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LI-RADS v2018: utilizing ancillary features on gadoxetic acid-enhanced MRI to improve the diagnostic performance of small hapatocellular carcinoma (≤ 20 mm)

  • Hepatobiliary
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Abstract

Purpose

To evaluate the role of ancillary features (AFs) of Liver Imaging Reporting and Data System (LI-RADS) in the diagnostic performance of small HCC (≤ 20 mm) on gadoxetic acid-enhanced MRI.

Methods

A total of 154 patients with 183 hepatic observations were analysed in this retrospective study. Observations were categorized using only major features (MFs) and combined MFs and AFs. Independently significant AFs were identified through logistic regression analysis, and upgraded LR-5 criteria were developed using these as new MFs. The diagnostic performance of the modified LI-RADS (mLI-RADS) was calculated and compared with that of LI-RADS v2018 using McNemar’s test.

Results

Restricted diffusion, transitional and hepatobiliary phase hypointensity were independently significant AFs. The mLI-RADS a, c, e, g, h and i (upgraded LR-4 lesions that were categorized using only MFs to LR-5 using a certain or any one, two, three of the above AFs as new MFs) yielded a significantly greater sensitivity than that of the LI-RADS v2018 (68.0%, 69.1%, 69.1%, 69.1%, 69.1%, 68.0% vs. 61.9%, all p < 0.05), whereas the specificities were not significantly different (84.9%, 86.0%, 84.9%, 83.7%, 84.9%, 87.2% vs. 88.4% all p > 0.05). When independently significant AFs were used to upgrade the LR-4 nodules categorized by combined MFs and AFs (mLI-RADS b, d and f), the sensitivities were improved, but the specificities were decreased (all p < 0.05).

Conclusions

Independently significant AFs may be used to upgrade an observation from LR-4 (categorized only using MFs) to LR-5, which can improve diagnostic performance for small HCC.

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Funding

This study was supported by the grants form Tianjin Key Medical Discipline (Specialty) Construction Project (TJYXZDXK-074C), Tianjin Health Science and Technology Project (TJWJ2022QN045), and Tianjin Health Project of Science and Technology (TJWJ2022XK027).

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Author notes

  1. Rong Lyu and Weijuan Hu have contributed equally to this work.

Authors and Affiliations

  1. Department of Radiology, Tianjin Third Central Hospital, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, NO. 83 Jintang Road, Hedong District, Tianjin, 300170, China

    Rong Lyu, Weijuan Hu, Di Wang, Jiao Wang, Zhongsong Gao & Kefeng Jia

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  1. Rong Lyu
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  2. Weijuan Hu
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  3. Di Wang
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  4. Jiao Wang
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  5. Zhongsong Gao
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  6. Kefeng Jia
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Contributions

RL and WH contributed equally to this work. RL: conception, literature research, imaging analysis, manuscript drafting, final manuscript approval. WH: conception, literature research, imaging analysis, manuscript drafting, final manuscript approval. DW: literature research, imaging analysis, manuscript drafting. JW: literature research; data curation; manuscript editing. ZG: data interpretation; literature review; visual abstract. KJ: final manuscript approval.

Corresponding author

Correspondence to Kefeng Jia.

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Lyu, R., Hu, W., Wang, D. et al. LI-RADS v2018: utilizing ancillary features on gadoxetic acid-enhanced MRI to improve the diagnostic performance of small hapatocellular carcinoma (≤ 20 mm). Abdom Radiol 48, 1987–1994 (2023). https://doi.org/10.1007/s00261-023-03871-8

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  • DOI: https://doi.org/10.1007/s00261-023-03871-8

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