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MDCT and MRI of the ampulla of Vater (part II): non-epithelial neoplasms, benign ampullary disorders, and pitfalls

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Abstract

The purpose of this two-part article is to review the cross-sectional imaging features of benign and malignant ampullary conditions with endoscopic and histopathologic correlation and to present the most common pitfalls in the evaluation of the ampulla. In this part, we will review the mesenchymal and secondary neoplasms of the ampulla, a vast array of benign ampullary conditions, causes of bulging papilla, and pitfalls. Familiarity with ampullary pathologic conditions and pitfalls, as well as the use of optimized MDCT and MRI techniques, may improve the diagnostic accuracy of radiologists facing ampullary abnormalities.

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References

  1. Albores-Saavedra J, Henson DE, Klimstra DS (2000) Tumors of the ampullary region. In: Albores-Saavedra J, Henson DE, Klimstra DS (eds) Tumors of the pancreas: AFIP atlas of tumor pathology third series. Washington: American Registry of Pathology, pp 245–358

    Google Scholar 

  2. Bosman FT, Carneiro F, Hruban RH, Theise ND (2010) World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System, 4th edn. Lyon, France: IARC Press

    Google Scholar 

  3. Kobayashi M, Hirata N, Nakaji S, et al. (2014) Gastrointestinal stromal tumor of the ampulla of Vater: a case report. World J Gastroenterol 20(16):4817–4821

    Article  PubMed Central  PubMed  Google Scholar 

  4. Tateishi U, Miyake M, Maeda T, et al. (2006) CT and MRI findings in KIT-weak or KIT-negative atypical gastrointestinal stromal tumors. Eur Radiol 16(7):1537–1543

    Article  PubMed  Google Scholar 

  5. Nikolaidis P, Hammond NA, Day K, et al. (2014) Imaging features of benign and malignant ampullary and periampullary lesions. Radiographics 34(3):624–641

    Article  PubMed  Google Scholar 

  6. Yu MH, Lee JM, Baek JH, Han JK, Choi BI (2014) MRI features of gastrointestinal stromal tumors. AJR 203(5):980–991

    Article  PubMed  Google Scholar 

  7. Kang HC, Menias CO, Gaballah AH, et al. (2013) Beyond the GIST: mesenchymal tumors of the stomach. Radiographics 33(6):1673–1690

    Article  PubMed Central  PubMed  Google Scholar 

  8. Jayaraman MV, Mayo-Smith WW, Movson JS, Dupuy DE, Wallach MT (2001) CT of the duodenum: an overlooked segment gets its due. Radiographics 21:S147–160

    Article  PubMed  Google Scholar 

  9. Sriram PV, Weise C, Seitz U, et al. (2000) Lymphangioma of the major duodenal papilla presenting as acute pancreatitis: treatment by endoscopic snare papillectomy. Gastrointest Endosc 51(6):733–736

    Article  CAS  PubMed  Google Scholar 

  10. Choi JY, Kim MJ, Chung JJ, et al. (2002) Gallbladder lymphangioma: MR findings. Abdom Imaging 27(1):54–57

    Article  PubMed  Google Scholar 

  11. Papp R, Baracs J, Papp A, et al. (2013) Ganglioneuroma in the papilla of Vater with neurofibromatosis type 1: report of a case. Surg Today 43(6):675–677

    Article  PubMed  Google Scholar 

  12. Kim S, Lee NK, Lee JW, et al. (2007) CT evaluation of the bulging papilla with endoscopic correlation. Radiographics 27(4):1023–1038

    Article  PubMed  Google Scholar 

  13. Iwamuro M, Kawai Y, Takata K, et al. (2013) Primary intestinal follicular lymphoma: how to identify follicular lymphoma by routine endoscopy. World J Gastrointest Endosc 5(1):34–38

    Article  PubMed Central  PubMed  Google Scholar 

  14. Seitz JF, Giovannini M, Wartelle C, et al. (1990) Kaposi’s sarcoma of Vater’s ampulla associated with sclerosing cholangitis caused by cryptosporidium in a patient. Gastroenterol Clin Biol 14(11):889–891

    CAS  PubMed  Google Scholar 

  15. Khalaf A, Heller MT (2014) Extra-skeletal osteosarcoma presenting as a peri-ampullary mass. J Gastrointest Cancer 45(1):103–105

    Article  PubMed  Google Scholar 

  16. Perera MT, McKiernan PJ, Brundler MA, et al. (2009) Embryonal rhabdomyosarcoma of the ampulla of Vater in early childhood: report of a case and review of literature. J Pediatr Surg 44(2):e9–11

    Article  PubMed  Google Scholar 

  17. Kim TU, Kim S, Lee JW, et al. (2008) Ampulla of Vater: comprehensive anatomy, MR imaging of pathologic conditions, and correlation with endoscopy. Eur J Radiol 66(1):48–64

    Article  PubMed  Google Scholar 

  18. Veldkamp MC, Rauws EA, Dijkgraaf MG, Fockens P, Bruno MJ (2007) Iatrogenic ampullary stenosis: history, endoscopic management, and outcome in a series of 49 patients. Gastrointest Endosc 66(4):708–716

    Article  PubMed  Google Scholar 

  19. Sgouros SN, Pereira SP (2006) Systematic review: sphincter of Oddi dysfunction–non-invasive diagnostic methods and long-term outcome after endoscopic sphincterotomy. Aliment Pharmacol Ther 24(2):237–246

    Article  CAS  PubMed  Google Scholar 

  20. Corazziari E (2003) Sphincter of oddi dysfunction. Dig Liver Dis 35(3):S26–S29

    Article  PubMed  Google Scholar 

  21. Katabathina VS, Dasyam AK, Dasyam N, Hosseinzadeh K (2014) Adult bile duct strictures: role of MR imaging and MR cholangiopancreatography in characterization. Radiographics 34(3):565–586

    Article  PubMed  Google Scholar 

  22. Aisen AM, Sherman S, Jennings SG, et al. (2008) Comparison of secretin-stimulated magnetic resonance pancreatography and manometry results in patients with suspected sphincter of oddi dysfunction. Acad Radiol 15(5):601–619

    Article  PubMed  Google Scholar 

  23. Samardar P (2002) The pseudocalculus sign. Radiology 223(1):239–240

    Article  PubMed  Google Scholar 

  24. Hosoki T, Hasuike Y, Takeda Y, et al. (2004) Visualization of pancreaticobiliary reflux in anomalous pancreaticobiliary junction by secretin-stimulated dynamic magnetic resonance cholangiopancreatography. Acta Radiol 45(4):375–382

    Article  CAS  PubMed  Google Scholar 

  25. Sugiyama M, Baba M, Atomi Y, et al. (1998) Diagnosis of anomalous pancreaticobiliary junction: value of magnetic resonance cholangiopancreatography. Surgery 123(4):391–397

    Article  CAS  PubMed  Google Scholar 

  26. Haber GB (2007) Ampullary and biliary stenosis: a delayed sphincterotomy complication–easy to forget, tough to treat. Gastrointest Endosc 66(4):717–719

    Article  PubMed  Google Scholar 

  27. Chang S, Lim JH, Choi D, Kim SK, Lee WJ (2008) Differentiation of ampullary tumor from benign papillary stricture by thin-section multidetector CT. Abdom Imaging 33(4):457–462

    Article  PubMed  Google Scholar 

  28. Chung YE, Kim MJ, Kim HM, et al. (2011) Differentiation of benign and malignant ampullary obstructions on MR imaging. Eur J Radiol 80(2):198–203

    Article  PubMed  Google Scholar 

  29. Nishimori I, Otsuki M (2009) Autoimmune pancreatitis and IgG4-associated sclerosing cholangitis. Best Pract Res Clin Gastroenterol 23(1):11–23

    Article  CAS  PubMed  Google Scholar 

  30. Parlak E, Dişibeyaz S, Odemiş B, et al. (2012) Demonstration of retraction of the main papilla toward the biliary system in patients with primary sclerosing cholangitis with magnetic resonance cholangiopancreatography. Dig Endosc 24(5):384

    Article  PubMed  Google Scholar 

  31. Schneiderman DJ, Cello JP, Laing FC (1987) Papillary stenosis and sclerosing cholangitis in the acquired immunodeficiency syndrome. Ann Intern Med 106(4):546–549

    Article  CAS  PubMed  Google Scholar 

  32. Tonolini M, Bianco R (2013) HIV-related/AIDS cholangiopathy: pictorial review with emphasis on MRCP findings and differential diagnosis. Clin Imaging 37(2):219–226

    Article  PubMed  Google Scholar 

  33. Vitellas KM, Keogan MT, Freed KS, et al. (2000) Radiologic manifestations of sclerosing cholangitis with emphasis on MR cholangiopancreatography. Radiographics 20(4):959–975

    Article  CAS  PubMed  Google Scholar 

  34. Salvia R, Fernandez-del Castillo C, Bassi C, et al. (2004) Main-duct intraductal papillary mucinous neoplasms of the pancreas: clinical predictors of malignancy and long-term survival following resection. Ann Surg 239:678–685

    Article  PubMed Central  PubMed  Google Scholar 

  35. Beintaris I, Polymeros D, Krivan S, Triantafyllou K (2013) Fish-mouth appearance of the ampulla of Vater. Ann Gastroenterol 26(1):73

    PubMed Central  PubMed  Google Scholar 

  36. Mortelé KJ (2013) Cystic pancreatic neoplasms: imaging features and management strategy. Semin Roentgenol 48(3):253–263

    Article  PubMed  Google Scholar 

  37. Kawamoto S, Horton KM, Lawler LP, et al. (2005) Intraductal papillary mucinous neoplasm of the pancreas: can benign lesions be differentiated from malignant lesions with multidetector CT? Radiographics 25(6):1451–1468

    Article  PubMed  Google Scholar 

  38. Taouli B, Vilgrain V, Vullierme MP, et al. (2000) Intraductal papillary mucinous tumors of the pancreas: helical CT with histopathologic correlation. Radiology 217(3):757–764

    Article  CAS  PubMed  Google Scholar 

  39. Kawamoto S, Lawler LP, Horton KM, et al. (2006) MDCT of intraductal papillary mucinous neoplasm of the pancreas: evaluation of features predictive of invasive carcinoma. AJR 186(3):687–695

    Article  PubMed  Google Scholar 

  40. Irie H, Honda H, Aibe H, et al. (2000) MR cholangio-pancreatography differentiation of benign and malignant intraductal mucin-producing tumors of the pancreas. AJR 174(5):1403–1408

    Article  CAS  PubMed  Google Scholar 

  41. Arakawa A, Yamashita Y, Namimoto T, et al. (2000) Intraductal papillary tumors of the pancreas. Histopathologic correlation of MR cholangio pancreatography findings. Acta Radiol 41(4):343–347

    Article  CAS  PubMed  Google Scholar 

  42. Todani T, Watanabe Y, Narusue M, Tabuchi K, Okajima K (1977) Congenital bile duct cysts: classification, operative procedures, and review of thirty-seven cases including cancer arising from choledochal cyst. Am J Surg 134(2):263–269

    Article  CAS  PubMed  Google Scholar 

  43. Law R, Topazian M (2014) Diagnosis and treatment of choledochoceles. Clin Gastroenterol Hepatol 12(2):196–203

    Article  PubMed  Google Scholar 

  44. Mortelé KJ, Rocha TC, Streeter JL, Taylor AJ (2006) Multimodality imaging of pancreatic and biliary congenital anomalies. Radiographics 26(3):715–731

    Article  PubMed  Google Scholar 

  45. Chang JH, Lee IS, Lim YS, et al. (2012) Role of magnetic resonance cholangiopancreatography for choledocholithiasis: analysis of patients with negative MRCP. Scand J Gastroenterol 47(2):217–224

    Article  PubMed  Google Scholar 

  46. Romagnuolo J, Bardou M, Rahme E, et al. (2003) Magnetic resonance cholangiopancreatography: a meta-analysis of test performance in suspected biliary disease. Ann Intern Med 139(7):547–557

    Article  PubMed  Google Scholar 

  47. Anderson SW, Rho E, Soto JA (2008) Detection of biliary duct narrowing and choledocholithiasis: accuracy of portal venous phase multidetector CT. Radiology 247(2):418–427

    Article  PubMed  Google Scholar 

  48. Tseng CW, Chen CC, Chen TS, et al. (2008) Can computed tomography with coronal reconstruction improve the diagnosis of choledocholithiasis? J Gastroenterol Hepatol 23(10):1586–1589

    Article  PubMed  Google Scholar 

  49. Zoepf T, Zoepf DS, Arnold JC, Benz C, Riemann JF (2001) The relationship between juxtapapillary duodenal diverticula and disorders of the biliopancreatic system: analysis of 350 patients. Gastrointest Endosc 54(1):56–61

    Article  CAS  PubMed  Google Scholar 

  50. Egawa N, Anjiki H, Takuma K, Kamisawa T (2010) Juxtapapillary duodenal diverticula and pancreatobiliary disease. Dig Surg 27(2):105–159

    Article  PubMed  Google Scholar 

  51. Uomo G, Manes G, Ragozzino A, Cavallera A, Rabitti PG (1996) Periampullary extraluminal duodenal diverticula and acute pancreatitis: an underestimated etiological association. Am J Gastroenterol 91:1186–1188

    CAS  PubMed  Google Scholar 

  52. Gong J, Zhao H, Liu T, Ling R, Xu J (2009) Value of MRCP using oral Gd-DTPA as negative contrast materials in diagnosis of atypical juxtapapillary duodenal diverticulum. Clin Imaging 33(5):361–364

    Article  PubMed  Google Scholar 

  53. Balci NC, Akinci A, Akün E, Klör HU (2003) Juxtapapillary diverticulum: findings on CT and MRI. Clin Imaging 27(2):82–88

    Article  PubMed  Google Scholar 

  54. Saranovic D, Djuric-Stefanovic A, Milovanovic A, et al. (2009) Education and imaging. Hepatobiliary and pancreatic: juxtapapillary duodenal diverticulum causing cholestasis. J Gastroenterol Hepatol 24(3):496

    Article  CAS  PubMed  Google Scholar 

  55. Jang KM, Kim SH, Park HJ, et al. (2013) Ectopic pancreas in upper gastrointestinal tract: MRI findings with emphasis on differentiation from submucosal tumor. Acta Radiol 54(10):1107–1116

    Article  PubMed  Google Scholar 

  56. Dolan RV, ReMine WH, Dockerty MB (1974) The fate of heterotopic pancreatic tissue. A study of 212 cases. Arch Surg 109:762–765

    Article  CAS  PubMed  Google Scholar 

  57. Hsu SD, Chan DC, Hsieh HF, et al. (2008) Ectopic pancreas presenting as ampulla of Vater tumor. Am J Surg 195(4):498–500

    Article  PubMed  Google Scholar 

  58. Wang C, Kuo Y, Yeung K, Wu C, Liu G (1998) CT appearance of ectopic pancreas: a case report. Abdom Imaging 23(3):332–333

    Article  CAS  PubMed  Google Scholar 

  59. Rao RN, Kamlesh Y, Pallav G, Singla N (2011) Ectopic pancreas presenting as periampullary tumor with obstructive jaundice and pruritus is a rare diagnostic and therapeutic dilemma. A case report. JOP 12(6):607–609

    PubMed  Google Scholar 

  60. Hur S, Han JK, Kim MA, Bae JM, Choi BI (2010) Brunner’s gland hamartoma: computed tomographic findings with histopathologic correlation in 9 cases. J Comput Assist Tomogr 34(4):543–547

    Article  PubMed  Google Scholar 

  61. Patel ND, Levy AD, Mehrotra AK, Sobin LH (2006) Brunner’s gland hyperplasia and hamartoma: imaging features with clinicopathologic correlation. AJR 187(3):715–722

    Article  PubMed  Google Scholar 

  62. Ohba R, Otaka M, Jin M, et al. (2007) Large Brunner’s gland hyperplasia treated with modified endoscopic submucosal dissection. Dig Dis Sci 52(1):170–172

    Article  PubMed  Google Scholar 

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Correspondence to Francesco Alessandrino.

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Alessandrino, F., Souza, D., Ivanovic, A.M. et al. MDCT and MRI of the ampulla of Vater (part II): non-epithelial neoplasms, benign ampullary disorders, and pitfalls. Abdom Imaging 40, 3292–3312 (2015). https://doi.org/10.1007/s00261-015-0529-2

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