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Acute Effects of Liver Vein Occlusion by Stent-Graft Placed in Transjugular Intrahepatic Portosystemic Shunt Channel: An Experimental Study

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Abstract

The purpose of this study was to evaluate the effects of hepatic vein occlusion by stent-graft used in transjugular intrahepatic portosystemic shunt (TIPS). The experiments were performed in six healthy pigs under general anesthesia. Following percutaneous transhepatic implantation of a port-a-cath in the right hepatic vein, TIPS was created with a stent-graft (Viatorr; W L Gore, Flagstaff, AZ, USA). The outflow from the hepatic vein, blocked by the stent-graft was documented by injection of contrast medium and repeated injections of 99Tcm-labeled human serum albumin through the port-a-cath. After 2 weeks, the outflow was re-evaluated, the pigs were sacrificed, and histopathologic examination of the liver was performed. Occlusion of the hepatic vein by a stent-graft had a short and temporary effect on the outflow. Histopathological examination from the affected liver segment showed no divergent pattern. Stent-grafts used in TIPS block the outflow from the liver vein, but do not have a prolonged circulatory effect and do not affect the liver parenchyma.

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Authors and Affiliations

  1. Department of Radiology, University Hospital, Lund, Sweden

    Inger Keussen

  2. Department of Radiation Physics, University Hospital, Lund, Sweden

    Lennart Bergqvist

  3. Department of Pathology, University Hospital, Lund, Sweden

    Pehr Rissler

  4. Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA

    Wojciech Cwikiel

Authors
  1. Inger Keussen
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  2. Lennart Bergqvist
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  3. Pehr Rissler
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  4. Wojciech Cwikiel
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Correspondence to Inger Keussen.

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Keussen, I., Bergqvist, L., Rissler, P. et al. Acute Effects of Liver Vein Occlusion by Stent-Graft Placed in Transjugular Intrahepatic Portosystemic Shunt Channel: An Experimental Study. Cardiovasc Intervent Radiol 29, 120–123 (2006). https://doi.org/10.1007/s00270-004-0288-x

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  • DOI: https://doi.org/10.1007/s00270-004-0288-x

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