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Iterative reconstruction with correction of the spatially variant fan-beam collimator response in neurotransmission SPET imaging

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Abstract

The dopamine transporter (DAT) has been shown to be a sensitive indicator of nigrostriatal dopamine function. Although visual inspection is often sufficient to assess DAT imaging, quantification could improve the diagnostic accuracy of single-photon emission tomography (SPET) studies of the dopaminergic system. The aim of this study was to assess the accuracy of quantification of the striatal/background uptake ratio when correction for attenuation, scatter and spatially variant fan-beam collimator response is performed in technetium-99m and iodine-123 SPET imaging. A numerical striatal phantom was implemented, and simulated projections of low-energy photons were obtained by using the SimSET Monte Carlo code. High-energy contamination in 123I studies was modelled from experimental measurements with 99mTc and 123I. The ordered subsets expectation maximisation (OSEM) algorithm was employed in reconstruction. Mean improvements of 8% and 16% were obtained in the calculated striatal/background uptake ratio in the putamen and the caudate, respectively, when the spatially variant point spread function was included in the transition matrix. Ideal scatter correction resulted in improvements in the putamen and caudate of 9% for 99mTc agents and 19% for 123I agents. Improvements averaged 31% in the putamen and 43% in the caudate when correction for attenuation, scatter and spatially variant collimator response was included in the reconstruction.

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Acknowledgements

This work was supported in part by the MCYT (SAF99-0137, SAF2002-04270-C02-01/02) and FIS (PI020485, G03/185, C03/06). D. Pareto was awarded a PhD fellowship by the University of Barcelona.

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Authors and Affiliations

  1. Unitat de Biofísica i Bioenginyeria, Departament de Ciències Fisiològiques I, Facultat de Medicina, Universitat de Barcelona, Casanova 143, 08036 , Barcelona, Spain

    Deborah Pareto, Carles Falcón & Domènec Ros

  2. Servei de Medicina Nuclear, Hospital Clínic, Barcelona, Spain

    Deborah Pareto, Javier Pavía & Francisco Lomeña

  3. Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, Barcelona, Spain

    Albert Cot

  4. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

    Javier Pavía, Francisco Lomeña & Domènec Ros

  5. Serveis Cientifico-Tècnics, Universitat de Barcelona, Barcelona, Spain

    Carles Falcón

  6. Departament de Física Aplicada i Optica, Facultat de Física, Universitat de Barcelona, Barcelona, Spain

    Ignacio Juvells

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  1. Deborah Pareto
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  2. Albert Cot
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  3. Javier Pavía
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  4. Carles Falcón
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  5. Ignacio Juvells
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  6. Francisco Lomeña
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  7. Domènec Ros
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Correspondence to Domènec Ros.

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Pareto, D., Cot, A., Pavía, J. et al. Iterative reconstruction with correction of the spatially variant fan-beam collimator response in neurotransmission SPET imaging. Eur J Nucl Med Mol Imaging 30, 1322–1329 (2003). https://doi.org/10.1007/s00259-003-1229-7

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  • DOI: https://doi.org/10.1007/s00259-003-1229-7

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