thorac Surg 76(4):1016–1022 PMID: 14529977

    Article  PubMed  Google Scholar 

  17. Nakao M, Yoshida J, Goto K et al (2012) Long-term outcomes of 50 cases of limited-resection trial for pulmonary ground-glass opacity nodules. J Thorac Oncol 7(10):1563–1566 PMID: 22878750

    Article  PubMed  Google Scholar 

  18. Hamamoto Y, Kataoka M, Yamashita M et al (2012) Factors affecting the local control of stereotactic body radiotherapy for lung tumors including primary lung cancer and metastatic lung tumors. Jpn J Radiol 30(5):430–434 PMID: 22450903

    Article  PubMed  Google Scholar 

  19. Simon CJ, Dupuy DE, DiPetrillo TA et al (2007) Pulmonary radiofrequency ablation: long-term safety and efficacy in 153 patients. Radiology 243(1):268–275 PMID: 17392258

    Article  PubMed  Google Scholar 

  20. Ambrogi MC, Fanucchi O, Cioni R et al (2011) Long-term results of radiofrequency ablation treatment of stage I non-small cell lung cancer: a prospective intention-to-treat study. J Thorac Oncol 6(12):2044–2051 PMID: 22052222

    Article  PubMed  Google Scholar 

  21. Yasui K, Kanazawa S, Sano Y et al (2004) Thoracic tumors treated with CT-guided radiofrequency ablation: initial experience. Radiology 231(3):850–857 PMID: 15105453

    Article  PubMed  Google Scholar 

  22. Anderson EM, Lees WR, Gillams AR (2009) Early indicators of treatment success after percutaneous radiofrequency of pulmonary tumors. Cardiovasc Intervent Radiol 32(3):478–483 PMID: 19127381

    Article  PubMed  Google Scholar 

  23. Kim YS, Lee WJ, Rhim H, Lim HK, Choi D, Lee JY (2010) The minimal ablative margin of radiofrequency ablation of hepatocellular carcinoma (>2 and <5 cm) needed to prevent local tumor progression: 3D quantitative assessment using CT image fusion. AJR Am J Roentgenol 195(3):758–765 PMID: 20729457

    Article  PubMed  Google Scholar 

  24. Kim KW, Lee JM, Klotz E et al (2011) Safety margin assessment after radiofrequency ablation of the liver using registration of preprocedure and postprocedure CT images. AJR Am J Roentgenol 196(5):W565–W572 PMID: 21512046

    Article  PubMed  Google Scholar 

  25. Hasegawa M, Sone S, Takashima S et al (2000) Growth rate of small lung cancers detected on mass CT screening. Br J Radiol 73(876):1252–1259 PMID: 11205667

    Article  CAS  PubMed  Google Scholar 

  26. Kim TJ, Park CM, Goo JM, Lee KW (2012) Is there a role for FDG PET in the management of lung cancer manifesting predominantly as ground-glass opacity? AJR Am J Roentgenol 198(1):83–88 PMID: 22194482

    Article  PubMed  Google Scholar 

  27. Kashima M, Yamakado K, Takaki H et al (2011) Complications after 1000 lung radiofrequency ablation sessions in 420 patients: a single center’s experiences. AJR Am J Roentgenol 197(4):W576–W580 PMID: 21940529

    Article  PubMed  Google Scholar 

  28. Hiraki T, Mimura H, Gobara H et al (2008) Repeat radiofrequency ablation for local progression of lung tumors: does it have a role in local tumor control? J Vasc Interv Radiol 19(5):706–711 PMID: 18440459

    Article  PubMed  Google Scholar 

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Conflict of interest

Toshihiro Iguchi, Takao Hiraki, Hideo Gobara, Hiroyasu Fujiwara, Yusuke Matsui, Junichi Soh, Shinichi Toyooka, Katsuyuki Kiura, and Susumu Kanazawa have no conflicts of interest to declare.

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Authors and Affiliations

  1. Department of Radiology, Okayama University Medical School, 2-5-1 Shikata-cho kita-ku, Okayama, 700-8558, Japan

    Toshihiro Iguchi, Takao Hiraki, Hideo Gobara, Hiroyasu Fujiwara, Yusuke Matsui & Susumu Kanazawa

  2. Department of General Thoracic Surgery, Okayama University Medical School, 2-5-1 Shikata-cho kita-ku, Okayama, 700-8558, Japan

    Junichi Soh & Shinichi Toyooka

  3. Department of Clinical Genomic Medicine, Okayama University Medical School, 2-5-1 Shikata-cho kita-ku, Okayama, 700-8558, Japan

    Shinichi Toyooka

  4. Department of Respiratory Medicine, Okayama University Medical School, 2-5-1 Shikata-cho kita-ku, Okayama, 700-8558, Japan

    Katsuyuki Kiura

Authors
  1. Toshihiro Iguchi
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  2. Takao Hiraki
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  3. Hideo Gobara
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  4. Hiroyasu Fujiwara
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  5. Yusuke Matsui
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  6. Junichi Soh
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  7. Shinichi Toyooka
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  8. Katsuyuki Kiura
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  9. Susumu Kanazawa
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Correspondence to Toshihiro Iguchi.

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Iguchi, T., Hiraki, T., Gobara, H. et al. Percutaneous Radiofrequency Ablation of Lung Cancer Presenting as Ground-Glass Opacity. Cardiovasc Intervent Radiol 38, 409–415 (2015). https://doi.org/10.1007/s00270-014-0926-x

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  • DOI: https://doi.org/10.1007/s00270-014-0926-x

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