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Bizarre parosteal osteocondromatous proliferation (BPOP) of the acromion with soft tissue recurrence

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Abstract

Bizarre parosteal osteochondromatous proliferation (BPOP) is a benign but rare periosteal-originating chondrogenic tumor. It commonly arises from the hands and feet. It is slow-growing and often presents as a painless lump. On imaging, the mass is well-marginated and almost always remains contiguous with the cortical bone. Histologically, the lesion is composed of a disorganized admixture of fibrous tissue, bone, and cartilage with bizarre features. Treatment is surgical and local recurrence is common contiguous with bone. This case report demonstrates an uncommon acromial BPOP with the first reported recurrence not contiguous with the underlying cortex.

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References

  1. Nora FE, Dahlin DC, Beabout JW. Bizarre parosteal osteochondromatous proliferations of the hands and feet. Am J Surg Pathol. 1983;7:245–50. https://doi.org/10.1097/00000478-198304000-0000.

    Article  CAS  PubMed  Google Scholar 

  2. Meneses MF, Unni KK, Swee RG. bizarre parosteal osteochondromatous proliferation of bone (Noraʼs lesion). Am J Surg Pathol. 1993;17:691–7. https://doi.org/10.1097/00000478-199307000-00006.

    Article  CAS  PubMed  Google Scholar 

  3. Gitto S, Serpi F, Messina C, et al. Bizarre parosteal osteochondromatous proliferation: an educational review. Insights Imaging. 2023;14:109. https://doi.org/10.1186/s13244-023-01455-0.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Bajwa SN, Reddy R, Wagh YS, et al. Bizarre parosteal osteochondromatous proliferation– a case series of typical and atypical presentations. J Orthop Case Rep. 2020;10(1):45–50.

    PubMed Central  Google Scholar 

  5. Torreggiani WC, Munk P, Al-Ismail K, et al. MR imaging features of bizarre parosteal osteochondromatous proliferation of bone (Nora’s lesion). Eur J Radiol. 2001;40:224–31.

    Article  CAS  PubMed  Google Scholar 

  6. Edoardo I, Elisa F, Damiano RA, et al. Bizarre parosteal osteochondromatous proliferation (Nora lesion): a narrative review. Acta Med Litu. 2022;29(2):176–93. https://doi.org/10.15388/Amed.2022.29.2.4.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Samargandi R. unusual site of a bizarre parosteal osteochondromatous proliferation (Nora’s Lesion) involving the scapula: first case report and review of the literature. Cureus. 2023;15(5):e38980. https://doi.org/10.7759/cureus.38980.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Matsui Y, Funakoshi T, Kobayashi H. Bizarre parosteal osteochondromatous proliferation (Nora’s lesion) affecting the distal end of the ulna: a case report. BMC Musculoskelet Disord. 2016;16(17):130. https://doi.org/10.1186/s12891-016-0981-3.

    Article  Google Scholar 

  9. Cocks M, Helmke E, Meyers CA, et al. Bizarre parosteal osteochondromatous proliferation: 16 Cases with a focus on histologic variability. J Orthop. 2018;15(1):138–42. https://doi.org/10.1016/j.jor.2018.01.028.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Mejia-Guerrero S, Quejada M, Gokgoz N, et al. Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma. Genes Chromosomes Cancer. 2010;49(6):518–25. https://doi.org/10.1002/gcc.20761.

    Article  CAS  PubMed  Google Scholar 

  11. Kao YC, Yoshida A, Hsieh TH, et al. Identification of COL1A1/2 Mutations and fusions with noncoding RNA genes in bizarre parosteal osteochondromatous proliferation (Nora lesion). Mod Pathol. 2023;36(2):100011. https://doi.org/10.1016/j.modpat.2022.100011.

    Article  PubMed  Google Scholar 

  12. Dhondt E, Oudenhoven L, Khan S, et al. Nora’s lesion, a distinct radiological entity? Skeletal Radiol. 2006;35:497–502. https://doi.org/10.1007/s00256-005-0041-9.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA

    John Karp & Hamza Alizai

  2. Department of Pathology, University of Pennsylvania, Philadelphia, PA, USA

    Faizan Malik & Paul J. Zhang

  3. Department of Radiology, Children’s Hospital of Pennsylvania, Philadelphia, PA, USA

    Hamza Alizai

Authors
  1. John Karp
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  2. Faizan Malik
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  3. Paul J. Zhang
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  4. Hamza Alizai
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Correspondence to John Karp.

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Karp, J., Malik, F., Zhang, P.J. et al. Bizarre parosteal osteocondromatous proliferation (BPOP) of the acromion with soft tissue recurrence. Skeletal Radiol (2024). https://doi.org/10.1007/s00256-024-04646-y

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  • DOI: https://doi.org/10.1007/s00256-024-04646-y

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