Skip to main content

Advertisement

Log in

Giant cell reparative granuloma of the scapula: report of a case and literature review

  • Case Report
  • Published:
Skeletal Radiology Aims and scope Submit manuscript

A Letter to the Editor to this article was published on 12 November 2019

Abstract

Giant cell reparative granulomas (GCRGs) are non-neoplastic inflammatory lesions, usually observed in the maxilla, mandible or small bones of the hands and feet. These lesions present a wide range of morphology and the misinterpretation with other giant cell lesions can often occur. We report the case of a 47-year-old woman with GCRG in the left scapula, presenting some uncommon features: the location (scapula) and age at presentation, the lack of underlying bone disease such as Paget’s disease or fibrous dysplasia, the large aggressive expansile aspect of the lesion. This was a therapeutic study, level IV (case series with no or a historical control group).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Jaffe HL. Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-osseous) dysplasia of the jawbones. Oral Surg Med Oral Pathol. 1953;6(1):159–75.

    Article  CAS  Google Scholar 

  2. Buirski G, Watt I. The radiographic features of “solid” aneurysmal bone cyst. Br J Radiol. 1984;57(684):1057–65.

    Article  CAS  Google Scholar 

  3. Oda Y, Tsuneyoshi M, Shinohara N. “Solid” variant of aneurysmal bone cyst (extragnathic giant cell reparative granuloma) in the axial skeleton and long bones. A study of its morphologic spectrum and distinction from allied giant cell lesions. Cancer. 1992;70(11):2642–9.

    Article  CAS  Google Scholar 

  4. Athanasou NA, Bansal M, Forsyth R, et al. Giant cell tumour of bone. In: Fletcher CDM, Bridge JA, Hogendoorn PCW, et al., editors. WHO classification of tumours of soft tissue and bone. 4th ed. Lyon: IARC Press; 2013. p. 321–4.

    Google Scholar 

  5. Caskey PM, Wolf MD, Fechner RE. Multicentric giant cell reparative granuloma of the small bones of the hand. Clin Orthop Relat Res. 1985;193:199–205.

    Google Scholar 

  6. Picci P, Baldini N, Sudanese A, Boriani S, Campanacci M. Giant cell reparative granuloma and other giant cell lesions of the bones of the hands and feet. Skeletal Radiol. 1986;15(6):415–21.

    Article  CAS  Google Scholar 

  7. Panico L, Passeretti U, De Rosa N, D’Antonio A, De Rosa G. Giant cell reparative granuloma of the distal skeletal bones. A report of five cases with immunohistochemical findings. Virchows Arch. 1994;425(3):315–20.

    Article  CAS  Google Scholar 

  8. Giza E, Stern PJ, Cualing H. Aggressive giant cell reparative granuloma of the metacarpal: a case report. J Hand Surg. 1997;22(4):732–6.

    Article  CAS  Google Scholar 

  9. Cook KL, Braunstein EM. Computed tomographic appearance of giant cell reparative granuloma of tarsal bone. Comput Med Imaging Graph. 1988;12(2):111–3.

    Article  CAS  Google Scholar 

  10. Ugwonali O, Eisen RN, Wolfe SW. Repair of a multiply recurrent giant cell reparative granuloma of the hand with wide resection and fibular grafting. J Hand Surg Am. 1999;24(6):1331–6.

    Article  CAS  Google Scholar 

  11. Forouhar FA, Phelan NP, Benton DC. Giant cell reparative granuloma of the hands and feet: a report of three cases. Ann Clin Lab Sci. 2000;30(3):272–7.

    CAS  PubMed  Google Scholar 

  12. Macdonald DF, Binhammer PA, Rubenstein JD, Fornasier VL. Giant cell reparative granuloma of the hand: case report and review of giant cell lesion of hand and feet. Can J Surg. 2003;46(6):471–3.

    PubMed  PubMed Central  Google Scholar 

  13. Mavrogenis A, Skarpidi E, Papagelopoulos PJ. Solid variant of aneurysmal bone cyst of the hamate. Musculoskelet Surg. 2010;94(3):145–50.

    Article  Google Scholar 

  14. Kamoun K, Sellami T, Jlailia Z, Abid L, Jenzri M, Bouaziz M, et al. Giant cell reparative granuloma of the hallux following enchondroma. Pan Afr Med J. 2015;22:363.

    Article  Google Scholar 

  15. Huan CM, Norzila AB. Giant cell reparative granuloma mimicking aneurysmal bone cyst in proximal phalanx of toe. Malays Orthop J. 2016;10(1):55–6.

    Article  CAS  Google Scholar 

  16. Robinson D, Hendel D, Halperin N, Levin S. Multicentric giant-cell reparative granuloma. A case in the foot. Acta Orthop Scand. 1989;60(2):232–4.

    Article  CAS  Google Scholar 

  17. Thomas IH, Chow CW, Cole WG. Giant cell reparative granuloma of the humerus. J Pediatr Orthop. 1988;8(5):596–8.

    Article  CAS  Google Scholar 

  18. Hermann G, Abdelwahab IF, Klein MJ, Berson BD, Lewis MM. Case report 603. Giant cell reparative granuloma of the distal end of right femur. Skeletal Radiol. 1990;19(5):367–9.

    CAS  PubMed  Google Scholar 

  19. Subasi M, Kapukaya A, Buyukbayram H, Bukte Y. Giant-cell reparative granuloma of the tibia. Acta Orthop Belg. 2003;69(4):363–7.

    PubMed  Google Scholar 

  20. Ilaslan H, Sundaram M, Unni KK. Solid variant of aneurysmal bone cyst in long tubular bones: giant cell reparative granuloma. AJR Am J Roentgenol. 2003;180(6):1681–7.

    Article  Google Scholar 

  21. Hori T, Kanamori M, Ohmori K, Nobukiyo M, Kimura T. Giant cell reparative granuloma of the proximal tibia: a case report. J Orthop Surg (Hong Kong). 2008;16(3):364–7.

    Article  CAS  Google Scholar 

  22. Inoue H, Tsuneyoshi M, Enjoji M, Shinohara N, Yokoyama K. Giant-cell reparative granuloma of the thoracic vertebra. Acta Pathol Jpn. 1986;36(5):745–50.

    CAS  PubMed  Google Scholar 

  23. Lorenzo JC, Dorfman HD. Giant-cell reparative granuloma of short tubular bones of the hands and feet. Am J Surg Pathol. 1980;4(6):551–63.

    Article  CAS  Google Scholar 

  24. Upchurch KS, Simon LS, Schiller AL, Rosenthal DI, Campion EW, Krane SM. Giant cell reparative granuloma of Paget’s disease of bone: a unique clinical entity. Ann Intern Med. 1983;98(1):35–40.

    Article  CAS  Google Scholar 

  25. Wold LE, Dobyns JH, Swee RG, Dahlin DC. Giant cell reaction (giant cell reparative granuloma) of the small bones of the hands and feet. Am J Surg Pathol. 1986;10(7):491–6.

    Article  CAS  Google Scholar 

  26. De Smet AA, Travers H, Neff JR. Giant cell reparative granuloma of left femur arising in polyostotic fibrous dysplasia. Skeletal Radiol. 1982;8(4):314–8.

    Article  Google Scholar 

  27. Bertoni F, Bacchini P, Capanna R, Ruggieri P, Biagini R, Ferruzzi A, et al. Solid variant of aneurysmal bone cyst. Cancer. 1993;71(3):729–34.

    Article  CAS  Google Scholar 

  28. Maloney WJ, Vaughan LM, Jones HH, Ross J, Nagel DA. Benign metastasizing giant-cell tumor of bone: report of three cases and review of the literature. Clin Orthop Relat Res. 1989;243:208–15.

    Google Scholar 

  29. Ratner V, Dorfman HD. Giant-cell reparative granuloma of the hand and foot bones. Clin Orthop Relat Res. 1990;260:251–8.

    Article  Google Scholar 

  30. Pan Z, Sanger WG, Bridge JA, Hunter WJ, Siegal GP, Wei S. A novel t(6;13)(q15;q34) translocation in a giant cell reparative granuloma (solid aneurysmal bone cyst). Hum Pathol. 2012;43(6):952–7.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

Conception and design of the study (AA, PR).

Acquisition of data (AA, EP, RC).

Analysis and interpretation of data (EP, EB).

Drafting the article or revising it critically for important intellectual content (AA, EP, RC).

Final approval of the version to be submitted (AA, PR).

Corresponding author

Correspondence to Andrea Angelini.

Ethics declarations

Conflicts of interest

Each author certifies that he or she has no commercial associations (e.g., consultancies, stock ownership, equity interest, patent/licensing arrangements) that may pose a conflict of interest in connection with the submitted article.

Ethical review board statement

Each author certifies that his/her institution has approved the reporting of this case and that all investigations were conducted in conformity with ethical principles of research.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Angelini, A., Pagliarini, E., Belluzzi, E. et al. Giant cell reparative granuloma of the scapula: report of a case and literature review. Skeletal Radiol 48, 1293–1298 (2019). https://doi.org/10.1007/s00256-018-3132-0

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00256-018-3132-0

Keywords

Navigation