Abstract
Drinking water distribution systems (DWDS) are unique engineering environments that are important routes for the acquisition and dissemination of antibiotic resistance. Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in drinking water pose risks to human and environmental health. Metals are known stressors that can select for antibiotic resistance. The objective of this review was to assess the state of knowledge regarding the impact of metal pipe materials, corrosion products, and corrosion inhibitors on the prevalence of antibiotic resistance in DWDS. ARGs and mobile genetic elements (MGEs) have been detected in full-scale DWDS in concentrations ranging from ~ 101 to 1010 copies/L. Metal pipe materials can select for bacteria harboring ARGs and metal resistance genes (MRGs) through co-selection processes. Corrosion products that develop in metal drinking water pipes (Cu, Fe, and Pb oxides) may also stimulate antibiotic resistance selection during distribution. Different corrosion inhibitor regimes (phosphates, sodium silicates) may also have impacts on microbial communities and the abundance of resistance genes in DWDS. Research is needed to quantify how engineering decisions related to drinking water infrastructure and corrosion inhibitor practices impact the abundance and distribution of ARG, MRGs, and MGEs in potable water systems.
Key points
• Lack of quantitative measurements of antibiotic and metal resistance genes in drinking water distribution systems.
• Pipe materials and corrosion products that develop in pipe scales may impact antibiotic resistance.
• Corrosion inhibitors with zinc or phosphate could alter antibiotic resistance.
• Management decisions should consider antibiotic resistance ramifications.
Graphical abstract
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References
Aarestrup FM, Hasman H, Jensen LB, Moreno M, Herrero IA, Domínguez L, Finn M, Franklin A (2002) Antimicrobial resistance among Enterococci from pigs in three European countries. Appl Environ Microbiol 68:4127–4129. https://doi.org/10.1128/AEM.68.8.4127
Aggarwal S, Gomez-Smith CK, Jeon Y, LaPara TM, Waak M, Hozalski RM (2018) Effects of chloramine and coupon material on biofilm abundance and community composition in bench-scale simulated water distribution systems and comparison with full-scale water mains. Environ Sci Technol 52(22):13077–13088. acs.est. 8b02607. https://doi.org/10.1021/acs.est.8b02607
Ahmed E, Holmström SJM (2014) Siderophores in environmental research: roles and applications. Microb Biotechnol 7:196–208. https://doi.org/10.1111/1751-7915.12117
Amarasiri M, Sano D, Suzuki S (2019) Understanding human health risks caused by antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARG) in water environments: current knowledge and questions to be answered. Crit Rev Environ Sci Technol 0:1–44. https://doi.org/10.1080/10643389.2019.1692611
Appenzeller BMR, Duval YB, Thomas F, Block JC (2002) Influence of phosphate on bacterial adhesion onto iron oxyhydroxide in drinking water. Environ Sci Technol 36:646–652. https://doi.org/10.1021/es010155m
Aruoja V, Dubourguier HC, Kasemets K, Kahru A (2009) Toxicity of nanoparticles of CuO, ZnO and TiO2 to microalgae Pseudokirchneriella subcapitata. Sci Total Environ 407:1461–1468. https://doi.org/10.1016/j.scitotenv.2008.10.053
Ashbolt NJ, Amézquita A, Backhaus T, Borriello P, Brandt KK (2013) Review human health risk assessment ( HHRA ) for environmental development and transfer of antibiotic resistance. Environ Health Perspect 121:993–1001
Auerbach EA, Seyfried EE, McMahon KD (2007) Tetracycline resistance genes in activated sludge wastewater treatment plants. Water Res 41:1143–1151. https://doi.org/10.1016/j.watres.2006.11.045
Baker-Austin C, Wright MS, Stepanauskas R, McArthur JV (2006) Co-selection of antibiotic and metal resistance. Trends Microbiol 14:176–182
Balcázar JL, Subirats J, Borrego CM (2015) The role of biofilms as environmental reservoirs of antibiotic resistance. Front Microbiol 6:1–9. https://doi.org/10.3389/fmicb.2015.01216
Batte M, Appenzeller BMR, Grandjean D, Fass S, Gauthier V, Jorand F, Mathieu L, Boualam M, Saby S, Block JC (2003) Biofilms in drinking water distribution systems. Rev Environ Sci Bio/Technol 2:147–168. https://doi.org/10.1023/B:RESB.0000040456.71537.29
Batté M, Mathieu L, Laurent P, Prévost M (2003) Influence of phosphate and disinfection on the composition of biofilms produced from drinking water, as measured by fluorescence in situ hybridization. Can J Microbiol 49:741–753. https://doi.org/10.1139/w03-094
Bédard E, Laferrière C, Déziel E, Prévost M (2018) Impact of stagnation and sampling volume on water microbial quality monitoring in large buildings. PLoS One 13:1–14. https://doi.org/10.1371/journal.pone.0199429
Bergeron S, Boopathy R, Nathaniel R, Corbin A, LaFleur G (2015) Presence of antibiotic resistant bacteria and antibiotic resistance genes in raw source water and treated drinking water. Int Biodeterior Biodegrad 102:370–374. https://doi.org/10.1016/j.ibiod.2015.04.017
Berry D, Xi C, Raskin L (2006) Microbial ecology of drinking water distribution systems. Curr Opin Biotechnol 17:297–302. https://doi.org/10.1016/j.copbio.2006.05.007
Braud A, Hannauer M, Mislin GLA, Schalk IJ (2009) The Pseudomonas aeruginosa pyochelin-iron uptake pathway and its metal specificity. J Bacteriol 191:3517–3525. https://doi.org/10.1128/JB.00010-09
Brown RA, McTigue NE, Cornwell DA (2013) Strategies for assessing optimized corrosion control treatment of lead and copper. J Am Water Works Assoc 105:62–75. https://doi.org/10.5942/jawwa.2013.105.0066
Bruins MR, Kapil S, Oehme FW (2000) Microbial resistance to metals in the environment. Ecotoxicol Environ Saf 45:198–207
Butler G, Ison HCK (1966) Corrosion and its prevention in waters
Cacace D, Fatta-Kassinos D, Manaia CM, Cytryn E, Kreuzinger N, Rizzo L, Karaolia P, Schwartz T, Alexander J, Merlin C, Garelick H, Schmitt H, de Vries D, Schwermer CU, Meric S, Ozkal CB, Pons M-N, Kneis D, Berendonk TU (2019) Antibiotic resistance genes in treated wastewater and in the receiving water bodies: a pan-European survey of urban settings. Water Res 162:320–330. https://doi.org/10.1016/j.watres.2019.06.039
Calomiris JONJ, Armstrong JL, Seidler RJ (1984) Association of metal tolerance with multiple antibiotic resistance of bacteria isolated from drinking water. Appl Environ Microbiol 47:1238–1242
Carey DE, McNamara PJ (2015) The impact of triclosan on the spread of antibiotic resistance in the environment. Front Microbiol 5:1–11. https://doi.org/10.3389/fmicb.2014.00780
Carey DE, Zitomer DH, Hristova KR, Kappell AD, McNamara PJ (2016) Triclocarban influences antibiotic resistance and alters anaerobic digester microbial community structure. Environ Sci Technol 50:126–134. https://doi.org/10.1021/acs.est.5b03080
Cartier C, Nour S, Richer B, Deshommes E, Prévost M (2012) Impact of water treatment on the contribution of faucets to dissolved and particulate lead release at the tap. Water Res 46:5205–5216. https://doi.org/10.1016/j.watres.2012.07.002
Chapman JS (2003) Disinfectant resistance mechanisms, cross-resistance, and co-resistance. Int Biodeterior Biodegrad 51:271–276. https://doi.org/10.1016/S0964-8305(03)00044-1
Chu C, Lu C, Lee C (2005) Effects of inorganic nutrients on the regrowth of heterotrophic bacteria in drinking water distribution systems. J Environ Manag 74:255–263. https://doi.org/10.1016/j.jenvman.2004.09.007
Ciric L, Mullany P, Roberts AP (2011) Antibiotic and antiseptic resistance genes are linked on a novel mobile genetic element: Tn6087. J Antimicrob Chemother 66:2235–2239. https://doi.org/10.1093/jac/dkr311
Courvalin P (1994) Transfer of antibiotic resistance genes between gram-positive and gram-negative bacteria. Antimicrob Agents Chemother 38:1447–1451. https://doi.org/10.1128/AAC.38.7.1447
Crittenden JC, Trussel RR, Hand DW, Howe KJ, Tchobanoglous G (2012) MWH’s water treatment: principles and design, 3rd Editio. John Wiley & Sons Inc.
Cruz MC, Woo Y, Flemming H, Wuertz S (2020) Nitrifying niche differentiation in biofilms from full-scale chloraminated drinking water distribution system. Water Res 176:115738. https://doi.org/10.1016/j.watres.2020.115738
Dai Z, Sevillano-Rivera MC, Calus ST, los Santos QMB, Eren AM, vander Wielen PWJJ, Ijaz UZ, Pinto AJ (2019) Disinfection exhibits systematic impacts on the drinking water microbiome. Microbiome 828970 https://doi.org/10.1101/828970
Di Cesare A, Eckert EM, D’Urso S, Bertoni R, Gillan DC, Wattiez R, Corno G (2016) Co-occurrence of integrase 1, antibiotic and heavy metal resistance genes in municipal wastewater treatment plants. Water Res 94:208–214. https://doi.org/10.1016/j.watres.2016.02.049
Di Cesare A, Eckert EM, Teruggi A, Fontaneto D, Bertoni R, Callieri C, Corno G (2015) Constitutive presence of antibiotic resistance genes within the bacterial community of a large subalpine lake. Mol Ecol 24:3888–3900. https://doi.org/10.1111/mec.13293
Dong P, Wang H, Fang T, Wang Y, Ye Q (2019) Assessment of extracellular antibiotic resistance genes (eARGs) in typical environmental samples and the transforming ability of eARG. Environ Int 125:90–96. https://doi.org/10.1016/j.envint.2019.01.050
Douterelo I, Boxall JB, Deines P, Sekar R, Fish KE, Biggs CA (2014) Methodological approaches for studying the microbial ecology of drinking water distribution systems. Water Res 65:134–156. https://doi.org/10.1016/j.watres.2014.07.008
Douterelo I, Dutilh BE, Arkhipova K, Calero C, Husband S (2020) Microbial diversity, ecological networks and functional traits associated to materials used in drinking water distribution systems. Water Res 173:115586. https://doi.org/10.1016/j.watres.2020.115586
Douterelo I, Husband S, Loza V, Boxall J (2016) Dynamics of biofilm regrowth in drinking water distribution systems. Appl Environ Microbiol 82:4155–4168. https://doi.org/10.1128/AEM.00109-16
Kim EJ, Herrera JE (2010) Characteristics of lead corrosion scales formed during drinking water distribution and their potential influence on the release of lead and other contaminants. Environ Sci Technol 44:6054–6061. https://doi.org/10.1021/es101328u
Edwards M, McNeill LS (2002) Effect of phosphate inhibitors on lead release from pipes. J Am Water Works Assoc 94:79–90. https://doi.org/10.2307/41297947
Falkinham JO (2009) Surrounded by mycobacteria: nontuberculous mycobacteria in the human environment. J Appl Microbiol 107:356–367. https://doi.org/10.1111/j.1365-2672.2009.04161.x
Fang W, Hu JY, Ong SL (2009) Influence of phosphorus on biofilm formation in model drinking water distribution systems. J Appl Microbiol 106:1328–1335. https://doi.org/10.1111/j.1365-2672.2008.04099.x
Feng Y, Teo W-K, Siow K-S, Tan K-L, Hsieh A-K (1996) The corrosion behaviour of copper in neutral tap water. Part I: corrosion mechanisms. Corros Sci 38:369–385. https://doi.org/10.1016/0010-938X(96)00110-2
Flemming HC, Percival SL, Walker JT (2002) Contamination potential of biofilms in water distribution systems. Water Sci Technol Water Supply 2:271–280. https://doi.org/10.1016/S0043-1354(00)00187-1
Gangaiah D, Kassem II, Liu Z, Rajashekara G (2009) Importance of polyphosphate kinase 1 for Campylobacter jejuni viable-but-nonculturable cell formation, natural transformation, and antimicrobial resistance. Appl Environ Microbiol 75:7838–7849. https://doi.org/10.1128/AEM.01603-09
Garner E, Chen C, Xia K, Bowers J, Engelthaler D, McLain J, Edwards MA, Pruden A (2018a) Metagenomic characterization of antibiotic resistance genes in full-scale reclaimed water distribution systems and corresponding potable systems. Environ Sci Technol 44(16):6054–6056. acs.est.7b05419. https://doi.org/10.1021/acs.est.7b05419
Garner E, Inyang M, Garvey E, Parks J, Glover C, Dickenson E, Sutherland J, Salveson A, Edwards MA, Pruden A (2019) Impact of blending for direct potable reuse on premise plumbing microbial ecology and regrowth of opportunistic pathogens and antibiotic resistant bacteria. Water Res 151:75–86. https://doi.org/10.1016/j.watres.2018.12.003
Garner E, Mclain J, Bowers J, Engelthaler DM, Edwards MA, Pruden A (2018b) Microbial ecology and water chemistry impact regrowth of opportunistic pathogens in full-scale reclaimed water distribution systems. Environ Sci Technol. https://doi.org/10.1021/acs.est.8b02818
Gerke TL, Little BJ, Barry Maynard J (2016) Manganese deposition in drinking water distribution systems. Sci Total Environ 541:184–193. https://doi.org/10.1016/j.scitotenv.2015.09.054
Gillings MR, Gaze WH, Pruden A, Smalla K, Tiedje JM, Zhu YG (2015) Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution. ISME J 9:1269–1279. https://doi.org/10.1038/ismej.2014.226
Gomez-Smith CK, Lapara TM, Hozalski RM (2015) Sulfate reducing bacteria and mycobacteria dominate the biofilm communities in a chloraminated drinking water distribution system. Environ Sci Technol 49:8432–8440. https://doi.org/10.1021/acs.est.5b00555
Guo J, Li J, Chen H, Bond PL, Yuan Z (2017) Metagenomic analysis reveals wastewater treatment plants as hotspots of antibiotic resistance genes and mobile genetic elements. Water Res 123:468–478. https://doi.org/10.1016/j.watres.2017.07.002
Guo X, Liu S, Wang Z, Xiang ZX, Li M, Wu B (2014) Metagenomic profiles and antibiotic resistance genes in gut microbiota of mice exposed to arsenic and iron. Chemosphere 112:1–8. https://doi.org/10.1016/j.chemosphere.2014.03.068
Hall RM, Collis CM, Kim MJ, Partridge SR, Recchia GD, Stokes HW (1999) Mobile gene cassettes and integrons in evolution. Ann N Y Acad Sci 870:68–80
Hallam N, West J, Forster C, Simms J (2001) The potential for biofilm growth in water distribution systems. Water Res 35:4063–4071. https://doi.org/10.1016/S0043-1354(01)00248-2
Hannauer M, Braud A, Hoegy F, Ronot P, Boos A, Schalk IJ (2012) The PvdRT-OpmQ efflux pump controls the metal selectivity of the iron uptake pathway mediated by the siderophore pyoverdine in Pseudomonas aeruginosa. Environ Microbiol 14:1696–1708. https://doi.org/10.1111/j.1462-2920.2011.02674.x
Hans M, Erbe A, Mathews S, Chen Y, Solioz M, Mücklich F (2013) Role of copper oxides in contact killing of bacteria. Langmuir 29:16160–16166. https://doi.org/10.1021/la404091z
Hao H, Yang SD, Yang D, Wei YZ, Gang QZ, Li LW, Qiang SZ, Yin J, Ran WH, Wen LJ, Wang H, Jin M (2019) Profiling of intracellular and extracellular antibiotic resistance genes in tap water. J Hazard Mater 365:340–345. https://doi.org/10.1016/j.jhazmat.2018.11.004
Harrison JJ, Tremaroli V, Stan MA, Chan CS, Vacchi-Suzzi C, Heyne BJ, Parsek MR, Ceri H, Turner RJ (2009) Chromosomal antioxidant genes have metal ion-specific roles as determinants of bacterial metal tolerance. Environ Microbiol 11:2491–2509
Harrison KR, Kappell AD, McNamara PJ (2020) Benzalkonium chloride alters phenotypic and genotypic antibiotic resistance profiles in a source water used for drinking water treatment. Environ Pollut 257:113472. https://doi.org/10.1016/j.envpol.2019.113472
Hartmann EM, Hickey R, Hsu T, Betancourt Román CM, Chen J, Schwager R, Kline J, Brown GZ, Halden RU, Huttenhower C, Green JL (2016) Antimicrobial chemicals are associated with elevated antibiotic resistance genes in the indoor dust microbiome. Environ Sci Technol 50:9807–9815. https://doi.org/10.1021/acs.est.6b00262
Hasman H, Aarestrup FM (2005) Relationship between copper , glycopeptide , and macrolide resistance among Enterococcus faecium strains isolated from pigs in Denmark between 1997 and 2003. Antimicrob Agents Chemother 49:2003–2006. https://doi.org/10.1128/AAC.49.1.454
Hasman H, Aarestrup FM (2002) tcrb, a gene conferring transferable copper resistance in Enterococcus faecium: occurrence, transferability, and linkage to macrolide and glycopeptide resistance. Antimicrob Agents Chemother 46:1410–1416. https://doi.org/10.1128/AAC.46.5.1410-1416.2002
Huang H, Zeng S, Dong X, Li D, Zhang Y, He M, Du P (2019) Diverse and abundant antibiotics and antibiotic resistance genes in an urban water system. J Environ Manag 231:494–503. https://doi.org/10.1016/j.jenvman.2018.10.051
Jang HJ, Choi YJ, Ro HM, Ka JO (2012) Effects of phosphate addition on biofilm bacterial communities and water quality in annular reactors equipped with stainless steel and ductile cast iron pipes. J Microbiol 50:17–28. https://doi.org/10.1007/s12275-012-1040-x
Ji P, Parks J, Edwards MA, Pruden A (2015) Impact of water chemistry, pipe material and stagnation on the building plumbing microbiome. PLoS One 10:1–23. https://doi.org/10.1371/journal.pone.0141087
Ju F, Li B, Ma L, Wang Y, Huang D, Zhang T (2016) Antibiotic resistance genes and human bacterial pathogens: co-occurrence, removal, and enrichment in municipal sewage sludge digesters. Water Res 91:1–10. https://doi.org/10.1016/j.watres.2015.11.071
Kang YC, Ooij WJ Van Lytle DA (2008) Characterization of copper corrosion products formed in drinking water by combining electrochemical and surface analyses. Corrosion 3346–3364
Kappell AD, De Nies MS, Ahuja NH, Ledeboer NA, Newton RJ, Hristova KR (2015) Detection of multi-drug resistant Escherichia coli in the urban waterways of Milwaukee, WI. Front Microbiol 6:1–12. https://doi.org/10.3389/fmicb.2015.00336
Kappell AD, Harrison KR, McNamara PJ (2019) Effects of zinc orthophosphate on the antibiotic resistant bacterial community of a source water used for drinking water treatment. Environ Sci Water Res Technol. https://doi.org/10.1039/C9EW00374F
Kappell AD, Kimbell LK, Seib MD, Carey DE, Choi MJ, Kalayil T, Fujimoto M, Zitomer DH, McNamara PJ (2018) Removal of antibiotic resistance genes in an anaerobic membrane bioreactor treating primary clarifier effluent at 20 °C. Environ Sci Water Res Technol 4:1783–1793. https://doi.org/10.1039/C8EW00270C
Kimbell LK, Kappell AD, McNamara PJ (2018) Effect of pyrolysis on the removal of antibiotic resistance genes and class I integrons from municipal wastewater biosolids. Environ Sci Water Res Technol 4:1807–1818. https://doi.org/10.1039/C8EW00141C
Knapp CW, Callan AC, Aitken B, Shearn R, Koenders A, Hinwood A (2017) Relationship between antibiotic resistance genes and metals in residential soil samples from Western Australia. Environ Sci Pollut Res 24:2484–2494. https://doi.org/10.1007/s11356-016-7997-y
Knapp CW, McCluskey SM, Singh BK, Campbell CD, Hudson G, Graham DW (2011) Antibiotic resistance gene abundances correlate with metal and geochemical conditions in archived Scottish soils. PLoS One 6:e27300. https://doi.org/10.1371/journal.pone.0027300
Kogo A, Payne SJ, Andrews RC (2017) Impact of corrosion control on biofilm development in simulated partial lead service line replacements. Environ Eng Sci 34:711–720. https://doi.org/10.1089/ees.2016.0507
Koike S, Krapac IG, Oliver HD, Yannarell AC, Chee-Sanford JC, Aminov RI, Mackie RI (2007) Monitoring and source tracking of tetracycline resistance genes in lagoons and groundwater adjacent to swine production facilities over a 3-year period. Appl Environ Microbiol 73:4813–4823. https://doi.org/10.1128/AEM.00665-07
Kusnetsov J, Iivanainen E, Elomaa N, Zacheus O, Martikainen PJ (2001) Copper and silver ions more effective against Legionellae than against mycobacteria in a hospital warm water system. Water Res 35:4217–4225. https://doi.org/10.1016/S0043-1354(01)00124-5
Lane RW, Larson TE, Schilsky SW (1977) Effect of pH on the silicate treatment of hot water in galvanized piping. J Am Water Works Assoc 69:457–461. https://doi.org/10.1002/j.1551-8833.1977.tb06789.x
LaPara TM, Burch TR, McNamara PJ, Tan DT, Yan M, Eichmiller JJ (2011) Tertiary-treated municipal wastewater is a significant point source of antibiotic resistance genes into Duluth-Superior Harbor. Environ Sci Technol 45:9543–9549. https://doi.org/10.1021/es202775r
Lautenschlager K, Boon N, Wang Y, Egli T, Hammes F (2010) Overnight stagnation of drinking water in household taps induces microbial growth and changes in community composition. Water Res 44:4868–4877. https://doi.org/10.1016/j.watres.2010.07.032
LeChevallier M, Besner M, Friedman M, Speight V (2011) Microbial quality control in distribution systems. In: Water Quality and Treatment: A Handbook of Drinking Water
Lehtola MJ, Laxander M, Miettinen IT, Hirvonen A, Vartiainen T, Martikainen PJ (2006) The effects of changing water flow velocity on the formation of biofilms and water quality in pilot distribution system consisting of copper or polyethylene pipes. Water Res 40:2151–2160. https://doi.org/10.1016/j.watres.2006.04.010
Lehtola MJ, Miettinen IT, Lampola T, Hirvonen A, Vartiainen T, Martikainen PJ (2005) Pipeline materials modify the effectiveness of disinfectants in drinking water distribution systems. Water Res 39:1962–1971. https://doi.org/10.1016/j.watres.2005.03.009
Lehtola MJ, Miettinen IT, Martikainen PJ (2002) Biofilm formation in drinking water affected by low concentrations of phosphorus. Can J Microbiol 48:494–499. https://doi.org/10.1139/w02-048
Lemire JA, Harrison JJ, Turner RJ (2013) Antimicrobial activity of metals: mechanisms, molecular targets and applications. Nat Rev Microbiol 11:371–384. https://doi.org/10.1038/nrmicro3028
Levy SB, Fitzgerald GB, Macone AB (1976) Spread of antibiotic-resistant plasmids from chicken to chicken and from chicken to man. Nature 260:40–42. https://doi.org/10.1038/260040a0
Li X, Wang H, Hu C, Yang M, Hu H, Niu J (2015) Characteristics of biofilms and iron corrosion scales with ground and surface waters in drinking water distribution systems. Corros Sci 90:331–339. https://doi.org/10.1016/j.corsci.2014.10.028
Lin W, Yu Z, Zhang H, Thompson IP (2014) Diversity and dynamics of microbial communities at each step of treatment plant for potable water generation. Water Res 52:218–230. https://doi.org/10.1016/j.watres.2013.10.071
Ling F, Whitaker R, LeChevallier MW, Liu WT (2018) Drinking water microbiome assembly induced by water stagnation. ISME J 12:1520–1531, 1–12. https://doi.org/10.1038/s41396-018-0101-5
Lintereur PA, Duranceau SJ, Taylor JS, Stone ED (2010) Sodium silicate impacts on lead release in a blended potable water distribution system. Desalin Water Treat 16:427–438. https://doi.org/10.5004/dwt.2010.1477
Liu G, Bakker GL, Li S, Vreeburg JHG, Verberk JQJC, Medema GJ, Liu WT, Van Dijk JC (2014) Pyrosequencing reveals bacterial communities in unchlorinated drinking water distribution system: an integral study of bulk water, suspended solids, loose deposits, and pipe wall biofilm. Environ Sci Technol 48:5467–5476. https://doi.org/10.1021/es5009467
Liu S, Gunawan C, Barraud N, Rice SA, Harry EJ, Amal R (2016) Understanding, monitoring, and controlling biofilm growth in drinking water distribution systems. Environ Sci Technol 50:8954–8976. https://doi.org/10.1021/acs.est.6b00835
Liu Z, Stout JE, Tedesco L, Boldin M, Hwang C, Diven WF, Yu VL (1994) Controlled evaluation of copper-silver ionization in eradicating Legionella pneumophila from a hospital water distribution system. J Infect Dis 169:919–922
Lytle DA, Nadagouda MN (2010) A comprehensive investigation of copper pitting corrosion in a drinking water distribution system. Corros Sci 52:1927–1938. https://doi.org/10.1016/j.corsci.2010.02.013
Lytle DA, Schock MR (2005) Formation of Pb (IV) oxides in chlorinated water. J Am Water Works Assoc 97:102–114. https://doi.org/10.2307/41313634
Lytle DA, Sorg TJ, Frietch C (2004) Accumulation of arsenic in drinking water distribution systems. Environ Sci Technol 38:5365–5372. https://doi.org/10.1021/es049850v
Ma L, Li AD, Le Yin X, Zhang T (2017a) The prevalence of integrons as the carrier of antibiotic resistance genes in natural and man-made environments. Environ Sci Technol 51:5721–5728. https://doi.org/10.1021/acs.est.6b05887
Ma L, Li B, Zhang T (2019) New insights into antibiotic resistome in drinking water and management perspectives: a metagenomic based study of small-sized microbes. Water Res 152:191–201. https://doi.org/10.1016/j.watres.2018.12.069
Ma X, Vikram A, Casson L, Bibby K (2017b) Centralized drinking water treatment operations shape bacterial and fungal community structure. Environ Sci Technol 51:7648–7657. https://doi.org/10.1021/acs.est.7b00768
Ma Y, Wilson CA, Novak JT, Riffat R, Aynur S, Murthy S, Pruden A (2011) Effect of various sludge digestion conditions on sulfonamide, macrolide, and tetracycline resistance genes and class I integrons. Environ Sci Technol 45:7855–7861. https://doi.org/10.1021/es200827t
Mackie RI, Koike S, Krapac I, Chee-Sanford J, Maxwell S, Aminov RI (2006) Tetracycline residues and tetracycline resistance genes in groundwater impacted by swine production facilities. Anim Biotechnol 17:157–176. https://doi.org/10.1080/10495390600956953
Manuel CM, Nunes OC, Melo LF (2007) Dynamics of drinking water biofilm in flow/non-flow conditions. Water Res 41:551–562. https://doi.org/10.1016/j.watres.2006.11.007
Mao D, Yu S, Rysz M, Luo Y, Yang F, Li F, Hou J, Mu Q, Alvarez PJJ (2015) Prevalence and proliferation of antibiotic resistance genes in two municipal wastewater treatment plants. Water Res 85:458–466. https://doi.org/10.1016/j.watres.2015.09.010
Martinez JL, Sánchez MB, Martínez-Solano L, Hernandez A, Garmendia L, Fajardo A, Alvarez-Ortega C (2009) Functional role of bacterial multidrug efflux pumps in microbial natural ecosystems. FEMS Microbiol Rev 33:430–449. https://doi.org/10.1111/j.1574-6976.2008.00157.x
McNeill L, Edwards M (2002) Phosphate inhibitor use at US utilities. J Am Water Works Assoc 94:57–63
McNeill LS, Edwards M (2001) Iron pipe corrosion in distribution systems. J Am Water Works Assoc 93:88–100. https://doi.org/10.1002/j.1551-8833.2001.tb09246.x
McNeill LS, Edwards M (2004) Importance of Pb and Cu particulate species for corrosion control. J Environ Eng 130:136–144. https://doi.org/10.1061/(asce)0733-9372(2004)130:2(136)
Morvay AA, Decun M, Scurtu M, Sala C, Morar A, Sarandan M (2011) Biofilm formation on materials commonly used in household drinking water systems. Water Sci Technol Water Supply 11:252–257. https://doi.org/10.2166/ws.2011.053
Munir M, Xagoraraki I (2011) Levels of antibiotic resistance genes in manure, biosolids, and fertilized soil. J Environ Qual 40:248. https://doi.org/10.2134/jeq2010.0209
Neu L, Proctor CR, Walser J, Hammes F (2019) Small-scale heterogeneity in drinking water biofilms. Front Microbiol 10:1–14. https://doi.org/10.3389/fmicb.2019.02446
Nguyen C, Elfland C, Edwards M (2012) Impact of advanced water conservation features and new copper pipe on rapid chloramine decay and microbial regrowth. Water Res 46:611–621. https://doi.org/10.1016/j.watres.2011.11.006
Niquette P, Servais P, Savoir R (2000) Impacts of pipe materials on densities of fixed bacterial biomass in a drinking water distribution system. Water Res 34:1952–1956. https://doi.org/10.1016/S0043-1354(99)00307-3
Noel JD, Wang Y, Giammar DE (2014) Effect of water chemistry on the dissolution rate ofthe lead corrosion product hydrocerussite. Water Res 54:237–246. https://doi.org/10.1016/j.watres.2014.02.004
Oh S, Hammes F, Liu WT (2018) Metagenomic characterization of biofilter microbial communities in a full-scale drinking water treatment plant. Water Res 128:278–285. https://doi.org/10.1016/j.watres.2017.10.054
Outten FW, Huffman DL, Hale JA, O’Halloran TV (2001) The independent cue and cus systems confer copper tolerance during aerobic and anaerobic growth in Escherichia coli. J Biol Chem 276:30670–30677. https://doi.org/10.1074/jbc.M104122200
Pal C, Asiani K, Arya S, Rensing C, Stekel DJ, Larsson DGJ, Hobman JL (2017) Metal resistance and its association with antibiotic resistance. Adv Microb Physiol 70:261–313. https://doi.org/10.1016/bs.ampbs.2017.02.001
Pal C, Bengtsson-Palme J, Kristiansson E, Larsson DGJ (2015) Co-occurrence of resistance genes to antibiotics, biocides and metals reveals novel insights into their co-selection potential. BMC Genomics 16:1–14. https://doi.org/10.1186/s12864-015-2153-5
Pal C, Bengtsson-Palme J, Rensing C, Kristiansson E, Larsson DGJ (2014) BacMet: antibacterial biocide and metal resistance genes database. Nucleic Acids Res 42:737–743. https://doi.org/10.1093/nar/gkt1252
Pang H, Gao F, Lu Q (2009) Morphology effect on antibacterial activity of cuprous oxide. Chem Commun:1076–1078. https://doi.org/10.1039/b816670f
Payne SJ, Piorkowski GS, Hansen LT, Gagnon GA (2016) Impact of zinc orthophosphate on simulated drinking water biofilms influenced by lead and copper. J Environ Eng 142:1136–1144. https://doi.org/10.1061/(ASCE)EE
Peltier E, Vincent J, Finn C, Graham DW (2010) Zinc-induced antibiotic resistance in activated sludge bioreactors. Water Res 44:3829–3836. https://doi.org/10.1016/j.watres.2010.04.041
Peng CY, Hill AS, Friedman MJ, Valentine RL, Larson GS, Romero AMY, Reiber SH, Korshin GV (2012) Occurrence of trace inorganic contaminants in drinking water distribution systems. J Am Water Works Assoc 104:53–54. https://doi.org/10.5942/jawwa.2012.104.0042
Peng CY, Korshin GV (2011) Speciation of trace inorganic contaminants in corrosion scales and deposits formed in drinking water distribution systems. Water Res 45:5553–5563. https://doi.org/10.1016/j.watres.2011.08.017
Peng CY, Korshin GV, Valentine RL, Hill AS, Friedman MJ, Reiber SH (2010) Characterization of elemental and structural composition of corrosion scales and deposits formed in drinking water distribution systems. Water Res 44:4570–4580. https://doi.org/10.1016/j.watres.2010.05.043
Pinto A, Schroeder J, Lunn M, Sloan W, Raskin L (2014) Spatial-temporal survey and occupancy-abundance modeling to predict bacterial community dynamics in the drinking water microbiome. MBio 5:1–13. https://doi.org/10.1128/mBio.01135-14.Editor
Pinto AJ, Xi C, Raskin L (2012) Bacterial community structure in the drinking water microbiome is governed by filtration processes. Environ Sci Technol. https://doi.org/10.1021/es302042t
Poole K (2017) At the nexus of antibiotics and metals: the impact of Cu and Zn on antibiotic activity and resistance. Trends Microbiol 25:820–832. https://doi.org/10.1016/j.tim.2017.04.010
Potgieter S, Pinto A, Sigudu M, du Preez H, Ncube E, Venter S (2018) Long-term spatial and temporal microbial community dynamics in a large-scale drinking water distribution system with multiple disinfectant regimes. Water Res 139:406–419. https://doi.org/10.1016/j.watres.2018.03.077
Prest EI, Weissbrodt DG, Hammes F, Van Loosdrecht MCM, Vrouwenvelder JS (2016) Long-term bacterial dynamics in a full-scale drinking water distribution system. PLoS One 11:1–20. https://doi.org/10.1371/journal.pone.0164445
Proctor CR, Dai D, Edwards MA, Pruden A (2017) Interactive effects of temperature, organic carbon, and pipe material on microbiota composition and Legionella pneumophila in hot water plumbing systems. Microbiome 5:130. https://doi.org/10.1186/s40168-017-0348-5
Proctor CR, Hammes F (2015) Drinking water microbiology-from measurement to management. Curr Opin Biotechnol 33:87–94. https://doi.org/10.1016/j.copbio.2014.12.014
Pruden A, Alcalde RE, Alvarez PJJ, Ashbolt N, Bischel H, Capiro NL, Crossette E, Frigon D, Grimes K, Haas CN, Ikuma K, Kappell A, LaPara T, Kimbell L, Li M, Li X, McNamara P, Seo Y, Sobsey MD, Sozzi E, Navab-Daneshmand T, Raskin L, Riquelme MV, Vikesland P, Wigginton K, Zhou Z (2018) An environmental science and engineering framework for combating antimicrobial resistance. Environ Eng Sci 35:ees.2017.0520. https://doi.org/10.1089/ees.2017.0520
Pruden A, Arabi M, Storteboom HN (2012) Correlation between upstream human activities and riverine antibiotic resistance genes. Environ Sci Technol 46:11541–11549. https://doi.org/10.1021/es302657r
Pruden A, Pei R, Storteboom H, Carlson KH (2006) Antibiotic resistance genes as emerging contaminants: studies in northern Colorado. Environ Sci Technol 40:7445–7450. https://doi.org/10.1021/es060413l
Rao NN, Kornberg A (1996) Inorganic polyphosphate supports resistance and survival of stationary-phase Escherichia coli. J Bacteriol 178:1394–1400. https://doi.org/10.1128/jb.178.5.1394-1400.1996
Rensing C, Grass G (2003) Escherichia coli mechanisms of copper homeostasis in a changing environment. FEMS Microbiol Rev 27:197–213. https://doi.org/10.1016/S0168-6445(03)00049-4
Rhoads WJ, Pruden A, Edwards MA (2017) Interactive effects of corrosion, copper, and chloramines on Legionella and Mycobacteria in hot water plumbing. Environ Sci Technol 51:7065–7075. https://doi.org/10.1021/acs.est.6b05616
Rice EW, Wang P, Smith AL, Stadler LB (2020) Determining hosts of antibiotic resistance genes: a review of methodological advances. Environ Sci Technol Lett. https://doi.org/10.1021/acs.estlett.0c00202
Rocha J, Fernandes T, Riquelme MV, Zhu N, Pruden A, Manaia CM (2019) Comparison of culture-and quantitative PCR-based indicators of antibiotic resistance in wastewater, recycled water, and tap water. Int J Environ Res Public Health 16:4217. https://doi.org/10.3390/ijerph16214217
Rompré A, Prévost M, Coallier J, Brisebois P, Lavoie J (2000) Impacts of implementing a corrosion control strategy on biofilm growth. Water Sci Technol 41:287–294. https://doi.org/10.2166/wst.2000.0457
Rożej A, Cydzik-Kwiatkowska A, Kowalska B, Kowalski D (2015) Structure and microbial diversity of biofilms on different pipe materials of a model drinking water distribution systems. World J Microbiol Biotechnol 31:37–47. https://doi.org/10.1007/s11274-014-1761-6
Sakcham B, Kumar A, Cao B (2019) Extracellular DNA in monochloraminated drinking water and its influence on DNA-based profiling of microbial community. Environ Sci Technol Lett 6:306–312. acs.estlett.9b00185. https://doi.org/10.1021/acs.estlett.9b00185
Sanganyado E, Gwenzi W (2019) Antibiotic resistance in drinking water systems: occurrence, removal, and human health risks. Sci Total Environ 669:785–797. https://doi.org/10.1016/j.scitotenv.2019.03.162
Sarin P, Snoeyink VL, Bebee J, Jim KK, Beckett MA, Kriven WM, Clement JA (2004) Iron release from corroded iron pipes in drinking water distribution systems: effect of dissolved oxygen. Water Res 38:1259–1269. https://doi.org/10.1016/j.watres.2003.11.022
Sarin P, Snoeyink VL, Bebee J, Kriven WM, Clement JA (2001) Physico-chemical characteristics of corrosion scales in old iron pipes. Water Res 35:2961–2969
Schock MR, Hyland RN, Welch MM (2008) Occurrence of contaminant accumulation in lead pipe scales from domestic drinking-water distribution systems. Environ Sci Technol 42:4285–4291. https://doi.org/10.1021/es702488v
Schock MR, Lytle DA, Sandvig AM, Clement J, Harmon SM (2005a) Replacing polyphosphate with silicate to solve lead, copper, and source water iron problems. J Am Water Works Assoc 97:84–93. https://doi.org/10.1002/j.1551-8833.2005.tb07521.x
Schock MR, Scheckel KG, Desantis MK, Gerke T (2005b) Mode of occurrence, treatment, and monitoring significance of tetravalent lead. 2005 Water Qual Technol Conf Proceedings, WQTC 2005
Seiler C, Berendonk TU (2012) Heavy metal driven co-selection of antibiotic resistance in soil and water bodies impacted by agriculture and aquaculture. Front Microbiol 3:399. https://doi.org/10.3389/fmicb.2012.00399
Sharma VK, Johnson N, Cizmas L, McDonald TJ, Kim H (2016) A review of the influence of treatment strategies on antibiotic resistant bacteria and antibiotic resistance genes. Chemosphere 150:702–714. https://doi.org/10.1016/j.chemosphere.2015.12.084
Shen Y, Huang C, Lin J, Wu W, Ashbolt NJ, Liu WT, Nguyen TH (2017) Effect of disinfectant exposure on Legionella pneumophila associated with simulated drinking water biofilms: release, inactivation, and infectivity. Environ Sci Technol 51:2087–2095. https://doi.org/10.1021/acs.est.6b04754
Shen Y, Huang PC, Huang C, Sun P, Monroy GL, Wu W, Lin J, Espinosa-Marzal RM, Boppart SA, Liu WT, Nguyen TH (2018) Effect of divalent ions and a polyphosphate on composition, structure, and stiffness of simulated drinking water biofilms. Npj Biofilms Microbiomes 4:1–9. https://doi.org/10.1038/s41522-018-0058-1
Song J, Rensing C, Holm PE, Virta M, Brandt KK (2017) Comparison of metals and tetracycline as selective agents for development of tetracycline resistant bacterial communities in agricultural soil. Environ Sci Technol 51:3040–3047. https://doi.org/10.1021/acs.est.6b05342
Stepanauskas R, Glenn TC, Jagoe CH, Tuckfield RC, Lindell AH, McArthur JV (2005) Elevated microbial tolerance to metals and antibiotics in metal-contaminated industrial environments. Environ Sci Technol 39:3671–3678. https://doi.org/10.1021/es048468f
Su HC, Liu YS, Pan CG, Chen J, He LY, Ying GG (2018) Persistence of antibiotic resistance genes and bacterial community changes in drinking water treatment system: from drinking water source to tap water. Sci Total Environ 616–617:453–461. https://doi.org/10.1016/j.scitotenv.2017.10.318
Sun H, Shi B, Bai Y, Wang D (2014a) Bacterial community of biofilms developed under different water supply conditions in a distribution system. Sci Total Environ 472:99–107. https://doi.org/10.1016/j.scitotenv.2013.11.017
Sun H, Shi B, Lytle DA, Bai Y, Wang D (2014b) Formation and release behavior of iron corrosion products under the influence of bacterial communities in a simulated water distribution system. Environ Sci Process Impacts 16:576–585. https://doi.org/10.1039/c3em00544e
Sun H, Shi B, Yang F, Wang D (2017) Effects of sulfate on heavy metal release from iron corrosion scales in drinking water distribution system. Water Res 114:69–77. https://doi.org/10.1016/j.watres.2017.02.021
Szekeres E, Chiriac CM, Baricz A, Szőke-Nagy T, Lung I, Soran ML, Rudi K, Dragos N, Coman C (2018) Investigating antibiotics, antibiotic resistance genes, and microbial contaminants in groundwater in relation to the proximity of urban areas. Environ Pollut 236:734–744. https://doi.org/10.1016/j.envpol.2018.01.107
Van Der Kooij D, Veenendaal HR, Scheffer WJH (2005) Biofilm formation and multiplication of Legionella in a model warm water system with pipes of copper, stainless steel and cross-linked polyethylene. Water Res 39:2789–2798. https://doi.org/10.1016/j.watres.2005.04.075
Van Hoek AHAM, Mevius D, Guerra B, Mullany P, Roberts AP, Aarts HJM (2011) Acquired antibiotic resistance genes: An overview. Front Microbiol 2:203
Vikesland PJ, Pruden A, Alvarez PJJ, Aga D, Bürgmann H, Li XD, Manaia CM, Nambi I, Wigginton K, Zhang T, Zhu YG (2017) Toward a comprehensive strategy to mitigate dissemination of environmental sources of antibiotic resistance. Environ Sci Technol 51:13061–13069. https://doi.org/10.1021/acs.est.7b03623
Volk C, Dundore E, Schiermann J, Lechevallier M (2000) Practical evaluation of iron corrosion control in a drinking water distribution system. Water Res 34:1967–1974. https://doi.org/10.1016/S0043-1354(99)00342-5
Waak MB, Hozalski RM, Hallé C, Lapara TM (2019) Comparison of the microbiomes of two drinking water distribution systems - with and without residual chloramine disinfection. Microbiome 7:1–14. https://doi.org/10.1186/s40168-019-0707-5
Wang H, Masters S, Edwards MA, Falkinham JO, Pruden A (2014) Effect of disinfectant, water age, and pipe materials on bacterial and eukaryotic community structure in drinking water biofilm. Environ Sci Technol 48:1426–1435. https://doi.org/10.1021/es402636u
Wang H, Masters S, Hong Y, Stallings J, Falkinham JO, Edwards MA, Pruden A (2012) Effect of disinfectant, water age, and pipe material on occurrence and persistence of Legionella, mycobacteria, Pseudomonas aeruginosa, and two amoebas. Environ Sci Technol 46:11566–11574. https://doi.org/10.1021/es303212a
Waseem H, Jameel S, Ali J, Ur Rehman HS, Tauseef I, Farooq U, Jamal A, Ali MI (2019) Contributions and challenges of high throughput qPCR for determining antimicrobial resistance in the environment: a critical review. Molecules 24:163. https://doi.org/10.3390/molecules24010163
WHO (2014) Antimicrobial resistance. Global Report on Surveillance. Bull World Health Organ 61:383–394. https://doi.org/10.1007/s13312-014-0374-3
Wingender J, Flemming HC (2011) Biofilms in drinking water and their role as reservoir for pathogens. Int J Hyg Environ Health 214:417–423. https://doi.org/10.1016/j.ijheh.2011.05.009
Wright MS, Peltier GL, Stepanauskas R, McArthur JV (2006) Bacterial tolerances to metals and antibiotics in metal-contaminated and reference streams. FEMS Microbiol Ecol 58:293–302. https://doi.org/10.1111/j.1574-6941.2006.00154.x
Xi C, Zhang Y, Marrs CF, Ye W, Simon C, Foxman B, Nriagu J (2009) Prevalence of antibiotic resistance in drinking water treatment and distribution systems. Appl Environ Microbiol 75:5714–5718. https://doi.org/10.1128/AEM.00382-09
Xiao W, Hong S, Tang Z, Seal S, Taylor JS (2007) Effects of blending on surface characteristics of copper corrosion products in drinking water distribution systems. Corros Sci 49:449–468. https://doi.org/10.1016/j.corsci.2006.04.018
Xie Y, Giammar DE (2011) Effects of flow and water chemistry on lead release rates from pipe scales. Water Res 45:6525–6534. https://doi.org/10.1016/j.watres.2011.09.050
Xie Y, Wang Y, Singhal V, Giammar DE (2010) Effects of pH and carbonate concentration on dissolution rates of the lead corrosion product PbO2. Environ Sci Technol 44:1093–1099. https://doi.org/10.1021/es9026198
Xu L, Ouyang W, Qian Y, Su C, Su J, Chen H (2016) High-throughput profiling of antibiotic resistance genes in drinking water treatment plants and distribution systems. Environ Pollut 213:119–126. https://doi.org/10.1016/j.envpol.2016.02.013
Yang F, Shi B, Gu J, Wang D, Yang M (2012) Morphological and physicochemical characteristics of iron corrosion scales formed under different water source histories in a drinking water distribution system. Water Res 46:5423–5433. https://doi.org/10.1016/j.watres.2012.07.031
Yang Y, Liu G, Song W, Ye C, Lin H, Li Z, Liu W (2019) Plastics in the marine environment are reservoirs for antibiotic and metal resistance genes. Environ Int 123:79–86. https://doi.org/10.1016/j.envint.2018.11.061
Zhang J, Li W, Chen J, Wang F, Qi W, Li Y (2019a) Impact of disinfectant on bacterial antibiotic resistance transfer between biofilm and tap water in a simulated distribution network. Environ Pollut 246:131–140. https://doi.org/10.1016/j.envpol.2018.11.077
Zhang K, Xin R, Zhao Z, Ma Y, Zhang Y, Niu Z (2020) Antibiotic resistance genes in drinking water of China: occurrence, distribution and influencing factors. Ecotoxicol Environ Saf 188:109837. https://doi.org/10.1016/j.ecoenv.2019.109837
Zhang M, Chen L, Ye C, Yu X (2018a) Co-selection of antibiotic resistance via copper shock loading on bacteria from a drinking water bio-filter. Environ Pollut 233:132–141. https://doi.org/10.1016/j.envpol.2017.09.084
Zhang S, Wang Y, Song H, Lu J, Yuan Z, Guo J (2019b) Copper nanoparticles and copper ions promote horizontal transfer of plasmid-mediated multi-antibiotic resistance genes across bacterial genera. Environ Int 129:478–487. https://doi.org/10.1016/j.envint.2019.05.054
Zhang Y, Griffin A, Edwards M (2008) Nitrification in premise plumbing: role of phosphate, pH and pipe corrosion. Environ Sci Technol 42:4280–4284. https://doi.org/10.1021/es702483d
Zhang Y, Gu AZ, Cen T, Li X, He M, Li D, Chen J (2018b) Sub-inhibitory concentrations of heavy metals facilitate the horizontal transfer of plasmid-mediated antibiotic resistance genes in water environment. Environ Pollut 237:74–82. https://doi.org/10.1016/j.envpol.2018.01.032
Zhang Y, Gu AZ, He M, Li D, Chen J (2017) Subinhibitory concentrations of disinfectants promote the horizontal transfer of multidrug resistance genes within and across genera. Environ Sci Technol 51(1):570–580. https://doi.org/10.1021/acs.est.6b03132
Zhang Y, Gu AZ, Xie S, Li X, Cen T, Li D, Chen J (2018c) Nano-metal oxides induce antimicrobial resistance via radical-mediated mutagenesis. Environ Int 121:1162–1171. https://doi.org/10.1016/j.envint.2018.10.030
Zhang Y, Love N, Edwards M (2009) Nitrification in drinking water systems. Crit Rev Environ Sci Technol 39:153–208
Zhou X, Shen Y, Fu X, Wu F (2018) Application of sodium silicate enhances cucumber resistance to Fusarium wilt and alters soil microbial communities. Front Plant Sci 9:1–12. https://doi.org/10.3389/fpls.2018.00624
Zhu Y, Wang H, Li X, Hu C, Yang M, Qu J (2014) Characterization of biofilm and corrosion of cast iron pipes in drinking water distribution system with UV/Cl2disinfection. Water Res 60:174–181. https://doi.org/10.1016/j.watres.2014.04.035
Zlatanović L, van der Hoek JP, Vreeburg JHG (2017) An experimental study on the influence of water stagnation and temperature change on water quality in a full-scale domestic drinking water system. Water Res 123:761–772. https://doi.org/10.1016/j.watres.2017.07.019
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LK was funded by the Arthur J. Schmitt Fellowship and the Marquette University Water Quality Center.
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L.K. and P.M. contributed to the study conception and design. Literature review, data collection, and analysis were performed by LK. The first draft of the manuscript was written by LK and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Kimbell, L.K., Wang, Y. & McNamara, P.J. The impact of metal pipe materials, corrosion products, and corrosion inhibitors on antibiotic resistance in drinking water distribution systems. Appl Microbiol Biotechnol 104, 7673–7688 (2020). https://doi.org/10.1007/s00253-020-10777-8
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DOI: https://doi.org/10.1007/s00253-020-10777-8