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Current research topics in FAPI theranostics: a bibliometric analysis

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

The study aimed to provide a comprehensive bibliometric overview of the current scientific publications on fibroblast activation protein inhibitor (FAPI) positron emission tomography imaging and radionuclide therapy.

Methods

A PubMed search was performed to identify all MEDLINE-indexed publications on FAPI imaging and radionuclide therapy. The last update was performed on 31 May 2022. An online database of this literature was created, and hierarchical topic-related tags were subsequently assigned to all relevant studies. Frequency analysis was used to evaluate the distribution of the following characteristics: first author’s country of origin, journal of publication, study design, imaging techniques and radiopharmaceutical used, histopathological correlation, the type of cancer, and benign disease/uptake types evaluated.

Results

A total of 294 relevant publications on original studies were identified, consisting of 209 (71%) case reports/series and 85 cohort studies (29%). The majority of studies focused on imaging topics, predominantly comparing uptake on FAPI-PET/CT with 2-[18F]FDG-PET/CT, anatomical imaging, and/or histopathology results. 68% of studies focused on malignancies, with gastro-intestinal cancer, hepato-pancreato-biliary cancer, mixed cancers/metastases, lung cancer, sarcoma, head and neck cancer, and breast cancer being the most frequently reported. 42% of studies focused on benign disease categories, with cardiovascular, musculoskeletal, HPB, head and neck, and IgG4-related disease as most common categories. 16/294 (5%) studies focused on radionuclide therapy, with preliminary reports of acceptable toxicity profiles, tumour activity retention, and suggestion of disease control.

Conclusion

FAPI research is rapidly expanding from diagnostic studies in malignancies and benign diseases to the first reports of salvage radionuclide therapy. The research activity needs to shift now from low-level-of-evidence case reports and series to prospectively designed studies in homogenous patient groups to provide evidence on how and in which clinical situations FAPI theranostics can be of added value to clinical care. We have provided an overview of current research topics to build upon.

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Data availability

The literature database is available in the supplementary materials.

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  1. Department of Nuclear Medicine, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands

    Andor F. van den Hoven, Ruth G. M. Keijsers & Jules Lavalaye

  2. Department of Radiology and Nuclear Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands

    Marnix G. E. H. Lam

  3. Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands

    Andor W. J. M. Glaudemans

  4. Department of Radiology and Nuclear Medicine, Erasmus Medical Centre, Rotterdam, Netherlands

    Frederik A. Verburg

  5. Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands

    Wouter V. Vogel

  6. Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

    Wouter V. Vogel

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Andor van den Hoven performed the literature search, topic categorization, and bibliometric analysis. The first draft of the manuscript was written by Andor van den Hoven, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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van den Hoven, A.F., Keijsers, R.G.M., Lam, M.G.E.H. et al. Current research topics in FAPI theranostics: a bibliometric analysis. Eur J Nucl Med Mol Imaging 50, 1014–1027 (2023). https://doi.org/10.1007/s00259-022-06052-9

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