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The effect of tumor location on long-term results of microwave ablation for early-stage hepatocellular carcinoma

  • Interventional Radiology
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Abdominal Radiology Aims and scope Submit manuscript

Abstract

Background

To analyze the influence of tumor location, including tumor adjacency and located segments on long-term survival outcomes for patients with solitary hepatocellular carcinoma (HCC) after microwave ablation (MWA).

Methods

This retrospective study evaluated 850 patients. The hepatic segments where the tumor is located, tumor adjacency (important tissues adjacent to tumor) and other clinical characteristics were collected. Overall survival (OS), local tumor progression (LTP) and disease-free survival (DFS) were compared and analyzed. Influence of tumor location was evaluated by multi-models and the effect of adjacency for OS, LTP, and DFS in different segments was analyzed by stratification analysis.

Results

The OS, LTP, and DFS rates were similar in different hepatic segments, so were in high risk and safe locations. In multi-models, HCC in segment 8 showed lower death rate of 43% than that in segment 2 (HR 0.57; P = 0.01) and tumors in segment 6 seemed to have lower LTP rate. Tumors in high-risk locations were risk factors for OS, LTP, and DFS compared with tumors in safe locations, but all differences were not significant in different models. The effects of tumor adjacency on survival outcomes among subgroups of segments were limited.

Conclusion

The tumor adjacency was not a prognostic factor of survival outcomes for patients with solitary tumors after MWA, but tumors in segment 8 seemed to better OS rate than tumors in other segments.

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Acknowledgements

This work was supported by Grant 2017YFC0112000 and 2018ZX10723-204 from the National Key R&D Program of Ministry of Science and Technology of China, Grants 81627803,81622024 and 81801722 from the National Scientific Foundation Committee of China.

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Authors and Affiliations

  1. Department of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China

    Jian-ping Dou, Zhi-yu Han, Zhi-gang Cheng, Fang-yi Liu, Xiao-ling Yu, Jie Yu & Ping Liang

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  1. Jian-ping Dou
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  2. Zhi-yu Han
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  3. Zhi-gang Cheng
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  4. Fang-yi Liu
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  5. Xiao-ling Yu
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  6. Jie Yu
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  7. Ping Liang
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Contributions

PL, JY, JD: Concept and design. JD, JY: Experiments and procedures: All authors. Writing of article. JD: Statistical analysis.

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Correspondence to Jie Yu or Ping Liang.

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All authors declared that they do not have anything to disclose regarding funding or conflict of interest with respect to this manuscript.

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Dou, Jp., Han, Zy., Cheng, Zg. et al. The effect of tumor location on long-term results of microwave ablation for early-stage hepatocellular carcinoma. Abdom Radiol 45, 3923–3933 (2020). https://doi.org/10.1007/s00261-020-02472-z

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