Abstract
Purpose
We have previously demonstrated the efficacy of intracoronary β-brachytherapy using a liquid 188Re-filled balloon in a randomised trial including de novo lesions. Percutaneous coronary interventions in restenotic lesions and in stenoses of venous bypass grafts are characterised by a high recurrence rate for restenosis and re-interventions. Against this background, we wanted to assess the impact of intracoronary β-brachytherapy using a liquid 188Re-filled balloon in restenotic lesions in native coronary arteries and venous bypass grafts.
Methods
In 243 patients, β-brachytherapy with 22.5 Gy was applied at a tissue depth of 0.5 mm. Patients were followed up angiographically after 6 months and clinically for 12 months. The primary clinical endpoint was the incidence of MACE (death, myocardial infarction, target vessel revascularisation). Secondary angiographic endpoints were late loss and binary restenosis rate in the total segment.
Results
All irradiation procedures were successfully performed. A total of 222 lesions were in native coronary arteries; 21 were bypass lesions. Mean irradiation length was 41.6±17.3 mm (range 20–150 mm) in native coronary arteries and 48.1±33.9 mm (range 30–180 mm) in bypass lesions; the reference diameter was 2.57±0.52 mm and 2.83±0.76 mm, respectively. There was no vessel thrombosis during antiplatelet therapy. Angiographic/clinical follow-up rate was 84%/100%. MACE rate was 17.6% in the native coronary artery group and 38.1% in the CABG group (p<0.03). Binary restenosis rate was 22.5% and 55.6% (p<0.01), and late loss was 0.38±0.72 mm and 1.33±1.11 mm (p<0.001), respectively.
Conclusions
We conclude that intracoronary β-brachytherapy with a liquid 188Re-filled balloon using 22.5 Gy at a tissue depth of 0.5 mm in restenotic lesions is safe. It is associated with a low binary restenosis rate, resulting in a low occurrence rate of MACE within 12 months in restenotic lesions in native coronary arteries but not in vein grafts.
Similar content being viewed by others
References
Silber S, Albertsson P, Avilés FF, Camici PG, Colombo A, Hamm C, et al. Guidelines for percutaneous coronary interventions. The Task Force for Percutaneous Coronary Interventions of the European Society of Cardiology. Eur Heart J 2005;26:804–847
Grise MA, Massullo V, Jani S, Popma JJ, Russo RJ, Schatz RA, et al. Five-year clinical follow-up after intracoronary radiation. Results of a randomized clinical trial. Circulation 2002;105:2737–2740
Teirstein PS, Massullo V, Jani S, Popma JJ, Russo RJ, Schatz RA, et al. Three-year clinical and angiographic follow-up after intracoronary radiation: results of a randomized clinical trial. Circulation 2000;101:360–365
Höher M, Wöhrle J, Wohlfrom M, Kamenz J, Nusser T, Grebe OC, et al. Intracoronary beta-irradiation with a rhenium-188-filled balloon catheter: a randomized trial in patients with de novo and restenotic lesions. Circulation 2003;107:3022–3027
Alfonso F, Zueco J, Cequier A, Mantilla R, Bethencourt A, Lopez-Minguez JR, et al. A randomized comparison of repeat stenting with balloon angioplasty in patients with in-stent restenosis. J Am Coll Cardiol 2003;42:796–805
Waksman R, Ajani AE, White RL, Chan RC, Satler LF, Kent KM, et al. Intravascular gamma radiation for in-stent restenosis in saphenous-vein bypass grafts. N Engl J Med 2002;346:1194–1199
Reynen K, Kockeritz U, Kropp J, Wunderlich G, Knapp FF, Schmeisser A, et al. Intracoronary radiotherapy with a (188)rhenium liquid-filled PTCA balloon system in in-stent restenosis: acute and long-term angiographic results, as well as 1-year clinical follow-up. Int J Cardiol 2004;95:29–34
Park SW, Hong MK, Moon DH, Oh SJ, Lee CW, Kim JJ, et al. Treatment of diffuse in-stent restenosis with rotational atherectomy followed by radiation therapy with a rhenium-188-mercaptoacetyltriglycine-filled balloon. J Am Coll Cardiol 2001;38:631–637
Schühlen H, Eigler N, Whiting JS, Haubner R, Hausleiter J, Dirschinger J, et al. Usefulness of intracoronary brachytherapy for in-stent restenosis with a 188Re liquid-filled balloon. Am J Cardiol 2001;87:463–466
Kim KI, Bae J, Kang HJ, Koo BK, Youn TJ, Kim SH, et al. Three-year clinical follow-up results of intracoronary radiation therapy using a rhenium-188-diethylene-triamine-penta-acetic-acid-filled balloon system. Circ J 2004;68:532–537
Höher M, Wöhrle J, Wohlfrom M, Hanke H, Voisard R, Osterhues HH, et al. Intracoronary β-irradiation with a liquid 188Re-filled balloon six-month results from a clinical safety and feasibility study. Circulation 2000;101:2355–2360
Teirstein PS, Massullo V, Jani S, Popma JJ, Mintz GS, Russo RJ, et al. Catheter-based radiotherapy to inhibit restenosis after coronary stenting. N Engl J Med 1997;336:1697–1703
Leon MB, Teirstein PS, Moses JW, Tripuraneni P, Lansky AJ, Jani S, et al. Localized intracoronary gamma-radiation therapy to inhibit the recurrence of restenosis after stenting. N Engl J Med 2001;344:250–256
Waksman R, White RL, Chan RC, Bass BG, Geirlach L, Mintz GS, et al. Intracoronary gamma-radiation therapy after angioplasty inhibits recurrence in patients with in-stent restenosis. Circulation 2000;101:2165–2171
Waksman R, Cheneau E, Ajani AE, White L, Pinnow E, Torguson R, et al. Intracoronary radiation therapy improves the clinical and angiographic outcomes of diffuse in-stent restenotic lesions: results of the Washington Radiation for In-Stent Restenosis Trial for Long Lesions (Long WRIST) studies. Circulation 2003;107:1744–1749
Popma JJ, Suntharalingam M, Lansky AJ, Heuser RR, Speiser B, Teirstein PS, et al. for the stents and radiation therapy (START) investigators randomized trial of 90Sr/90Y β-radiation versus placebo control for treatment of in-stent restenosis. Circulation 2002;106:1090–1096
Waksman R, Bhargava B, White L, Chan RC, Mehran R, Lansky AJ, et al. Intracoronary β-radiation therapy inhibits recurrence of in-stent restenosis. Circulation 2000;101:1895–1898
Lee SW, Park SW, Hong MK, Kim YH, Lee JH, Park JH, et al. Long-term outcomes after treatment of diffuse in-stent restenosis with rotational atherectomy followed by beta-radiation therapy with a 188Re-MAG3-filled balloon. Int J Cardiol 2005;99:201–205
Waksman R, Bhargava B, Mintz GS, Mehran R, Lansky AJ, Satler LF, et al. Late total occlusion after intracoronary brachytherapy for patients with in-stent restenosis. J Am Coll Cardiol 2000;36:65–68
Lee SW, Park SW, Hong MK, Kim YH, Han KH, Moon DH, et al. Comparison of angiographic and clinical outcomes between rotational atherectomy and cutting balloon angioplasty followed by radiation therapy with a rhenium 188-mercaptoacetyltriglycine-filled balloon in the treatment of diffuse in-stent restenosis. Am Heart J 2005;150:577–582
Roguelov C, Eeckhout E, De Benedetti E, Coucke P, Silber S, Baumgart D, et al. Clinical outcome following combination of cutting balloon angioplasty and coronary β-radiation for in-stent restenosis: a report from the RENO registry. J Invas Cardiol 2003;15:706–709
Kotzerke J, Rentschler M, Glatting G, Schneider E, Stabin M, Knapp FF Jr, et al. Dosimetry fundamentals of endovascular therapy using Re-188 for the prevention of restenosis after angioplasty. Nuklearmedizin 1998;37:68–72
Kotzerke J, Hanke H, Höher M. Endovascular brachytherapy for the prevention of restenosis after angioplasty. Eur J Nucl Med 2000;27:223–236
Shirai K, Lansky AJ, Mintz GS, Costantini CO, Fahy M, Mehran R, et al. Comparison of the angiographic outcomes after beta versus gamma vascular brachytherapy for treatment of in-stent restenosis. Am J Cardiol 2003;92:1409–1413
Wuu CS, Schiff P, Maryanski MJ, Liu T, Borzillary S, Weinberger J. Dosimetry study of Re-188 liquid balloon for intravascular brachytherapy using polymer gel dosimeters and laser-beam optical CT scanner. Med Phys 2003;130:132–137
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wöhrle, J., Krause, B.J., Nusser, T. et al. Intracoronary β-brachytherapy using a rhenium-188 filled balloon catheter in restenotic lesions of native coronary arteries and venous bypass grafts. Eur J Nucl Med Mol Imaging 33, 1314–1320 (2006). https://doi.org/10.1007/s00259-006-0142-2
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00259-006-0142-2