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Imaging of lumbar degenerative disk disease: history and current state

  • Special Issue: Jubilee
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Abstract

One of the most common indications for performing magnetic resonance (MR) imaging of the lumbar spine is the symptom complex thought to originate as a result of degenerative disk disease. MR imaging, which has emerged as perhaps the modality of choice for imaging degenerative disk disease, can readily demonstrate disk pathology, degenerative endplate changes, facet and ligamentous hypertrophic changes, and the sequelae of instability. Its role in terms of predicting natural history of low back pain, identifying causality, or offering prognostic information is unclear. As available modalities for imaging the spine have progressed from radiography, myelography, and computed tomography to MR imaging, there have also been advances in spine surgery for degenerative disk disease. These advances are described in a temporal context for historical purposes with a focus on MR imaging’s history and current state.

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References

  1. Jensen MC, Brant-Zawadzki MN, Obuchowski N, Modic MT, Malkasian D, Ross JS. Magnetic resonance imaging of the lumbar spine in people without back pain. N Engl J Med. 1994;331(2):69–73.

    CAS  PubMed  Google Scholar 

  2. Borenstein DG, O'Mara Jr JW, Boden SD, Lauerman WC, Jacobson A, Platenberg C, et al. The value of magnetic resonance imaging of the lumbar spine to predict low-back pain in asymptomatic subjects: a seven-year follow-up study. J Bone Joint Surg. 2001;83-A(9):1306–11.

    Google Scholar 

  3. Andersson GB. Epidemiological features of chronic low-back pain. Lancet. 1999;354(9178):581–5.

    CAS  PubMed  Google Scholar 

  4. Deyo RA. Early diagnostic evaluation of low back pain. J Gen Intern Med. 1986;1(5):328–38.

    CAS  PubMed  Google Scholar 

  5. Deyo RA, Rainville J, Kent DL. What can the history and physical examination tell us about low back pain? JAMA. 1992;268(6):760–5.

    CAS  PubMed  Google Scholar 

  6. Hart LG, Deyo RA, Cherkin DC. Physician office visits for low back pain. Frequency, clinical evaluation, and treatment patterns from a U.S. national survey. Spine. 1995;20(1):11–9.

    CAS  PubMed  Google Scholar 

  7. Martin BI, Deyo RA, Mirza SK, Turner JA, Comstock BA, Hollingworth W, et al. Expenditures and health status among adults with back and neck problems. JAMA. 2008;299(6):656–64.

    CAS  PubMed  Google Scholar 

  8. Coste J, Delecoeuillerie G, Cohende Lara A, Le Parc JM, Paolaggi JB. Clinical course and prognostic factors in acute low back pain: an inception cohort study in primary care practice. BMJ. 1994;308(6928):577–80.

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Cherkin DC, Deyo RA, Street JH, Barlow W. Predicting poor outcomes for back pain seen in primary care using patients' own criteria. Spine. 1996;21(24):2900–7.

    CAS  PubMed  Google Scholar 

  10. Croft PR, Macfarlane GJ, Papageorgiou AC, Thomas E, Silman AJ. Outcome of low back pain in general practice: a prospective study. BMJ. 1998;316(7141):1356–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Bozzao A, Gallucci M, Masciocchi C, Aprile I, Barile A, Passariello R. Lumbar disk herniation: MR imaging assessment of natural history in patients treated without surgery. Radiology. 1992;185(1):135–41.

    CAS  PubMed  Google Scholar 

  12. Delauche-Cavallier MC, Budet C, Laredo JD, Debie B, Wybier M, Dorfmann H, et al. Lumbar disc herniation. Computed tomography scan changes after conservative treatment of nerve root compression. Spine. 1992;17(8):927–33.

    CAS  PubMed  Google Scholar 

  13. Johnsson KE, Rosen I, Uden A. The natural course of lumbar spinal stenosis. Clin Orthop Relat Res. 1992;279:82–6.

    Google Scholar 

  14. Weiner DK, Kim YS, Bonino P, Wang T. Low back pain in older adults: are we utilizing healthcare resources wisely? Pain Med. 2006;7(2):143–50.

    PubMed  Google Scholar 

  15. Chou R, Qaseem A, Snow V, Casey D, Cross Jr JT, Shekelle P, et al. Diagnosis and treatment of low back pain: a joint clinical practice guideline from the American College of Physicians and the American Pain Society. Ann Intern Med. 2007;147(7):478–91.

    PubMed  Google Scholar 

  16. Modic MT, Ross JS. Lumbar degenerative disk disease. Radiology. 2007;245(1):43–61.

    PubMed  Google Scholar 

  17. Dewing S. Modern radiology in historical perspective. Springfield, IL: Thomas; 1962.

    Google Scholar 

  18. Davis A. Fractures of the spine. J Bone Joint Surg. 1929;11:133–56.

    Google Scholar 

  19. Andrews J. Planigraphy: introduction and history. AJR Am J Roentgenol Am J Roentgenol. 1936;36:575–87.

    Google Scholar 

  20. Jacobeus H. On insufflation of air into the spinal canal for diagnostic purposes in cases of the spinal cord. Acta Med Scand. 1921;21:555–60.

    Google Scholar 

  21. Dandy W. Diagnosis and localization of cord tumors. Ann Surg. 1925;46:463–8.

    Google Scholar 

  22. Sicard JJF. Methode generale d'exploration radiologique par l'huite iodee (Lipidiole). Ann Méd Interne. 1922;46:463–8.

    Google Scholar 

  23. Ramsey G, French J, Strain W. Iodinated organic compounds as contrast media for radiographic diagnoses. IV. Pantopaque myelography. Radiology. 1944;43:236–40.

    Google Scholar 

  24. Peterson HO. The hazards of myelography. Radiology. 1975;115(1):237–9.

    CAS  PubMed  Google Scholar 

  25. Arnell S, Lidstrom F. Myelography with Skiodan (abrodil). Acta Radiol. 1931;12:287–9.

    Google Scholar 

  26. Sackett JF, Strother CM, Quaglieri CE, Javid MJ, Levin AB, Duff TA. Metrizamide–CSF contrast medium. Analysis of clinical application in 215 patients. Radiology. 1977;123(3):779–82.

    CAS  PubMed  Google Scholar 

  27. Eldevik OP, Nakstad P, Kendall BE, Hindmarsh T. Iohexol in lumbar myelography: preliminary results from an open, noncomparative multicenter clinical study. AJNR Am J Neuroradiol Am J Neuroradiol. 1983;4(3):299–301.

    CAS  PubMed  Google Scholar 

  28. Witwer G, Cacayorin ED, Bernstein AD, Hubballah MY, Yuan HA, Kieffer SA. Iopamidol and metrizamide for myelography: prospective double-blind clinical trial. AJR Am J Roentgenol. 1984;143(4):869–73.

    CAS  PubMed  Google Scholar 

  29. Lindblom K. Discography of dissecting transosseous rupture of disks in lumbar region. Acta Radiol. 1951;36:12–6.

    CAS  PubMed  Google Scholar 

  30. Gargano F, Meyer J, Sheldon J. Transfemoral ascending lumbar catheterization of the epidural veins in lumbar disk disease. Radiology. 1974;111:329–36.

    CAS  PubMed  Google Scholar 

  31. Djindjian R. Arteriography of the spinal cord. AJR Am J Roentgenol. 1969;107:461–78.

    CAS  Google Scholar 

  32. Di Chiro G, Schellinger D. Computed tomography of spinal cord after lumbar intrathecal introduction of metrizamide (computer-assisted myelography). Radiology. 1976;120(1):101–4.

    PubMed  Google Scholar 

  33. Knoeller SM, Seifried C. Historical perspective: history of spinal surgery. Spine. 2000;25(21):2838–43.

    CAS  PubMed  Google Scholar 

  34. Kocher T. Die Verletzungen der Wirbelsaule zugleich als Beitrag zur Physiologies des menschlichen Ruckenmarks. Mitt Grenzgeb Med Chir. 1896;1:415–80.

    Google Scholar 

  35. Keller T, Holland MC. Some notable American spine surgeons of the 19th century. Spine. 1997;22(12):1413–7.

    CAS  PubMed  Google Scholar 

  36. Patwardhan RV, Hadley MN. History of surgery for ruptured disk. Neurosurg Clin N Am. 2001;12(1):173–9. x.

    CAS  PubMed  Google Scholar 

  37. Robinson J. Sciatica and the lumbar disk syndrome: a historic perspective. South Med J. 1983;76:232–8.

    CAS  PubMed  Google Scholar 

  38. Schmorl G. Über die pathologische Anatomie der Wirbelbandscheiben. Beitr Klin Chir. 1931;151:360–8.

    Google Scholar 

  39. Dandy W. Loose cartilage from intervertebral disk simulating tumor of the spinal cord. Arch Surg. 1929;19:660–72.

    Google Scholar 

  40. Mixter W, Barr J. Rupture of the intervertebral disc with involvement of the spinal canal. N Engl J Med. 1934;211.

    Google Scholar 

  41. Verbiest H. Results of surgical treatment of idiopathic developmental stenosis of the lumbar vertebral canal. A review of twenty-seven years' experience. J Bone Joint Surg Br. 1977;59(2):181–8.

    CAS  PubMed  Google Scholar 

  42. Harrington PR, Dickson JH. Spinal instrumentation in the treatment of severe progressive spondylolisthesis. Clin Orthop Relat Res. 1976;117:157–63.

    Google Scholar 

  43. Ransohoff J, Spencer F, Siew F, Gage L Jr. Transthoracic removal of thoracic disc. Report of three cases. J Neurosurg. 1969;31(4):459–61.

    CAS  PubMed  Google Scholar 

  44. Harrington PR. The history and development of Harrington instrumentation. Clin Orthop Relat Res. 1973;93:110–2.

    Google Scholar 

  45. Hijikata S. Percutaneous nucleotomy. A new concept technique and 12 years’ experience. Clin Orthop Relat Res. 1989;238:9–23.

    Google Scholar 

  46. Freebody D, Bendall R, Taylor RD. Anterior transperitoneal lumbar fusion. J Bone Joint Surg Br. 1971;53(4):617–27.

    CAS  PubMed  Google Scholar 

  47. Denis F. The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. Spine. 1983;8(8):817–31.

    CAS  PubMed  Google Scholar 

  48. Cotrel Y, Dubousset J, Guillaumat M. New universal instrumentation in spinal surgery. Clin Orthop Relat Res. 1988;227:10–23.

    CAS  PubMed  Google Scholar 

  49. Louis R. Fusion of the lumbar and sacral spine by internal fixation with screw plates. Clin Orthop Relat Res. 1986;203:18–33.

    Google Scholar 

  50. Luque ER. The anatomic basis and development of segmental spinal instrumentation. Spine. 1982;7(3):256–9.

    CAS  PubMed  Google Scholar 

  51. Luque ER. Interpeduncular segmental fixation. Clin Orthop Relat Res. 1986;203:54–7.

    Google Scholar 

  52. Modic MT, Pavlicek W, Weinstein MA, Boumphrey F, Ngo F, Hardy R, et al. Magnetic resonance imaging of intervertebral disk disease. Clinical and pulse sequence considerations. Radiology. 1984;152(1):103–11.

    CAS  PubMed  Google Scholar 

  53. Edelman RR, Shoukimas GM, Stark DD, Davis KR, New PF, Saini S, et al. High-resolution surface-coil imaging of lumbar disk disease. AJR Am J Roentgenol. 1985;144(6):1123–9.

    CAS  PubMed  Google Scholar 

  54. Mansfield P. Multi-planar image formation using NMR spin-echos. J Phys C Solid State Physics. 1977;10:L55–8.

    CAS  Google Scholar 

  55. Haase A, Frahm J, Matthaei D, Hanicke W, Merboldt K. FLASH imaging. Rapid NMR imaging using low flip-angle pulses. J Magn Reson Imaging. 1986;67:258–66.

    CAS  Google Scholar 

  56. Hennig J, Nauerth A, Friedburg H. RARE imaging: a fast imaging method for clinical MR. Magn Reson Med. 1986;3(6):823–33.

    CAS  PubMed  Google Scholar 

  57. Mulkern RV, Wong ST, Winalski C, Jolesz FA. Contrast manipulation and artifact assessment of 2D and 3D RARE sequences. Magn Reson Imaging. 1990;8(5):557–66.

    CAS  PubMed  Google Scholar 

  58. Dwyer AJ, Frank JA, Sank VJ, Reinig JW, Hickey AM, Doppman JL. Short-Ti inversion-recovery pulse sequence: analysis and initial experience in cancer imaging. Radiology. 1988;168(3):827–36.

    CAS  PubMed  Google Scholar 

  59. Ross JS. Newer sequences for spinal MR imaging: smorgasbord or succotash of acronyms? AJNR Am J Neuroradiol. 1999;20(3):361–73.

    CAS  PubMed  PubMed Central  Google Scholar 

  60. Hayes CE, Edelstein WA, Schenck J, Mueller O, Eash M. An efficient, highly homogenous radiofrequency coil for whole-body NMR imaging at 1.5 T. J Magn Reson Imaging. 1985;63:622–8.

    CAS  Google Scholar 

  61. Roemer PB, Edelstein WA, Hayes CE, Souza SP, Mueller OM. The NMR phased array. Magn Reson Med. 1990;16(2):192–225.

    CAS  PubMed  Google Scholar 

  62. Roemer PB, Edelstein WA. Self-shielded gradient coils (abstract). In: Proceedings of the 5th annual conference, Society of Magnetic Resonance in Medicine, Montreal, Quebec, Canada; 1986.

  63. Riederer SJ. MR imaging: its development and the recent Nobel Prize. Radiology. 2004;231(3):628–31.

    PubMed  Google Scholar 

  64. Norman D, Mills CM, Brant-Zawadzki M, Yeates A, Crooks LE, Kaufman L. Magnetic resonance imaging of the spinal cord and canal: potentials and limitations. AJR Am J Roentgenol. 1983;141(6):1147–52.

    CAS  PubMed  Google Scholar 

  65. Maravilla KR, Lesh P, Weinreb JC, Selby DK, Mooney V. Magnetic resonance imaging of the lumbar spine with CT correlation. AJNR Am J Neuroradiol. 1985;6(2):237–45.

    CAS  PubMed  PubMed Central  Google Scholar 

  66. Yu SW, Sether LA, Ho PS, Wagner M, Haughton VM. Tears of the anulus fibrosus: correlation between MR and pathologic findings in cadavers. AJNR Am J Neuroradiol. 1988;9(2):367–70.

    CAS  PubMed  PubMed Central  Google Scholar 

  67. Bergstrom K, Nyberg G, Pech P, Rauschning W, Ytterbergh C. Multiplanar spinal anatomy: comparison of CT and cryomicrotomy in postmortem specimens. AJNR Am J Neuroradiol. 1983;4(3):590–2.

    CAS  PubMed  PubMed Central  Google Scholar 

  68. Nowicki BH, Haughton VM, Schmidt TA, Lim TH, An HS, Riley LH 3rd, et al. Occult lumbar lateral spinal stenosis in neural foramina subjected to physiologic loading. AJNR Am J Neuroradiol. 1996;17(9):1605–14.

    CAS  PubMed  PubMed Central  Google Scholar 

  69. Hueftle MG, Modic MT, Ross JS, Masaryk TJ, Carter JR, Wilber RG, et al. Lumbar spine: postoperative MR imaging with Gd-DTPA. Radiology. 1988;167(3):817–24.

    CAS  PubMed  Google Scholar 

  70. Crisi G, Carpeggiani P, Trevisan C. Gadolinium-enhanced nerve roots in lumbar disk herniation. AJNR Am J Neuroradiol. 1993;14(6):1379–92.

    CAS  PubMed  PubMed Central  Google Scholar 

  71. Lane JI, Koeller KK, Atkinson JL. Enhanced lumbar nerve roots in the spine without prior surgery: radiculitis or radicular veins? AJNR Am J Neuroradiol. 1994;15(7):1317–25.

    CAS  PubMed  PubMed Central  Google Scholar 

  72. Ross JS, Blaser S, Masaryk TJ, Emory SE, Bolesta M, Carter J, et al. Gd-DTPA enhancement of posterior epidural scar: an experimental model. AJNR Am J Neuroradiol. 1989;10(5):1083–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  73. Ross JS, Delamarter R, Hueftle MG, Masaryk TJ, Aikawa M, Carter J, et al. Gadolinium-DTPA-enhanced MR imaging of the postoperative lumbar spine: time course and mechanism of enhancement. AJR Am J Roentgenol. 1989;152(4):825–34.

    CAS  PubMed  Google Scholar 

  74. Ross JS, Masaryk TJ, Schrader M, Gentili A, Bohlman H, Modic MT. MR imaging of the postoperative lumbar spine: assessment with gadopentetate dimeglumine. AJNR Am J Neuroradiol. 1990;11(4):771–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  75. Hiwatashi A, Danielson B, Moritani T, Bakos RS, Rodenhause TG, Pilcher WH, et al. Axial loading during MR imaging can influence treatment decision for symptomatic spinal stenosis. AJNR Am J Neuroradiol. 2004;25(2):170–4.

    PubMed  PubMed Central  Google Scholar 

  76. Maravilla KR, Bowen BC. Imaging of the peripheral nervous system: evaluation of peripheral neuropathy and plexopathy. AJNR Am J Neuroradiol. 1998;19(6):1011–23.

    CAS  PubMed  PubMed Central  Google Scholar 

  77. Antoniou J, Demers CN, Beaudoin G, Goswami T, Mwale F, Aebi M, et al. Apparent diffusion coefficient of intervertebral discs related to matrix composition and integrity. Magn Reson Imaging. 2004;22(7):963–72.

    PubMed  Google Scholar 

  78. Chiu EJ, Newitt DC, Segal MR, Hu SS, Lotz JC, Majumdar S. Magnetic resonance imaging measurement of relaxation and water diffusion in the human lumbar intervertebral disc under compression in vitro. Spine. 2001;26(19):E437–44.

    CAS  PubMed  Google Scholar 

  79. Haughton V. Medical imaging of intervertebral disc degeneration: current status of imaging. Spine. 2004;29(23):2751–6.

    PubMed  Google Scholar 

  80. Hsu EW, Setton LA. Diffusion tensor microscopy of the intervertebral disc anulus fibrosus. Magn Reson Med. 1999;41(5):992–9.

    CAS  PubMed  Google Scholar 

  81. Resnick DK, Niwayama G. Degenerative disease of the spine. Philadelphia, PA: Saunders; 1995.

    Google Scholar 

  82. Nathan H. Osteophytes of the vertebral column: an anatomical study of their development according to age, race, and sex with considerations as to their etiology and significance. J Bone Joint Surg. 1962;44:243–68.

    Google Scholar 

  83. Adams MA, Freeman BJ, Morrison HP, Nelson IW, Dolan P. Mechanical initiation of intervertebral disc degeneration. Spine. 2000;25(13):1625–36.

    CAS  PubMed  Google Scholar 

  84. Hurri H, Karppinen J. Discogenic pain. Pain. 2004;112(3):225–8.

    PubMed  Google Scholar 

  85. Kresina TF, Malemud CJ, Moskowitz RW. Analysis of osteoarthritic cartilage using monoclonal antibodies reactive with rabbit proteoglycan. Arthritis Rheum. 1986;29(7):863–71.

    CAS  PubMed  Google Scholar 

  86. Battie MC, Videman T, Gibbons LE, Fisher LD, Manninen H, Gill K. 1995 Volvo Award in clinical sciences. Determinants of lumbar disc degeneration. A study relating lifetime exposures and magnetic resonance imaging findings in identical twins. Spine. 1995;20(24):2601–12.

    CAS  PubMed  Google Scholar 

  87. Hestbaek L, Iachine IA, Leboeuf-Yde C, Kyvik KO, Manniche C. Heredity of low back pain in a young population: a classical twin study. Twin Res. 2004;7(1):16–26.

    PubMed  Google Scholar 

  88. Majors A, McDevitt C, Sigalis I, Modic MT. A correlative analysis of T2, ADC and MT ratio with water, hydroxyproline and GAG content in excised intervertebral disk. In: Proceedings of the 40th annualmeeting, Orthopaedic Research Society, New Orleans, LA; 1994.

  89. Coventry MB. Anatomy of the intervertebral disk. Clin Orthop Relat Res. 1969;67:9–15.

    CAS  PubMed  Google Scholar 

  90. Friberg S, Hirsch C. Anatomical and clinical studies on lumbar disc degeneration. Acta Orthop Scand. 1949;19(2):222–42. illust.

    CAS  PubMed  Google Scholar 

  91. Hirsch C. Studies on the pathology of low back pain. J Bone Joint Surg Br. 1959;41-B(2):237–43.

    CAS  PubMed  Google Scholar 

  92. Sether LA, Yu S, Haughton VM, Fischer ME. Intervertebral disk: normal age-related changes in MR signal intensity. Radiology. 1990;177(2):385–8.

    CAS  PubMed  Google Scholar 

  93. Yu S, Haughton VM, Sether LA, Ho KC, Wagner M. Criteria for classifying normal and degenerated lumbar intervertebral disks. Radiology. 1989;170(2):523–6.

    CAS  PubMed  Google Scholar 

  94. Knutsson F. The vacuum phenomenon in the intervertebral discs. Acta Radiol. 1942;23:173–9.

    Google Scholar 

  95. Bangert BA, Modic MT, Ross JS, Obuchowski NA, Perl J, Ruggieri PM, et al. Hyperintense disks on T1-weighted MR images: correlation with calcification. Radiology. 1995;195(2):437–43.

    CAS  PubMed  Google Scholar 

  96. Frobin W, Brinckmann P, Kramer M, Hartwig E. Height of lumbar discs measured from radiographs compared with degeneration and height classified from MR images. Eur Radiol. 2001;11(2):263–9.

    CAS  PubMed  Google Scholar 

  97. Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine. 2001;26(17):1873–8.

    CAS  PubMed  Google Scholar 

  98. de Roos A, Kressel H, Spritzer C, Dalinka M. MR imaging of marrow changes adjacent to end plates in degenerative lumbar disk disease. AJR Am J Roentgenol. 1987;149(3):531–4.

    PubMed  Google Scholar 

  99. Modic MT, Steinberg PM, Ross JS, Masaryk TJ, Carter JR. Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology. 1988;166(1 Pt 1):193–9.

    CAS  PubMed  Google Scholar 

  100. Ross JS, Zepp R, Modic MT. The postoperative lumbar spine: enhanced MR evaluation of the intervertebral disk. AJNR Am J Neuroradiol. 1996;17(2):323–31.

    CAS  PubMed  PubMed Central  Google Scholar 

  101. Ross JS, Robertson JT, Frederickson RC, Petrie JL, Obuchowski N, Modic MT, et al. Association between peridural scar and recurrent radicular pain after lumbar discectomy: magnetic resonance evaluation. ADCON-L European Study Group. Neurosurgery. 1996;38(4):855–61, discussion 861–3.

    CAS  PubMed  Google Scholar 

  102. Morrison JL, Kaplan PA, Dussault RG, Anderson MW. Pedicle marrow signal intensity changes in the lumbar spine: a manifestation of facet degenerative joint disease. Skeletal Radiol. 2000;29(12):703–7.

    CAS  PubMed  Google Scholar 

  103. Ulmer JL, Elster AD, Mathews VP, Allen AM. Lumbar spondylolysis: reactive marrow changes seen in adjacent pedicles on MR images. AJR Am J Roentgenol. 1995;164(2):429–33.

    CAS  PubMed  Google Scholar 

  104. Jones A, Clarke A, Freeman BJ, Lam KS, Grevitt MP. The Modic classification: inter- and intraobserver error in clinical practice. Spine. 2005;30(16):1867–9.

    PubMed  Google Scholar 

  105. Schellinger D, Wener L, Ragsdale BD, Patronas NJ. Facet joint disorders and their role in the production of back pain and sciatica. Radiographics. 1987;7(5):923–44.

    CAS  PubMed  Google Scholar 

  106. Doyle AJ, Merrilees M. Synovial cysts of the lumbar facet joints in a symptomatic population: prevalence on magnetic resonance imaging. Spine. 2004;29(8):874–8.

    PubMed  Google Scholar 

  107. Baastrup C. On the spinous processes of the lumbar vertebrae and the soft tissue between them and on pathological changes in that region. Acta Radiol Scan. 1933;14:52–4.

    Google Scholar 

  108. Fardon DF, Milette PC. Nomenclature and classification of lumbar disc pathology. Recommendations of the combined task forces of the North American Spine Society, American Society of Spine Radiology, and American Society of Neuroradiology. Spine. 2001;26(5):E93–113.

    CAS  PubMed  Google Scholar 

  109. Wiltse LL, Berger PE, McCulloch JA. A system for reporting the size and location of lesions in the spine. Spine. 1997;22(13):1534–7.

    CAS  PubMed  Google Scholar 

  110. Jarvik JG, Deyo RA. Diagnostic evaluation of low back pain with emphasis on imaging. Ann Intern Med. 2002;137(7):586–97.

    PubMed  Google Scholar 

  111. Carrino JA, Lurie JD, Tosteson AN, Tosteson TD, Carragee EJ, Kaiser J, et al. Lumbar spine: reliability of MR imaging findings. Radiology. 2009;250(1):161–70.

    PubMed  Google Scholar 

  112. Arana E, Royuela A, Kovacs FM, Estremera A, Sarasibar H, Amengual G, et al. Lumbar spine: agreement in the interpretation of 1.5-T MR images by using the Nordic Modic Consensus Group classification form. Radiology. 254(3):809–17.

    PubMed  Google Scholar 

  113. Lurie JD, Doman DM, Spratt KF, Tosteson AN, Weinstein JN. Magnetic resonance imaging interpretation in patients with symptomatic lumbar spine disc herniations: comparison of clinician and radiologist readings. Spine. 2009;34(7):701–5.

    PubMed  PubMed Central  Google Scholar 

  114. Arnoldi CC, Brodsky AE, Cauchoix J, Crock HV, Dommisse GF, Edgar MA, et al. Lumbar spinal stenosis and nerve root entrapment syndromes. Definition and classification. Clin Orthop Relat Res. 1976;115:4–5.

    Google Scholar 

  115. Amundsen T, Weber H, Lilleas F, Nordal HJ, Abdelnoor M, Magnaes B. Lumbar spinal stenosis. Clinical and radiologic features. Spine. 1995;20(10):1178–86.

    CAS  PubMed  Google Scholar 

  116. Inufusa A, An HS, Lim TH, Hasegawa T, Haughton VM, Nowicki BH. Anatomic changes of the spinal canal and intervertebral foramen associated with flexion-extension movement. Spine. 1996;21(21):2412–20.

    CAS  PubMed  Google Scholar 

  117. Van Goethem JW, Parizel PM, van den Hauwe L, De Schepper AM. Imaging findings in patients with failed back surgery syndrome. J Belge Radiol. 1997;80(2):81–4.

    PubMed  Google Scholar 

  118. Van Goethem JW, Parizel PM, Jinkins JR. Review article: MRI of the postoperative lumbar spine. Neuroradiology. 2002;44(9):723–39.

    PubMed  Google Scholar 

  119. Cervellini P, Curri D, Volpin L, Bernardi L, Pinna V, Benedetti A. Computed tomography of epidural fibrosis after discectomy: a comparison between symptomatic and asymptomatic patients. Neurosurgery. 1988;23(6):710–3.

    CAS  PubMed  Google Scholar 

  120. Coskun E, Suzer T, Topuz O, Zencir M, Pakdemirli E, Tahta K. Relationships between epidural fibrosis, pain, disability, and psychological factors after lumbar disc surgery. Eur Spine J. 2000;9(3):218–23.

    CAS  PubMed  PubMed Central  Google Scholar 

  121. North RB, Campbell JN, James CS, Conover-Walker MK, Wang H, Piantadosi S, et al. Failed back surgery syndrome: 5-year follow-up in 102 patients undergoing repeated operation. Neurosurgery. 1991;28(5):685–90, discussion 690–1.

    CAS  PubMed  Google Scholar 

  122. Hurme M, Katevuo K, Nykvist F, Aalto T, Alaranta H, Einola S. CT five years after myelographic diagnosis of lumbar disk herniation. Acta Radiol. 1991;32(4):286–9.

    CAS  PubMed  Google Scholar 

  123. Olmarker K, Rydevik B. Pathophysiology of sciatica. Orthop Clin North Am. 1991;22(2):223–34.

    CAS  PubMed  Google Scholar 

  124. Sunderland S. Nerves and nerve injuries, 2nd ed. Edinburgh: Churchill Livingstone; 1978.

    Google Scholar 

  125. Van Goethem JW, Van de Kelft E, Biltjes IG, van Hasselt BA, van den Hauwe L, Parizel PM, et al. MRI after successful lumbar discectomy. Neuroradiology. 1996;38 Suppl 1:S90–6.

    PubMed  Google Scholar 

  126. Ross JS, Obuchowski N, Zepp R. The postoperative lumbar spine: evaluation of epidural scar over a 1-year period. AJNR Am J Neuroradiol. 1998;19(1):183–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  127. Lee YS, Choi ES, Song CJ. Symptomatic nerve root changes on contrast-enhanced MR imaging after surgery for lumbar disk herniation. AJNR Am J Neuroradiol. 2009;30(5):1062–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  128. Hitselberger WE, Witten RM. Abnormal myelograms in asymptomatic patients. J Neurosurg. 1968;28(3):204–6.

    CAS  PubMed  Google Scholar 

  129. Wiesel SW, Tsourmas N, Feffer HL, Citrin CM, Patronas N. A study of computer-assisted tomography. I. The incidence of positive CAT scans in an asymptomatic group of patients. Spine. 1984;9(6):549–51.

    CAS  PubMed  Google Scholar 

  130. Boden SD, Davis DO, Dina TS, Patronas NJ, Wiesel SW. Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation. J Bone Joint Surg. 1990;72(3):403–8.

    CAS  PubMed  Google Scholar 

  131. Modic MT, Ross JS, Obuchowski NA, Browning KH, Cianflocco AJ, Mazanec DJ. Contrast-enhanced MR imaging in acute lumbar radiculopathy: a pilot study of the natural history. Radiology. 1995;195(2):429–35.

    CAS  PubMed  Google Scholar 

  132. Saal JA, Saal JS, Herzog RJ. The natural history of lumbar intervertebral disc extrusions treated nonoperatively. Spine. 1990;15(7):683–6.

    CAS  PubMed  Google Scholar 

  133. Modic MT, Obuchowski NA, Ross JS, Brant-Zawadzki MN, Grooff PN, Mazanec DJ, et al. Acute low back pain and radiculopathy: MR imaging findings and their prognostic role and effect on outcome. Radiology. 2005;237(2):597–604.

    PubMed  Google Scholar 

  134. Elfering A, Semmer N, Birkhofer D, Zanetti M, Hodler J, Boos N. Risk factors for lumbar disc degeneration: a 5-year prospective MRI study in asymptomatic individuals. Spine. 2002;27(2):125–34.

    PubMed  Google Scholar 

  135. Carragee EJ, Alamin TF, Miller JL, Carragee JM. Discographic, MRI and psychosocial determinants of low back pain disability and remission: a prospective study in subjects with benign persistent back pain. Spine J. 2005;5(1):24–35.

    PubMed  Google Scholar 

  136. Carragee E, Alamin T, Cheng I, Franklin T, van den Haak E, Hurwitz E. Are first-time episodes of serious LBP associated with new MRI findings? Spine J. 2006;6(6):624–35.

    PubMed  Google Scholar 

  137. Benoist M. The natural history of lumbar degenerative spinal stenosis. Joint Bone Spine. 2002;69(5):450–7.

    PubMed  Google Scholar 

  138. Carragee EJ, Kim DH. A prospective analysis of magnetic resonance imaging findings in patients with sciatica and lumbar disc herniation. Correlation of outcomes with disc fragment and canal morphology. Spine. 1997;22(14):1650–60.

    CAS  PubMed  Google Scholar 

  139. Takada E, Takahashi M, Shimada K. Natural history of lumbar disc hernia with radicular leg pain: spontaneous MRI changes of the herniated mass and correlation with clinical outcome. J Orthop Surg (Hong Kong). 2001;9(1):1–7.

    Google Scholar 

  140. Komori H, Shinomiya K, Nakai O, Yamaura I, Takeda S, Furuya K. The natural history of herniated nucleus pulposus with radiculopathy. Spine. 1996;21(2):225–9.

    CAS  PubMed  Google Scholar 

  141. Yukawa Y, Kato F, Matsubara Y, Kajino G, Nakamura S, Nitta H. Serial magnetic resonance imaging follow-up study of lumbar disc herniation conservatively treated for average 30 months: relation between reduction of herniation and degeneration of disc. J Spinal Disord. 1996;9(3):251–6.

    CAS  PubMed  Google Scholar 

  142. Jensen TS, Albert HB, Sorensen JS, Manniche C, Leboeuf-Yde C. Magnetic resonance imaging findings as predictors of clinical outcome in patients with sciatica receiving active conservative treatment. J Manipulative Physiol Ther. 2007;30(2):98–108.

    PubMed  Google Scholar 

  143. Komori H, Okawa A, Haro H, Shinomiya Ki K. Factors predicting the prognosis of lumbar radiculopathy due to disc herniation. J Orthop Sci. 2002;7(1):56–61.

    PubMed  Google Scholar 

  144. Vroomen PC, Wilmink JT, de KM. Prognostic value of MRI findings in sciatica. Neuroradiology. 2002;44(1):59–63.

    CAS  PubMed  Google Scholar 

  145. Beattie PF, Meyers SP, Stratford P, Millard RW, Hollenberg GM. Associations between patient report of symptoms and anatomic impairment visible on lumbar magnetic resonance imaging. Spine. 2000;25(7):819–28.

    CAS  PubMed  Google Scholar 

  146. Jarvik JJ, Hollingworth W, Heagerty P, Haynor DR, Deyo RA. The Longitudinal Assessment of Imaging and Disability of the Back (LAIDBack) Study: baseline data. Spine. 2001;26(10):1158–66.

    CAS  PubMed  Google Scholar 

  147. Kjaer P, Korsholm L, Bendix T, Sorensen JS, Leboeuf-Yde C. Modic changes and their associations with clinical findings. Eur Spine J. 2006;15(9):1312–9.

    PubMed  PubMed Central  Google Scholar 

  148. Jarvik JG, Hollingworth W, Heagerty PJ, Haynor DR, Boyko EJ, Deyo RA. Three-year incidence of low back pain in an initially asymptomatic cohort: clinical and imaging risk factors. Spine. 2005;30(13):1541–8, discussion 1549.

    PubMed  Google Scholar 

  149. Esposito P, Pinheiro-Franco JL, Froelich S, Maitrot D. Predictive value of MRI vertebral end-plate signal changes (Modic) on outcome of surgically treated degenerative disc disease. Results of a cohort study including 60 patients. Neuro Chirurgie. 2006;52(4):315–22.

    PubMed  Google Scholar 

  150. Vital JM, Gille O, Pointillart V, Pedram M, Bacon P, Razanabola F, et al. Course of Modic 1 six months after lumbar posterior osteosynthesis. Spine. 2003;28(7):715–20, discussion 721.

    CAS  PubMed  Google Scholar 

  151. Chou R, Fu R, Carrino JA, Deyo RA. Imaging strategies for low-back pain: systematic review and meta-analysis. Lancet. 2009;373(9662):463–72.

    PubMed  Google Scholar 

  152. Jarvik JG, Hollingworth W, Martin B, Emerson SS, Gray DT, Overman S, et al. Rapid magnetic resonance imaging vs radiographs for patients with low back pain: a randomized controlled trial. JAMA. 2003;289(21):2810–8.

    PubMed  Google Scholar 

  153. Kerry S, Hilton S, Dundas D, Rink E, Oakeshott P. Radiography for low back pain: a randomised controlled trial and observational study in primary care. Br J Gen Pract. 2002;52(479):469–74.

    PubMed  PubMed Central  Google Scholar 

  154. Lurie JD, Birkmeyer NJ, Weinstein JN. Rates of advanced spinal imaging and spine surgery. Spine. 2003;28(6):616–20.

    PubMed  Google Scholar 

  155. Errico TJ, Fardon DF, Lowell TD. Open discectomy as treatment for herniated nucleus pulposus of the lumbar spine. Spine. 1995;20(16):1829–33.

    CAS  PubMed  Google Scholar 

  156. Keller RB, Atlas SJ, Soule DN, Singer DE, Deyo RA. Relationship between rates and outcomes of operative treatment for lumbar disc herniation and spinal stenosis. J Bone Joint Surg. 1999;81(6):752–62.

    CAS  PubMed  Google Scholar 

  157. Ash LM, Modic MT, Obuchowski NA, Ross JS, Brant-Zawadzki MN, Grooff PN. Effects of diagnostic information, per se, on patient outcomes in acute radiculopathy and low back pain. AJNR Am J Neuroradiol. 2008;29(6):1098–103.

    CAS  PubMed  PubMed Central  Google Scholar 

  158. Gillan MG, Gilbert FJ, Andrew JE, Grant AM, Wardlaw D, Valentine NW, et al. Influence of imaging on clinical decision making in the treatment of lower back pain. Radiology. 2001;220(2):393–9.

    CAS  PubMed  Google Scholar 

  159. Gilbert FJ, Grant AM, Gillan MG, Vale LD, Campbell MK, Scott NW, et al. Low back pain: influence of early MR imaging or CT on treatment and outcome–multicenter randomized trial. Radiology. 2004;231(2):343–51.

    PubMed  Google Scholar 

  160. Wilson IB, Dukes K, Greenfield S, Kaplan S, Hillman B. Patients' role in the use of radiology testing for common office practice complaints. Arch Intern Med. 2001;161(2):256–63.

    CAS  PubMed  Google Scholar 

  161. Verbeek J, Sengers MJ, Riemens L, Haafkens J. Patient expectations of treatment for back pain: a systematic review of qualitative and quantitative studies. Spine. 2004;29(20):2309–18.

    PubMed  Google Scholar 

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Emch, T.M., Modic, M.T. Imaging of lumbar degenerative disk disease: history and current state. Skeletal Radiol 40, 1175–1189 (2011). https://doi.org/10.1007/s00256-011-1163-x

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