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Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials

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Abstract

This article reviews mushrooms with anti-breast cancer activity. The mushrooms covered which are better known include the following: button mushroom Agaricus bisporus, Brazilian mushroom Agaricus blazei, Amauroderma rugosum, stout camphor fungus Antrodia camphorata, Jew’s ear (black) fungus or black wood ear fungus Auricularia auricula–judae, reishi mushroom or Lingzhi Ganoderma lucidum, Ganoderma sinense, maitake mushroom or sheep’s head mushroom Grifola frondosa, lion’s mane mushroom or monkey head mushroom Hericium erinaceum, brown beech mushroom Hypsizigus marmoreus, sulfur polypore mushroom Laetiporus sulphureus, Lentinula edodes (shiitake mushroom), Phellinus linteus (Japanese “meshimakobu,” Chinese “song gen,” Korean “sanghwang,” American “black hoof mushroom”), abalone mushroom Pleurotus abalonus, king oyster mushroom Pleurotus eryngii, oyster mushroom Pleurotus ostreatus, tuckahoe or Fu Ling Poria cocos, and split gill mushroom Schizophyllum commune. Antineoplastic effectiveness in human clinical trials and mechanism of anticancer action have been reported for Antrodia camphorata, Cordyceps sinensis, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes.

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Acknowledgments

We gratefully acknowledge the award of HMRF research grant (No. 12131221) from the Food and Health Bureau, the Government of Hong Kong Special Administrative Region, and a grant from the National Natural Science Foundation of China (No. 81471927). We are thankful for support of the science and technology project of the Science and Technology Innovation Commission of Shenzhen (No. JCYJ20170818094217688) and the discipline construction project of biochemistry and molecular biology from the National Development and Reform Commission (85629-000001 and 1452).

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Correspondence to Jack Ho Wong, Tzi Bun Ng, Helen Hei Ling Chan, Chunman Li or Lixin Xia.

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This work does not contain any studies with human participants or animals performed by any of the authors.

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The authors declare that they have no conflict of interest.

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Wong, J.H., Ng, T.B., Chan, H.H.L. et al. Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials. Appl Microbiol Biotechnol 104, 4675–4703 (2020). https://doi.org/10.1007/s00253-020-10476-4

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  • DOI: https://doi.org/10.1007/s00253-020-10476-4

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