Skip to main content
Log in

Acute Pancreatitis after Percutaneous Mechanical Thrombectomy: Case Report and Review of the Literature

  • Case Report
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

Purpose

We describe a case of severe acute pancreatitis after percutaneous mechanical thrombectomy (PMT) and review the literature for the occurrence of this complication.

Materials and Methods

A 53-year-old man with a history of bilateral external iliac artery stent placement sought care for acute onset of lifestyle-limiting left claudication. Angiography confirmed left external iliac stent occlusion, and PMT with the AngioJet Xpeedior catheter (Possis Medical, Minneapolis MN) was performed.

Results

After PMT of the occluded external iliac artery, a residual in-stent stenosis required the placement of a second iliac stent. The procedure was complicated by severe acute pancreatitis. Other causes of pancreatitis were eliminated during the patient’s hospital stay. A literature review revealed nine cases of acute pancreatitis after PMT.

Conclusion

Although rare, pancreatitis can be a devastating complication of PMT. The development of pancreatitis seems to be related to the products of extensive hemolysis triggering an inflammatory process. To prevent this complication, we recommend that close attention be paid to the duration and extent of PMT, thereby avoiding extensive hemolysis and subsequent complications.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Allie DE, Hebert CJ, Lirtzman MD et al (2004) Novel simultaneous combination chemical thrombolysis/rheolytic thrombectomy therapy for acute critical limb ischemia: the power-pulse spray technique. Catheter Cardiovasc Interv 63:512–522

    Article  PubMed  Google Scholar 

  2. Lin PH, Zhou W, Dardik A et al (2006) Catheter-direct thrombolysis versus pharmcomechanical thrombectomy for treatment of symptomatic lower extremity deep venous thrombosis. Am J Surg 192:782–788

    Article  PubMed  Google Scholar 

  3. Margheri M, Vittori G, Vecchio S et al (2008) Early and long-term clinical results of angiojet rheolytic thrombectomy in patients with acute pulmonary embolism. Am J Cardiol 101:252–258

    Article  PubMed  Google Scholar 

  4. Kim HS, Patra A, Khan J et al (2005) Transhepatic catheter-directed thrombectomy and thrombolysis of acute superior mesenteric venous thrombosis. J Vasc Interv Radiol 16:1685–1691

    PubMed  Google Scholar 

  5. Vesely TM, Williams D, Weiss M et al (1999) Comparison of the angiojet rheolytic catheter to surgical thrombectomy for the treatment of thrombosed hemodialysis grafts. J Vasc Interv Radiol 10:1195–1205

    Article  CAS  PubMed  Google Scholar 

  6. Kasirajan K, Gray B, Beavers FP et al (2001) Rheolytic thrombectomy in the management of acute and subacute limb-threatening ischemia. J Vasc Interv Radiol 12:413–421

    Article  CAS  PubMed  Google Scholar 

  7. Mair DC, Eastlund T, Rosen G et al (2005) Hemolysis during percutaneous mechanical thrombectomy can mimic a hemolytic transfusion reaction. Transfusion 45:1291–1294

    Article  CAS  PubMed  Google Scholar 

  8. Ansel GM, George BS, Botti CF et al (2002) Rheolytic thrombectomy in the management of limb ischemia: 30-day results from a multicenter registry. J Endovasc Ther 9:395–402

    Article  PubMed  Google Scholar 

  9. Dwarka D, Schwartz SA, Smyth SH et al (2006) Bradyarrhythmias during use of the angiojet system. J Vasc Interv Radiol 17:1693–1695

    Article  PubMed  Google Scholar 

  10. Fontaine AB, Borsa JJ, Hoffer EK et al (2001) Type III heart block with peripheral use of the angiojet thrombectomy system. J Vasc Interv Radiol 12:1223–1225

    Article  CAS  PubMed  Google Scholar 

  11. Danetz JS, McLafferty RB, Ayerdi J et al (2004) Pancreatitis caused by rheolytic thrombolysis: an unexpected complication. J Vasc Interv Radiol 15:857–860

    PubMed  Google Scholar 

  12. Lebow M, Cassada D, Grandas O et al (2007) Acute pancreatitis as a complication of percutaneous mechanical thrombectomy. J Vasc Surg 46:366–368

    Article  PubMed  Google Scholar 

  13. Piercy KT, Ayerdi J, Geary RL et al (2006) Acute pancreatitis: a complication associated with rheolytic mechanical thrombectomy of deep venous thrombosis. J Vasc Surg 44:1110–1113

    Article  PubMed  Google Scholar 

  14. Walker JF, Cronin CJ, Donohoe JF et al (1981) Acute severe intravascular haemolysis: an unrecognized cause of pancreatitis. BMJ (Clin Res Ed) 13:1929

    Article  Google Scholar 

  15. Sweet SJ, McCarthy S, Steingart R et al (1996) Hemolytic reactions mechanically induced by kinked hemodialysis lines. Am J Kidney Dis 27:262–266

    Article  CAS  PubMed  Google Scholar 

  16. Bruno MJ, van Westerloo DJ, van Dorp WT et al (2000) Acute pancreatitis in peritoneal dialysis and haemodialysis: risk, clinical course, outcome and possible aetiology. Gut 46:385–389

    Article  CAS  PubMed  Google Scholar 

  17. Saruç M, Ozden N, Yuceyar H et al (2002) How hemolysis causes acute pancreatitis. Med Sci Monit 8:51–52

    Google Scholar 

  18. Druml W, Laggner AN, Lenz K et al (1991) Pancreatitis in acute hemolysis. Ann Hematol 63:39–41

    Article  CAS  PubMed  Google Scholar 

  19. Saruç M, Yuceyar H, Turkel N et al (2003) An experimental model of hemolysis induced acute pancreatitis. Braz J Med Biol Res 36:879–886

    PubMed  Google Scholar 

  20. Thrower E, Husain S, Gorelick F (2008) Molecular basic for pancreatitis. Curr Opin Gastroenterol 24:580–585

    Article  PubMed  Google Scholar 

  21. Graça-Souza AV, Arruda MA, de Freitas MS et al (2002) Neutrophil activation by heme: implications for inflammatory processes. Blood 99:4160–4165

    Article  PubMed  Google Scholar 

  22. Lyoumi S, Puy H, Tamion F et al (1999) Heme and acute inflammation: role in vivo of heme in the hepatic expression of positive acute-phase reactants in rats. Eur J Biochem 261:190–196

    Article  CAS  PubMed  Google Scholar 

  23. Wagener FADTG, Eggert A, Boerman OC et al (2001) Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase. Blood 98:1802–1811

    Article  CAS  PubMed  Google Scholar 

  24. Nagy E, Eaton JW, Jeney V et al (2010) Red cells, hemoglobin, heme, iron, and atherogenesis. Arterioscler Thromb Vasc Biol 30:1347–1353

    Article  CAS  PubMed  Google Scholar 

  25. Becker R, Meyer zu Vilsendorf A, Terbish T et al (2007) Induction of heme oxygenase-1 improves the survival of pancreas grafts by prevention of pancreatitis after transplantation. Transplantation 84:1644–1655

    Article  CAS  PubMed  Google Scholar 

  26. Saruç M, Yuceyar H, Turkel N et al (2007) The role of heme in hemolysis-induced acute pancreatitis. Med Sci Monit 13(3):BR67–BR72

    PubMed  Google Scholar 

  27. Abhati M, Uzan M, Souid M (2007) Hemolysis-induced acute pancreatitis secondary to kinked hemodialysis blood lines. Hemodial Int 11:38–41

    Article  Google Scholar 

  28. Rambausek M, Wallmeier K, Schwarzbeck A, Ritz E (1995) Abdominal emergency in a dialysis patient: haemolysis from kinking of dialysis tubing. Nephrol Dial Transplant 10:2141–2143

    CAS  PubMed  Google Scholar 

  29. Walker JF, Cronin CJ, Donohoe JF et al (1981) Acute severe intravascular haemolysis: an unrecognized cause of pancreatitis. Br Med J (Clin Res Ed) 282:1929

    Article  CAS  Google Scholar 

Download references

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Richard C. Hershberger.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hershberger, R.C., Bornak, A., Aulivola, B. et al. Acute Pancreatitis after Percutaneous Mechanical Thrombectomy: Case Report and Review of the Literature. Cardiovasc Intervent Radiol 34 (Suppl 2), 25–30 (2011). https://doi.org/10.1007/s00270-010-0027-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00270-010-0027-4

Keywords

Navigation