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EANM/ESC guidelines for radionuclide imaging of cardiac function

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  • Published:
European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Radionuclide imaging of cardiac function represents a number of well-validated techniques for accurate determination of right (RV) and left ventricular (LV) ejection fraction (EF) and LV volumes. These first European guidelines give recommendations for how and when to use first-pass and equilibrium radionuclide ventriculography, gated myocardial perfusion scintigraphy, gated PET, and studies with non-imaging devices for the evaluation of cardiac function. The items covered are presented in 11 sections: clinical indications, radiopharmaceuticals and dosimetry, study acquisition, RV EF, LV EF, LV volumes, LV regional function, LV diastolic function, reports and image display and reference values from the literature of RVEF, LVEF and LV volumes. If specific recommendations given cannot be based on evidence from original, scientific studies, referral is given to “prevailing or general consensus”. The guidelines are designed to assist in the practice of referral to, performance, interpretation and reporting of nuclear cardiology studies for the evaluation of cardiac performance.

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Abbreviations

ACD:

acid citrate dextrose

CAD:

coronary artery disease

cMRI:

cardiac magnetic resonance imaging

ECG:

electrocardiogram

ECT:

Emory Cardiac Toolbox

ED:

end-diastolic

EDV:

end-diastolic volume

ES:

end-systolic

EF:

ejection fraction

ERNV:

equilibrium radionuclide ventriculography

ESV:

end-systolic volume

FP:

first pass

FPRNV:

first-pass radionuclide ventriculography

HSA:

human serum albumin

i.v.:

intravenous

LAO:

left anterior oblique

LBBB:

left bundle branche block

LEGP:

low energy general purpose

LEHR:

low energy high resolution

LEHS:

low energy high sensitivity

LPO:

left posterior oblique

LV:

left ventricle

LVV:

left ventricular volume

LVEF:

left ventricular ejection fraction

MI:

myocardial infarction

MPS:

myocardial perfusion scintigraphy

NSTEMI:

non-ST elevation acute myocardial infarction

PFR:

peak filling rate

PFRSV :

PFR normalised to stroke volume

QGS:

quantitative gated SPECT

RAO:

right anterior oblique

RBC:

red blood cells

RNV:

radionuclide ventriculography

ROI:

region-of-interest

RV:

right ventricle

STEMI:

ST elevation acute myocardial infarction

TAC:

time-activity curve

TID:

transient ischaemic dilatation

TPFR:

time to peak filling rate

WM:

wall motion

WTh:

wall thickening

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Acknowledgement

We wish to thank Jenny Sandgren for her devoted efforts with very skillful secretarial assistance.

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Authors and Affiliations

  1. Department of Clinical Physiology and Nuclear Medicine, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark

    B. Hesse, A. Kjaer & J. Marving

  2. Department of Cardiology, Hilleroed Hospital, Hilleroed, Denmark

    T. B. Lindhardt

  3. Department of Biomorphological and Functional Sciences, Institute of Biostructure and Bioimages of the National Council of Research, University of Naples Federico II, Naples, Italy

    W. Acampa

  4. Department of Nuclear Medicine, Royal Brompton Hospital, London, UK

    C. Anagnostopoulos & A. F. Maenhout

  5. Department of Nuclear Medicine, Guy’s Hospital-Guy’s and St. Thomas’ Foundation Trust, St. Thomas Street, London, UK

    J. Ballinger

  6. Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands

    J. J. Bax

  7. Department of Clinical Sciences, Malmö, Lund University Research Program in Medical Informatics, Malmö University Hospital, Malmö, Sweden

    L. Edenbrandt

  8. Nuclear Medicine Department, Autonomous University of Barcelona, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

    A. Flotats

  9. Artificial Intelligence Program at Cedars-Sinai Medical Center and Department of Medicine of the University of California at Los Angeles, Los Angeles, USA

    G. Germano

  10. Department of Nuclear Medicine, University Medical Centre Ljubljana, Radiopharmacy and Clinical Biochemistry, Ljubljana, Zaloska 7, Slovenia

    T. Gmeiner Stopar

  11. Nuclear Medicine, AZ VUB, Brussels, Belgium

    P. Franken

  12. Nuclear Medicine Department, Harefield Hospital, Harefield, Middlesex, UK

    A. Kelion

  13. Service de medecine nucleaire, hôpital Bichat, APHP, Université Denis-Diderot, UMR577B, and Inserm U773, Paris, France

    D. Le Guludec

  14. Medical Radiation Physics, Clinical Sciences, Lund, Lund University, Lund, Sweden

    M. Ljungberg

  15. Department of Cardiology, Fondazione Maugeri, IRCCS, Veruno, Italy

    C. Marcassa

  16. Nuclear Medicine Department, Aberdeen Royal Infirmary, Foresterhill Aberdeen, Scotland, UK

    F. McKiddie

  17. Nuclear Medicine Department, University Hospital, Aachen University of Technology, Aachen, Germany

    W. M. Schaefer

  18. Department of Nuclear Medicine, University Hospital Münster, Münster, Germany

    L. Stegger

  19. Department of Nuclear Medicine, Royal Brompton Hospital, London, UK

    R. Underwood

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  1. B. Hesse
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  2. T. B. Lindhardt
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  22. R. Underwood
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Correspondence to B. Hesse.

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Hesse, B., Lindhardt, T.B., Acampa, W. et al. EANM/ESC guidelines for radionuclide imaging of cardiac function. Eur J Nucl Med Mol Imaging 35, 851–885 (2008). https://doi.org/10.1007/s00259-007-0694-9

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