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Clear cell carcinoma of the ovary: comparison of MR findings of histological subtypes

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Abstract

Purpose

To retrospectively compare the MR findings of histological subtypes of clear cell carcinomas (CCCs) of the ovary.

Materials and methods

This single-center retrospective study was approved by the institutional review board, and the requirement for informed consent was waived. Between April 2005 and August 2015, we found 51 consecutive patients with histopathologically proven CCCs. Among them, 44 CCCs in 37 patients who underwent preoperative MR imaging were included. CCCs were pathologically divided into three subgroups: (1) four clear cell adenofibroma-associated CCCs, (2) 21 endometriosis-associated CCCs, and (3) 19 indeterminate CCCs. The statistical tests were used to compare the frequency of qualitative assessments and value of quantitative measurements among the histological subtypes.

Results

On T2-weighted images, hypointense areas within solid components were more frequently observed in clear cell adenofibroma-associated CCCs [3/4 (75%)] than in the remaining CCCs [1/40 (3%)] (p < 0.01), and the signal intensity ratios (SIRs) of solid components were significantly lower in clear cell adenofibroma-associated CCCs (0.27 ± 0.13) than in the remaining CCCs (0.61 ± 0.18) (p < 0.01). On T1-weighted images, hyperintensities of cystic components were more frequently observed in the endometriosis-associated CCCs [17/21 (81%)] than in the remaining CCCs [5/20 (25%)] (p < 0.01), and the SIRs of cystic components were significantly higher in endometriosis-associated CCCs (2.99 ± 1.51) than in the remaining CCCs (1.82 ± 1.10) (p < 0.01).

Conclusion

MR features may help differentiate between adenofibroma-associated and endometriosis-associated CCC.

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Authors and Affiliations

  1. Department of Radiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan

    Hiroki Kato & Masayuki Matsuo

  2. Department of Pathology, Gifu University School of Medicine, Gifu, Japan

    Yuichiro Hatano

  3. Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu, Japan

    Hiroshi Makino, Tatsuro Furui & Ken-ichirou Morishige

Authors
  1. Hiroki Kato
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  2. Yuichiro Hatano
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  3. Hiroshi Makino
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  4. Tatsuro Furui
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  5. Ken-ichirou Morishige
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  6. Masayuki Matsuo
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Corresponding author

Correspondence to Hiroki Kato.

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Conflicts of interest

The authors declare that there is no conflict of interest associated with this article.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Informed consent

This study was approved by our institutional review board and complied with the guidelines of the Healthcare Insurance Portability and Accountability Act. Written informed consent was waived because this study was retrospective.

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Kato, H., Hatano, Y., Makino, H. et al. Clear cell carcinoma of the ovary: comparison of MR findings of histological subtypes. Abdom Radiol 41, 2476–2483 (2016). https://doi.org/10.1007/s00261-016-0777-9

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  • DOI: https://doi.org/10.1007/s00261-016-0777-9

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