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Overview of serum and tissue markers in colorectal cancer: a primer for radiologists

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Abstract

Serum and tissue tumor markers provide crucial information in the diagnosis, treatment, and follow-up of colorectal cancers. Tissue tumor markers are increasingly used for determination of targeted chemotherapy planning based on genotyping of tumor cells. Recently, plasma-based technique of liquid biopsy is being evaluated for providing tumor biomarkers in the management of colorectal cancer. Tumor markers are commonly used in conjunction with imaging during initial staging, treatment determination, response assessment, and determination of recurrence or metastatic disease. Knowledge of tumor markers and their association with radiological findings is thus crucial for radiologists. Additionally, various novel imaging techniques are being evaluated as potential noninvasive imaging biomarkers to predict tumor genotypes, features, and tumor response. We review and discuss the potential role of these newer imaging techniques.

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Authors and Affiliations

  1. Department of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA

    Apurva Bonde

  2. Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH, 44106, USA

    Daniel A. Smith, Elias Kikano, Sree H. Tirumani & Nikhil H. Ramaiya

  3. Department of Pathology, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH, 44106, USA

    Jennifer M. Yoest

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  1. Apurva Bonde
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  2. Daniel A. Smith
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Bonde, A., Smith, D.A., Kikano, E. et al. Overview of serum and tissue markers in colorectal cancer: a primer for radiologists. Abdom Radiol 46, 5521–5535 (2021). https://doi.org/10.1007/s00261-021-03243-0

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  • DOI: https://doi.org/10.1007/s00261-021-03243-0

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