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Computed tomography-guided percutaneous microwave ablation combined with osteoplasty for palliative treatment of painful extraspinal bone metastases from lung cancer

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Skeletal Radiology Aims and scope Submit manuscript

Abstract

Objective

To retrospectively evaluate the efficacy and safety of microwave ablation (MWA) combined with osteoplasty in lung cancer patients with painful extraspinal bone metastases.

Materials and methods

From January 2011 to July 2014, 26 lung cancer patients with 33 painful extraspinal bone metastases underwent percutaneous MWA combined with osteoplasty. Effectiveness was evaluated by visual analog scale (VAS) and daily morphine dose with a follow-up of 6-months. Complications were also recorded.

Results

Mean VAS score and morphine dose pre-procedure were 7.4 ± 1.6 (range, 5–10) and 47.7 ± 30.1 mg (range, 20–120 mg), respectively. Technical success and pain relief were achieved in all patients. Mean VAS scores and daily morphine doses post-procedure were as follows: 48 h, 1.7 ± 1.2 (p < 0.001) and 29.6 ± 16.1 mg (p = 0.003); 7 days, 1.9 ± 1.7 (p < 0.001) and 16.1 ± 12.0 mg (p < 0.001); 1 month, 1.5 ± 0.9 (p < 0.001) and 10.8 ± 10.9 (p < 0.001); 3 months, 0.9 ± 0.7 (p < 0.001) and 8.4 ± 9.2 mg (p < 0.001); and 6 months, 1.2 ± 0.8 (p < 0.001) and 9.2 ± 12.3 mg (p < 0.001). Complications were observed in eight patients (28 %); among these, major complications were reported in two (7.7 %) patients, one with local infection and the other with a bone fracture. The minor complication rate was 23.1 % (6/26).

Conclusion

MWA combination with osteoplasty appeared to be an effective and safe treatment for lung cancer patients with painful extraspinal bone metastases.

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Conflict of interest

The study was supported by Shandong Province Medical and Health Science and Technology Development projects (2014WS0346).

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    Authors and Affiliations

    1. Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwuweiqi Road, Jinan, Shandong Province, 250021, China

      Zhigang Wei, Xin Ye, Xia Yang, Aimin Zheng, Guanghui Huang & Jiao Wang

    2. Department of Oncology, Teng Zhou Central People’s Hospital Affiliated to Jining Medical College, 181 Xingtan Road, Tengzhou, Shandong Province, 277500, China

      Kaixian Zhang

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    1. Zhigang Wei
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    2. Kaixian Zhang
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    3. Xin Ye
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    4. Xia Yang
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    Correspondence to Xin Ye.

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    Zhigang Wei and Kaixian Zhang contributed equally to this work.

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    Wei, Z., Zhang, K., Ye, X. et al. Computed tomography-guided percutaneous microwave ablation combined with osteoplasty for palliative treatment of painful extraspinal bone metastases from lung cancer. Skeletal Radiol 44, 1485–1490 (2015). https://doi.org/10.1007/s00256-015-2195-4

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    • DOI: https://doi.org/10.1007/s00256-015-2195-4

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