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A review of the general aspects of radiofrequency ablation

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Abstract

As an alternative to standard surgical resection for the treatment of malignant tumors, radiofrequency ablation (RFA) has rapidly evolved into the most popular minimally invasive therapy. To help readers gain the relevant background knowledge and to better understand the other reviews in this Feature Section on the clinical applications of RFA in different abdominal organs, the present report covers the general aspects of RFA. After an introduction, we present a simple definition of the energy applied during RFA, a brief historical review of its technical evolution, and an explanation of the mechanism of action of RFA. These basic discussions are substantiated with descriptions of RFA equipment including those commercially available and those under preclinical development. The size and geometry of induced lesions in relation to RFA efficacy and side effects are discussed. The unique pathophysiologic process of thermal tissue damage and the corresponding histomorphologic manifestations after RFA are detailed and cross-referenced with the findings in the current literature. The crucial role of imaging technology during and after RFA is also addressed, including some promising new developments. This report finishes with a summary of the key messages and a perspective on further technologic refinements and identifies some specific priorities.

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Authors and Affiliations

  1. Department of Radiology, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, B-3000, Leuven, Belgium

    Y. Ni & G. Marchal

  2. Department of Surgery, University Hospital of Mont-Godinne, Catholic University of Louvain, Avenue du Dr. Thérass 1, B-5530, Yvoir, Belgium

    S. Mulier & L. Michel

  3. Department of General Surgery, University Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, China

    Y. Miao

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Correspondence to Y. Ni.

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Ni, Y., Mulier, S., Miao, Y. et al. A review of the general aspects of radiofrequency ablation. Abdom Imaging 30, 381–400 (2005). https://doi.org/10.1007/s00261-004-0253-9

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