Skip to main content

Advertisement

Log in

Autologous Fat Grafting for Primary Breast Augmentation: A Systematic Review

  • Review
  • Published:
Aesthetic Plastic Surgery Aims and scope Submit manuscript

Abstract

As the technique of autologous fat grafting is being refined and perfected, its clinical applications are expanding. The use of autologous fat grafting for primary breast augmentation is controversial due to a lack of clarity regarding its safety and efficacy. Most notably, concerns about interference with the detection of breast cancer have been raised, but these have not been clearly addressed in the literature. To help surgeons gain further insight, the authors conducted a systematic review of the literature, carefully comparing technique, clinical outcome, radiologic impact, and complications in all available data on this subject. Although an optimal method of autologous fat grafting for primary breast augmentation is yet to be standardized, further strong evidence-based studies are necessary to confirm the findings of this approach.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. ASPRS Ad-Hoc Committee on New Procedures (1987) Report on autologous fat transplantation. Plast Surg Nurs 7:140–141

    Google Scholar 

  2. Gutowski KA (2009) Current applications and safety of autologous fat grafts: a report of the ASPS Fat Graft Task Force. Plast Reconstr Surg 124:272–280

    Article  PubMed  CAS  Google Scholar 

  3. Manabe Y, Toda S, Miyazaki K, Sugihara H (2003) Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer–stromal cell interactions. J Patholol 201:221–228

    Article  Google Scholar 

  4. Yu JM, Jun ES, Bae YC, Jung JS (2008) Mesenchymal stem cells derived from human adipose tissues favor tumor cell growth in vivo. Stem Cells Dev 17:463–473

    Article  PubMed  CAS  Google Scholar 

  5. Muehlberg FL, Song YH, Krohn A et al (2009) Tissue-resident stem cells promote breast cancer growth and metastasis. Carcinogenesis 30:589–597

    Article  PubMed  CAS  Google Scholar 

  6. Iyengar P, Combs TP, Shah SJ et al (2003) Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene 22:6408–6423

    Article  PubMed  CAS  Google Scholar 

  7. Carvajal J, Patino JH (2008) Mammographic findings after breast augmentation with autologous fat injection. Aesthet Surg J 28:153–162

    Article  PubMed  CAS  Google Scholar 

  8. Bone RC, Balk RA, Cerra FB et al (2009) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee, American College of Chest Physicians/Society of Critical Care Medicine, 1992. Chest 136(5 Suppl):e28

  9. Neuber F (1893) Fat transplantation. Chir Kongr Verhandl Dsch Gesellch Chir 20:66

    Google Scholar 

  10. Czerny V (1895) Plastischer ersatz der brustdruse durch ein lipoma. Chir Kongr Verhandl 2:216

    Google Scholar 

  11. Peer L (1950) Loss of weight and volume in human fat grafts: With postulation of a “cell survival theory”. Plast Reconstr Surg 5:217

    Article  Google Scholar 

  12. Ellenbogen R (1986) Free autogenous pearl fat grafts in the face: a preliminary report of a rediscovered technique. Ann Plast Surg 16:179–194

    Article  PubMed  CAS  Google Scholar 

  13. Bircoll M (1987) Cosmetic breast augmentation utilizing autologous fat and liposuction techniques. Plast Reconstr Surg 79:267–271

    Article  PubMed  CAS  Google Scholar 

  14. Bircoll M, Novack BH (1987) Autologous fat transplantation employing liposuction techniques. Ann Plast Surg 18:327–329

    Article  PubMed  CAS  Google Scholar 

  15. Eremia S, Newman N (2000) Long-term follow-up after autologous fat grafting: analysis of results from 116 patients followed at least 12 months after receiving the last of a minimum of two treatments. Dermatol Surg 26:1150–1158

    Article  PubMed  CAS  Google Scholar 

  16. Hyakusoku H, Ogawa R, Ono S, Ishii N, Hirakawa K (2009) Complications after autologous fat injection to the breast. Plast Reconstr Surg 123:360–370 discussion 371–362

    Article  PubMed  CAS  Google Scholar 

  17. Kwak JY, Lee SH, Park HL, Kim JY, Kim SE, Kim EK (2004) Sonographic findings in complications of cosmetic breast augmentation with autologous fat obtained by liposuction. J Clin Ultrasound 32:299–301

    Article  PubMed  Google Scholar 

  18. Maillard GF (1994) Liponecrotic cysts after augmentation mammaplasty with fat injections. Aesthetic Plast Surg 18:405–406

    Article  PubMed  CAS  Google Scholar 

  19. Mu DL, Luan J, Mu L, Xin MQ (2009) Breast augmentation by autologous fat injection grafting: management and clinical analysis of complications. Ann Plast Surg 63:124–127

    Article  PubMed  CAS  Google Scholar 

  20. Pulagam SR, Poulton T, Mamounas EP (2006) Long-term clinical and radiologic results with autologous fat transplantation for breast augmentation: case reports and review of the literature. Breast J 12:63–65

    Article  PubMed  Google Scholar 

  21. Talbot SG, Parrett BM, Yaremchuk MJ (2010) Sepsis after autologous fat grafting. Plast Reconstr Surg 126:162e–164e

    Article  PubMed  Google Scholar 

  22. Valdatta L, Thione A, Buoro M, Tuinder S (2001) A case of life-threatening sepsis after breast augmentation by fat injection. Aesthetic Plast Surg 25:347–349

    Article  PubMed  CAS  Google Scholar 

  23. Zheng DN, Li QF, Lei H et al (2008) Autologous fat grafting to the breast for cosmetic enhancement: experience in 66 patients with long-term follow-up. J Plast Reconstr Aesthet Surg 61:792–798

    Article  PubMed  Google Scholar 

  24. Pierrefeu-Lagrange AC, Delay E, Guerin N, Chekaroua K, Delaporte T (2006) Radiological evaluation of breasts reconstructed with lipomodeling. Ann Chir Plast Esthet 51:18–28

    Article  PubMed  CAS  Google Scholar 

  25. Coleman SR, Saboeiro AP (2007) Fat grafting to the breast revisited: safety and efficacy. Plast Reconstr Surg 119:775–785 discussion 786–777

    Article  PubMed  CAS  Google Scholar 

  26. Chala LF, de Barros N, de Camargo Moraes P et al (2004) Fat necrosis of the breast: mammographic, sonographic, computed tomography, and magnetic resonance imaging findings. Curr Probl Diagn Radiol 33:106–126

    Article  PubMed  Google Scholar 

  27. Mizuno H, Hyakusoku H (2010) Fat grafting to the breast and adipose-derived stem cells: Recent scientific consensus and controversy. Aesthet Surg J 30:381–387

    Google Scholar 

  28. Yoshimura K, Sato K, Aoi N, Kurita M, Hirohi T, Harii K (2008) Cell-assisted lipotransfer for cosmetic breast augmentation: supportive use of adipose-derived stem/stromal cells. Aesthetic Plast Surg 32:48–55 discussion 56–47

    Article  PubMed  Google Scholar 

  29. Yoshimura K, Sato K, Aoi N et al (2008) Cell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells. Dermatol Surg 34:1178–1185

    Article  PubMed  CAS  Google Scholar 

  30. Minn KW, Min KH, Chang H, Kim S, Heo EJ (2010) Effects of fat preparation methods on the viabilities of autologous fat grafts. Aesthetic Plast Surg 34:626–631

    Article  PubMed  Google Scholar 

  31. Sun B, Roh KH, Park JR et al (2009) Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model. Cytotherapy 11:289–298 281 p following 298

    Article  PubMed  CAS  Google Scholar 

  32. Delay E, Garson S, Tousson G, Sinna R (2009) Fat injection to the breast: technique, results, and indications based on 880 procedures over 10 years. Aesthet Surg J 29:360–376

    Article  PubMed  Google Scholar 

  33. Illouz YG, Sterodimas A (2009) Autologous fat transplantation to the breast: a personal technique with 25 years of experience. Aesthetic Plast Surg 33(5):706–715

    Article  PubMed  Google Scholar 

  34. Wang H, Jiang Y, Meng H, Yu Y, Qi K (2008) Sonographic assessment on breast augmentation after autologous fat graft. Plast Reconstr Surg 122(1):36e–38e

    Article  PubMed  Google Scholar 

  35. Lazzaretti MG, Giovanardi G, Gibertoni F, Cagossi K, Artioli F (2009) A late complication of fat autografting in breast augmentation. Plast Reconstr Surg 123(2):71e–72e

    Article  PubMed  CAS  Google Scholar 

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to James H. Rosing.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rosing, J.H., Wong, G., Wong, M.S. et al. Autologous Fat Grafting for Primary Breast Augmentation: A Systematic Review. Aesth Plast Surg 35, 882–890 (2011). https://doi.org/10.1007/s00266-011-9691-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00266-011-9691-2

Keywords

Navigation