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Can the Use of Hyaluronidase Reduce Capsule Formation?

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Abstract

Background

The purpose of this study was to find whether the use of hyaluronidase reduces capsule formation.

Methods

Ten New Zealand White rabbits were used. Eight pockets were created using an aseptic technique, four on the right side and four on the left side, along the vertebral column of every animal. One piece of silicone from a silicone block was inserted inside every pocket. The dimensions of each piece were 3.5 × 2 × 1.5 cm. In every pocket on the right side of each animal we placed 0.5 ml of hyaluronidase solution. The animals were sacrificed 5 months postoperatively. Capsule formation in the each side of the animals was compared.

Results

Two rabbits presented infection in two pockets and were excluded from the study. There was a statistically significant difference between groups concerning the capsule thickness variable using parametric (P = 0.003) and nonparametric (P = 0.001) analysis [capsule thickness on the right side: 256.46 ± 114.88 (mean ± SD) and on the left side: 369.10 ± 147.81 (mean ± SD); capsule thickness on the right side: 235.69 (104.72) [median (IQR)] and on the left side: 332.12 (188.68) median (IQR)].

Conclusion

The use of hyaluronidase may reduce capsule formation around implants.

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Acknowledgments

We thank Paraskevi Mproumi and Platon Trigkatzis for their help in performing the experiment.

Disclosures

The authors have no commercial interest in the subject of study and no financial or material support.

Author information

Authors and Affiliations

  1. Department of Plastic and Reconstructive Surgery, “G. Gennimata” General Hospital of Athens, Mesogeion Avenue 154, 11527, Athens, Greece

    Georgia-Alexandra Spyropoulou & Dimosthenis Tsoutsos

  2. Experimental-Research Center-ELPEN, Marathonos Avenue 95, Pikermi, Attiki, Greece

    Apostolos Papalois

  3. Department of Pathology, Ioannina University Hospital, 45500, Dourouti, Ioannina, Greece

    Anna Batistatou & Michalis Doukas

Authors
  1. Georgia-Alexandra Spyropoulou
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  2. Apostolos Papalois
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  3. Anna Batistatou
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  4. Michalis Doukas
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  5. Dimosthenis Tsoutsos
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Corresponding author

Correspondence to Georgia-Alexandra Spyropoulou.

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Spyropoulou, GA., Papalois, A., Batistatou, A. et al. Can the Use of Hyaluronidase Reduce Capsule Formation?. Aesth Plast Surg 35, 782–788 (2011). https://doi.org/10.1007/s00266-011-9687-y

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  • DOI: https://doi.org/10.1007/s00266-011-9687-y

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