Abstract
Scientific community has made a lot of efforts to combat the infectious diseases using antimicrobial agents, but these are associated with problems of development of multi-drug resistance and their adverse side effects. To tackle these challenges, nanocarrier-based drug delivery system using polysaccharides has received enormous attention in the past few years. These antimicrobial agents can become more efficacious when adsorbed, entrapped, or linked to polysaccharides. In addition, these nanocarrier-based systems provide an increase in the surface area of the drug and are able to achieve the targeted drug delivery as well as used for the synthesis of packaging materials with improved mechanical strength, barrier, and antimicrobial properties. This review focuses on potential therapeutic applications of nanocarrier-based drug delivery systems using polysaccharides for antimicrobial applications.
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References
Abdel-Halim ES, Al-Deyab SS (2014) Antimicrobial activity of silver/starch/polyacrylamide nanocomposite. Int J Biol Macromol 68:33–38. doi:10.1016/j.ijbiomac.2014.04.025
Abdel-Mohsen AM, Hrdina R, Burgert L, Abdel-Rahman RM, Hasova M, Smejkalova D, Kolar M, Pekar M, Aly AS (2013) Antibacterial activity and cell viability of hyaluronan fiber with silver nanoparticles. Carbohydr Polym 92:1177–1187. doi:10.1016/j.carbpol.2012.08.098
An J, Ji Z, Wang D, Luo Q, Li X (2014) Preparation and characterization of uniform-sized chitosan/silver microspheres with antibacterial activities. Mater Sci Eng C 36:33–41. doi:10.1016/j.msec.2013.11.037
Aranaz I, Mengibar M, Harris R, Panos I, Miralles B, Acosta N, Galed G, Heras A (2009) Functional characterization of chitin and chitosan. Curr Chem Biol 3:203–230. doi:10.2174/187231309788166415
Arora D, Dhanwal V, Nayak D, Saneja A, Amin H, Rasool ur R, Gupta PN, Goswami A (2016) Preparation, characterization and toxicological investigation of copper loaded chitosan nanoparticles in human embryonic kidney HEK-293 cells. Mater Sci Eng C 61:227–234. doi:10.1016/j.msec.2015.12.035
Aziz MA, Cabral JD, Brooks HJL, Moratti SC, Hanton LR (2012) Antimicrobial properties of a chitosan dextran-based hydrogel for surgical use. Antimicrob Agents Chemother 56:280–287. doi:10.1128/AAC.05463-11
Azizi S, Ahmad MBH, Hussein MZ, Ibrahim NA (2013) Synthesis, antibacterial and thermal studies of cellulose nanocrystal stabilized ZnO-Ag heterostructure nanoparticles. Molecules 18:6269–6280. doi:10.3390/molecules18066269
Baier G, Cavallaro A, Vasilev K, Mailander V, Musyanovych A, Landfester K (2013) Enzyme responsive hyaluronic acid nanocapsules containing polyhexanide and their exposure to bacteria to prevent infection. Biomacromol 14:1103–1112. doi:10.1021/bm302003m
Balachandran YL, Girija S, Selvakumar R, Tongpim S, Gutleb AC, Suriyanarayanan S (2013) Differently environment stable bio-silver nanoparticles: study on their optical enhancing and antibacterial properties. PLoS One 8:e77043. doi:10.1371/journal.pone.0077043
Bankura KP, Maity D, Mollick MMR, Mondal D, Bhowmick B, Bain MK, Chakraborty A, Sarkar J, Acharya K, Chattopadhyay D (2012) Synthesis, characterization and antimicrobial activity of dextran stabilized silver nanoparticles in aqueous medium. Carbohydr Polym 89:1159–1165. doi:10.1016/j.carbpol.2012.03.089
Bansal J, Kedige SD, Anand S (2010) Hyaluronic acid: a promising mediator for periodontal regeneration. Ind J Dent Res 21:575–578. doi:10.4103/0970-9290.74232
Bayarri M, Oulahal N, Degraeve P, Gharsallaoui A (2014) Properties of lysozyme/low methoxyl (LM) pectin complexes for antimicrobial edible food packaging. J Food Eng 131:18–25. doi:10.1016/j.jfoodeng.2014.01.013
Bordes P, Pollet E, Averous L (2009) Nano-biocomposites: biodegradable polyester/nanoclay systems. Prog Polym Sci 34:125–155. doi:10.1016/j.progpolymsci.2008.10.002
Cabedo L, Luis Feijoo J, Pilar Villanueva M, Lagaron JM, Gimenez E (2006) Optimization of biodegradable nanocomposites based on PLA/PCL blends for food packaging applications. Macromol Symp 233:191–197. doi:10.1002/masy.200690017
Cai J, Kimura S, Wada M, Kuga S (2009) Nanoporous cellulose as metal nanoparticles support. Biomacromol 10:87–94. doi:10.1021/bm800919e
Carpenter BL, Feese E, Sadeghifar H, Argyropoulos DS, Ghiladi RA (2012) Porphyrin-cellulose nanocrystals: a photobactericidal material that exhibits broad spectrum antimicrobial activity. Photochem Photobiol 88:527–536. doi:10.1111/j.1751-1097.2012.01117.x
Chang Y, McLandsborough L, McClements DJ (2011) Physicochemical properties and antimicrobial efficacy of electrostatic complexes based on cationic ε-polylysine and anionic pectin. J Agricul Food Chem 59:6776–6782. doi:10.1021/jf201162g
Chen CP, Chen CT, Tsai T (2012) Chitosan nanoparticles for antimicrobial photodynamic inactivation: characterization and in vitro investigation. Photochem Photobiol 88:570–576. doi:10.1111/j.1751-1097.2012.01101.x
Chudobova D, Nejdl L, Gumulec J, Krystofova O, Rodrigo MAM, Kynicky J, Ruttkay-Nedecky B, Kopel P, Babula P, Adam V (2013) Complexes of silver(I) ions and silver phosphate nanoparticles with hyaluronic acid and/or chitosan as promising antimicrobial agents for vascular grafts. Int J Mol Sci 14:13592–13614. doi:10.3390/ijms140713592
Coseri S, Spatareanu A, Sacarescu L, Rimbu C, Suteu D, Spirk S, Harabagiu V (2015) Green synthesis of the silver nanoparticles mediated by pullulan and 6-carboxypullulan. Carbohydr Polym 116:9–17. doi:10.1016/j.carbpol.2014.06.008
Diaz-Visurraga J, Daza C, Pozo C, Becerra A, von Plessing C, Garcia A (2012) Study on antibacterial alginate-stabilized copper nanoparticles by FT-IR and 2D-IR correlation spectroscopy. Int J Nanomedicine 7:3597–3612. doi:10.2147/IJN.S32648
Dandekar P, Jain R, Stauner T, Loretz B, Koch M, Wenz G, Lehr C-M (2012) A hydrophobic starch polymer for nanoparticle-mediated delivery of docetaxel. Macromol Biosci 12:184–194. doi:10.1002/mabi.201100244
De Cicco F, Porta A, Sansone F, Aquino RP, Del Gaudio P (2014a) Nanospray technology for an in situ gelling nanoparticulate powder as a wound dressing. Int J Pharm 473:30–37. doi:10.1016/j.ijpharm.2014.06.049
De Cicco F, Reverchon E, Adami R, Auriemma G, Russo P, Calabrese EC, Porta A, Aquino RP, Del Gaudio P (2014b) In situ forming antibacterial dextran blend hydrogel for wound dressing: SAA technology vs. spray drying. Carbohydr Polym 101:1216–1224. doi:10.1016/j.carbpol.2013.10.067
Dong C, Ye Y, Qian L, Zhao G, He B, Xiao H (2014a) Antibacterial modification of cellulose fibers by grafting β-cyclodextrin and inclusion with ciprofloxacin. Cellulose 21:1921–1932. doi:10.1007/s10570-014-0249-8
Dong Y-Y, Deng F, Zhao J-J, He J, Ma M-G, Xu F, Sun R-C (2014b) Environmentally friendly ultrasound synthesis and antibacterial activity of cellulose/Ag/AgCl hybrids. Carbohydr Polym 99:166–172. doi:10.1016/j.carbpol.2013.08.023
Du W-L, Niu S-S, Xu Y-L, Xu Z-R, Fan C-L (2009) Antibacterial activity of chitosan tripolyphosphate nanoparticles loaded with various metal ions. Carbohydr Polym 75:385–389. doi:10.1016/j.carbpol.2008.07.039
Eghbalifam N, Frounchi M, Dadbin S (2015) Antibacterial silver nanoparticles in polyvinyl alcohol/sodium alginate blend produced by gamma irradiation. Int J Biol Macromol 80:170–176. doi:10.1016/j.ijbiomac.2015.06.042
Ehivet FE, Min B, Park M-K, Oh J-H (2011) Characterization and antimicrobial activity of sweet potato starch-based edible film containing origanum (Thymus capitatus) oil. J Food Sci 76:C178–C184. doi:10.1111/j.1750-3841.2010.01961.x
Feese E, Sadeghifar H, Gracz HS, Argyropoulos DS, Ghiladi RA (2011) Photobactericidal porphyrin-cellulose nanocrystals: synthesis, characterization, and antimicrobial properties. Biomacromol 12:3528–3539. doi:10.1021/bm200718s
Friedman AJ, Phan J, Schairer DO, Champer J, Qin M, Pirouz A, Blecher-Paz K, Oren A, Liu PT, Modlin RL (2013) Antimicrobial and anti-inflammatory activity of chitosan-alginate nanoparticles: a targeted therapy for cutaneous pathogens. J Invest Dermatol 133:1231–1239. doi:10.1038/jid.2012.399
Galvan Marquez I, Akuaku J, Cruz I, Cheetham J, Golshani A, Smith ML (2013) Disruption of protein synthesis as antifungal mode of action by chitosan. Int J Food Microbiol 164:108–112. doi:10.1016/j.ijfoodmicro.2013.03.025
Gnanadhas DP, Thomas MB, Elango M, Raichur AM, Chakravortty D (2013) Chitosan-dextran sulphate nanocapsule drug delivery system as an effective therapeutic against intraphagosomal pathogen Salmonella. J Antimicrob Chemother:dkt252. doi:10.1093/jac/dkt252
Gong Y, Han G, Zhang Y, Pan Y, Li X, Xia Y, Wu Y (2012) Antifungal activity and cytotoxicity of zinc, calcium, or copper alginate fibers. Biol Trace Elem Res 148:415–419. doi:10.1007/s12011-012-9388-7
Gopi D, Kanimozhi K, Kavitha L (2015) Opuntia ficus-indica peel derived pectin mediated hydroxyapatite nanoparticles: synthesis, spectral characterization, biological and antimicrobial activities. Spectrochimica Acta Part A: Mol Biomol Spectroscopy 141:135–143. doi:10.1016/j.saa.2015.01.039
Grumezescu AM, Andronescu E, Holban AM, Ficai A, Ficai D, Voicu G, Grumezescu V, Balaure PC, Chifiriuc CM (2014) Water dispersible cross-linked magnetic chitosan beads for increasing the antimicrobial efficiency of aminoglycoside antibiotics. Int J Pharm 454:233–240. doi:10.1016/j.ijpharm.2013.06.054
Hebeish AA, Ramadan MA, Montaser AS, Farag AM (2014) Preparation, characterization and antibacterial activity of chitosan-g-poly acrylonitrile/silver nanocomposite. Int J Biol Macromol 68:178–184. doi:10.1016/j.ijbiomac.2014.04.028
Honarkar H, Barikani M (2009) Applications of biopolymers I: chitosan. Monatshefte fur Chemie 140:1403–1420
Hu Y, Du Y, Yang J, Kennedy JF, Wang X, Wang L (2007) Synthesis, characterization and antibacterial activity of guanidinylated chitosan. Carbohydr Polym 67:66–72. doi:10.1016/j.carbpol.2006.04.015
Hussein-Al-Ali SH, El Zowalaty ME, Hussein MZ, Ismail M, Webster TJ (2014) Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic. Int J Nanomedicine 9:549–558. doi:10.2147/IJN.S53079
Islan GA, Mukherjee A, Castro GR (2015) Development of biopolymer nanocomposite for silver nanoparticles and ciprofloxacin controlled release. Int J Biol Macromol 72:740–750. doi:10.1016/j.ijbiomac.2014.09.020
Jayaramudu T, Raghavendra GM, Varaprasad K, Sadiku R, Ramam K, Raju KM (2013) Iota-carrageenan-based biodegradable Ag0 nanocomposite hydrogels for the inactivation of bacteria. Carbohydr Polym 95:188–194. doi:10.1016/j.carbpol.2013.02.075
Jung R, Kim Y, Kim H-S, Jin H-J (2009) Antimicrobial properties of hydrated cellulose membranes with silver nanoparticles. J Biomater Sci Polymer Edition 20:311–324. doi:10.1163/156856209X412182
Kanmani P, Lim ST (2013) Synthesis and characterization of pullulan-mediated silver nanoparticles and its antimicrobial activities. Carbohydr Polym 97:421–428. doi:10.1016/j.carbpol.2013.04.048
Kara F, Aksoy EA, Yuksekdag Z, Hasirci N, Aksoy S (2014) Synthesis and surface modification of polyurethanes with chitosan for antibacterial properties. Carbohydr Polym 112:39–47. doi:10.1016/j.carbpol.2014.05.019
Kiruthika V, Maya S, Suresh MK, Kumar VA, Jayakumar R, Biswas R (2015) Comparative efficacy of chloramphenicol loaded chondroitin sulfate and dextran sulfate nanoparticles to treat intracellular Salmonella infections. Colloids Surf B Biointerfaces 127:33–40. doi:10.1016/j.colsurfb.2015.01.012
Koga H, Tokunaga E, Hidaka M, Umemura Y, Saito T, Isogai A, Kitaoka T (2010) Topochemical synthesis and catalysis of metal nanoparticles exposed on crystalline cellulose nanofibers. Chem Commun 46:8567–8569. doi:10.1039/c0cc02754e
Kumari A, Yadav SK, Yadav SC (2010) Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf B Biointerfaces 75:1–18. doi:10.1016/j.colsurfb.2009.09.001
Kuorwel KK, Cran MJ, Sonneveld K, Miltz J, Bigger SW (2011) Antimicrobial activity of natural agents coated on starch-based films against Staphylococcus aureus. J Food Science 76:M531–M537. doi:10.1111/j.1750-3841.2011.02344.x
Lee MY, Yang JA, Jung HS, Beack S, Choi JE, Hur W, Koo H, Kim K, Yoon SK, Hahn SK (2012) Hyaluronic acid-gold nanoparticle/interferon α complex for targeted treatment of hepatitis C virus infection. ACS Nano 6:9522–9531. doi:10.1021/nn302538y
Lee SJ, Heo DN, Moon JH, Ko WK, Lee JB, Bae MS, Park SW, Kim JE, Lee DH, Kim EC (2014) Electrospun chitosan nanofibers with controlled levels of silver nanoparticles. Preparation, characterization and antibacterial activity. Carbohydr Polym 111:530–537. doi:10.1016/j.carbpol.2014.04.026
Lequeux I, Ducasse E, Jouenne T, Thebault P (2014) Addition of antimicrobial properties to hyaluronic acid by grafting of antimicrobial peptide. Eur Polym J 51:182–190. doi:10.1016/j.eurpolymj.2013.11.012
Li Q, Ren J, Dong F, Feng Y, Gu G, Guo Z (2013) Synthesis and antifungal activity of thiadiazole-functionalized chitosan derivatives. Carbohydr Res 373:103–107. doi:10.1016/j.carres.2013.03.001
Llorens A, Lloret E, Picouet P, Fernandez A (2012) Study of the antifungal potential of novel cellulose/copper composites as absorbent materials for fruit juices. Int J Food Microbiol 158:113–119. doi:10.1016/j.ijfoodmicro.2012.07.004
Luckachan GE, Pillai CKS (2011) Biodegradable polymers-a review on recent trends and emerging perspectives. J Polym Environ 19:637–676. doi:10.1007/s10924-011-0317-1
Luo J, Xie M, Wang X (2014) Green fabrication of quaternized chitosan/rectorite/Ag NP nanocomposites with antimicrobial activity. Biomed Mater 9:011001. doi:10.1088/1748-6041/9/1/011001
Malzahn K, Jamieson WD, Droge M, Mailander V, Jenkins ATA, Weiss CK, Landfester K (2014) Advanced dextran based nanogels for fighting Staphylococcus aureus infections by sustained zinc release. J Mater Chem B 2:2175–2183. doi:10.1039/C3TB21335H
Mandal SM, Porto WF, De D, Phule A, Korpole S, Ghosh AK, Roy SK, Franco OL (2014) Screening of serine protease inhibitors with antimicrobial activity using iron oxide nanoparticles functionalized with dextran conjugated trypsin and in silico analyses of bacterial serine protease inhibition. Analyst 139:464–472. doi:10.1039/c3an01132a
Martinez A, Fernandez A, Perez E, Benito M, Teijon JM, Blanco MD (2012) Polysaccharide-based nanoparticles for controlled release formulations. In: Hashim AA (ed) Dr. The delivery of nanoparticles, InTech, pp. 185–222. doi:10.5772/34156
Mohamed RR, Sabaa MW (2014) Synthesis and characterization of antimicrobial crosslinked carboxymethyl chitosan nanoparticles loaded with silver. Int J Biol Macromol 69:95–99. doi:10.1016/j.ijbiomac.2014.05.025
Mohanty S, Mishra S, Jena P, Jacob B, Sarkar B, Sonawane A (2012) An investigation on the antibacterial, cytotoxic, and antibiofilm efficacy of starch-stabilized silver nanoparticles. Nanomed Nanotechnol Biol Med 8:916–924. doi:10.1016/j.nano.2011.11.007
Montanari E, D’Arrigo G, Di Meo C, Virga A, Coviello T, Passariello C, Matricardi P (2014) Chasing bacteria within the cells using levofloxacin-loaded hyaluronic acid nanohydrogels. Eur J Pharm Biopharm 87(3):518–523. doi:10.1016/j.ejpb.2014.03.003
Morais DS, Rodrigues MA, Lopes MA, Coelho MJ, Mauricio AC, Gomes R, Amorim I, Ferraz MP, Santos JD, Botelho CM (2013) Biological evaluation of alginate-based hydrogels, with antimicrobial features by Ce (III) incorporation, as vehicles for a bone substitute. J Mater Sci Mater Med 24:2145–2155. doi:10.1007/s10856-013-4971-9
Moritz S, Wiegand C, Wesarg F, Hessler N, Muller FA, Kralisch D, Hipler UC, Fischer D (2014) Active wound dressings based on bacterial nanocellulose as drug delivery system for octenidine. Int J Pharm 471:45–55. doi:10.1016/j.ijpharm.2014.04.062
Morsy MK, Khalaf HH, Sharoba AM, El-Tanahi HH, Cutter CN (2014) Incorporation of essential oils and nanoparticles in pullulan films to control foodborne pathogens on meat and poultry products. J Food Sci 79:M675–M684. doi:10.1111/1750-3841.12400
Muraleedaran K, Mujeeb VMA (2015) Applications of chitosan powder with in situ synthesized Nano ZnO particles as an antimicrobial agent. Int J Biol Macromol 77:266–272. doi:10.1016/j.ijbiomac.2015.03.058
Ornelas-Megiatto C, Shah PN, Wich PR, Cohen JL, Tagaev JA, Smolen JA, Wright BD, Panzner MJ, Youngs WJ, Frechet JMJ (2012) Aerosolized antimicrobial agents based on degradable dextran nanoparticles loaded with silver carbene complexes. Mol Pharm 9:3012–3022. doi:10.1021/mp3004379
Otari SV, Patil RM, Waghmare SR, Ghosh SJ, Pawar SH (2013) A novel microbial synthesis of catalytically active Ag-alginate biohydrogel and its antimicrobial activity. Dalton Trans 42:9966–9975. doi:10.1039/c3dt51093j
Park SY, Chung JW, Priestley RD, Kwak S-Y (2012) Covalent assembly of metal nanoparticles on cellulose fabric and its antimicrobial activity. Cellulose 19:2141–2151. doi:10.1007/s10570-012-9773-6
Pour ZS, Makvandi P, Ghaemy M (2015) Performance properties and antibacterial activity of crosslinked films of quaternary ammonium modified starch and poly (vinyl alcohol). Int J Biol Macromol 80:596–604. doi:10.1016/j.ijbiomac.2015.07.008
Priya B, Gupta VK, Pathania D, Singha AS (2014) Synthesis, characterization and antibacterial activity of biodegradable starch/PVA composite films reinforced with cellulosic fibre. Carbohydr Polym 109:171–179. doi:10.1016/j.carbpol.2014.03.044
Rajan P, Nair D, Kumar CS, Dusanapudi LN (2013) Hyaluronic acid-a simple, unusual polysaccharide: a potential mediator for periodontal regeneration. Uni Res J Dent 3:113–119. doi:10.4103/2249-9725.123973
Rhim J-W, Wang L-F (2013) Mechanical and water barrier properties of agar/k-carrageenan/konjac glucomannan ternary blend biohydrogel films. Carbohydr Polym 96:71–81. doi:10.1016/j.carbpol.2013.03.083
Sahoo D, Sahoo S, Mohanty P, Sasmal S, Nayak PL (2009) Chitosan: a new versatile bio-polymer for various applications. Design Monom Polym 12:377–404. doi:10.1163/138577209X12486896623418
Shady SF, Gaines P, Garhwal R, Leahy C, Ellis E, Crawford K, Schmidt DF, McCarthy SP (2013) Synthesis and characterization of pullulan-polycaprolactone core-shell nanospheres encapsulated with ciprofloxacin. J Biomed Nanotechnol 9:1644–1655. doi:10.1166/jbn.2013.1654
Shah AA, Hasan F, Hameed A, Ahmed S (2008) Biological degradation of plastics: a comprehensive review. Biotechnol Adv 26:246–265. doi:10.1016/j.biotechadv.2007.12.005
Shalumon KT, Anulekha KH, Nair SV, Nair SV, Chennazhi KP, Jayakumar R (2011) Sodium alginate/poly (vinyl alcohol)/nano ZnO composite nanofibers for antibacterial wound dressings. Int J Biol Macromol 49:247–254. doi:10.1016/j.ijbiomac.2011.04.005
Shankar R, Samykutty A, Riggin C, Kannan S, Wenzel U, Kolhatkar R (2013) Cathepsin B degradable star shaped peptidic macromolecules for delivery of 2-methoxyestradiol. Mol Pharm 10:3776–3788. doi:10.1021/mp400261h
Shankar S, Reddy JP, Rhim J-W, Kim H-Y (2015) Preparation, characterization, and antimicrobial activity of chitin nanofibrils reinforced carrageenan nanocomposite films. Carbohydr Polym 117:468–475. doi:10.1016/j.carbpol.2014.10.010
Shojaee-Aliabadi S, Mohammadifar MA, Hosseini H, Mohammadi A, Ghasemlou M, Hosseini SM, Haghshenas M, Khaksar R (2014) Characterization of nanobiocomposite kappa-carrageenan film with Zataria multiflora essential oil and nanoclay. Int J Biol Macromol 69:282–289. doi:10.1016/j.ijbiomac.2014.05.015
Singh R, Singh D (2012) Radiation synthesis of PVP/alginate hydrogel containing nanosilver as wound dressing. J Mater Sci Mater Med 23:2649–2658. doi:10.1007/s10856-012-4730-3
Singh RS, Saini GK, Kennedy JF (2008) Pullulan: microbial sources, production and applications. Carbohydr Polym 73:515–531. doi:10.1016/j.carbpol.2008.01.003
Son WK, Youk JH, Lee TS, Park WH (2004) Preparation of antimicrobial ultrafine cellulose acetate fibers with silver nanoparticles. Macromol Rapid Commun 25:1632–1637. doi:10.1002/marc.200400323
Szymonska J, Targosz-Korecka M, Krok F (2009) Characterization of starch nanoparticles. J Phys Conf Ser 146:012027. doi:10.1088/1742-6596/146/1/012027
Thomas SF, Rooks P, Rudin F, Atkinson S, Goddard P, Bransgrove R, Mason PT, Allen MJ (2014) The bactericidal effect of dendritic copper microparticles, contained in an alginate matrix, on Escherichia coli. PLoS One 9:e96225. doi:10.1371/journal.pone.0096225
Torchilin VP (2012) Multifunctional nanocarriers. Adv Drug Deliv Rev 64:302–315. doi:10.1016/j.addr.2012.09.031
Tripathi S, Mehrotra GK, Dutta PK (2011) Chitosan-silver oxide nanocomposite film: preparation and antimicrobial activity. Bulletin Mater Sci 34:29–35. doi:10.1007/s12034-011-0032-5
Uchida K, Otake K, Inoue M, Koike Y, Matsushita K, Tanaka K, Inoue Y, Mohri Y, Kusunoki M (2011) Bacteriostatic effects of hyaluronan-based bioresorbable membrane. Surg Sci 2:431–436. doi:10.4236/ss.2011.29094
Unnithan AR, Barakat NAM, Tirupathi Pichiah PB, Gnanasekaran G, Nirmala R, Cha YS, Jung CH, El-Newehy M, Kim HY (2012) Wound-dressing materials with antibacterial activity from electrospun polyurethane-dextran nanofiber mats containing ciprofloxacin HCl. Carbohydr Polym 90:1786–1793. doi:10.1016/j.carbpol.2012.07.071
Vimala K, Yallapu MM, Varaprasad K, Reddy NN, Ravindra S, Naidu NS, Raju KM (2010) Fabrication of curcumin encapsulated chitosan-PVA silver nanocomposite films for improved antimicrobial activity. J Biomater Nanobiotechnol 2:55–64. doi:10.4236/jbnb.2011.21008
Wang Q, Perez JM, Webster TJ (2013) Inhibited growth of Pseudomonas aeruginosa by dextran-and polyacrylic acid-coated ceria nanoparticles. Int J Nanomedicine 8:3395–3399. doi:10.2147/IJN.S50292
Wright GD (2010) Antibiotic resistance in the environment: a link to the clinic? Curr Opin Microbiol 13:589–594. doi:10.1016/j.mib.2010.08.005
Wu Y, Long Y, Li Q-L, Han S, Ma J, Yang Y-W, Gao H (2015) Layer-by-layer (LBL) self-assembled biohybrid nanomaterials for efficient antibacterial applications. ACS Appl Mater Interfaces 7(3):17255–17263. doi:10.1021/acsami.5b04216
Yang J-A, Park K, Jung H, Kim H, Hong SW, Yoon SK, Hahn SK (2011) Target specific hyaluronic acid-interferon alpha conjugate for the treatment of hepatitis C virus infection. Biomater 32:8722–8729. doi:10.1016/j.biomaterials.2011.07.088
Zaki NM, Hafez MM (2012) Enhanced antibacterial effect of ceftriaxone sodium-loaded chitosan nanoparticles against intracellular Salmonella typhimurium. AAPS Pharm Sci Tech 13:411–421. doi:10.1208/s12249-012-9758-7
Zhang L, Li R, Dong F, Tian A, Li Z, Dai Y (2015) Physical, mechanical and antimicrobial properties of starch films incorporated with ε-poly-L-lysine. Food Chem 166:107–114. doi:10.1016/j.foodchem.2014.06.008
Zhao L, Zhu B, Jia Y, Hou W, Su C (2013) Preparation of biocompatible carboxymethyl chitosan nanoparticles for delivery of antibiotic drug. BioMed Res Int 2013:236469. doi:10.1155/2013/236469
Zhao X, Xia Y, Li Q, Ma X, Quan F, Geng C, Han Z (2014) Microwave-assisted synthesis of silver nanoparticles using sodium alginate and their antibacterial activity. Colloids Surf A Physicochem Eng Asp 444:180–188. doi:10.1016/j.colsurfa.2013.12.008
Zhong T, Oporto GS, Jaczynski J, Jiang C (2015) Nanofibrillated cellulose and copper nanoparticles embedded in polyvinyl alcohol films for antimicrobial applications. BioMed Res Int 2015:456834. doi:10.1155/2015/456834
Zhou B, Hu Y, Li J, Li B (2014) Chitosan/phosvitin antibacterial films fabricated via layer-by-layer deposition. Int J Biol Macromol 64:402–408. doi:10.1016/j.ijbiomac.2013.12.016
Zhou W, Wang Y, Jian J, Song S (2013) Self-aggregated nanoparticles based on amphiphilic poly (lactic acid)-grafted-chitosan copolymer for ocular delivery of amphotericin B. Int J Nanomedicine 8:3715–3728. doi:10.2147/IJN.S51186
Acknowledgments
The authors thank the Council of Scientific and Industrial Research (CSIR), New Delhi (BSC-0117), for the financial assistance, IIIM communication no. IIIM/1868/2015. DA, NS, and VS gratefully acknowledge the Council of Scientific and Industrial Research (CSIR) and ICMR for providing Senior Research Fellowship. The authors also wish to acknowledge Mr. Ankit Saneja for providing the necessary support in the preparation of this manuscript.
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Arora, D., Sharma, N., Sharma, V. et al. An update on polysaccharide-based nanomaterials for antimicrobial applications. Appl Microbiol Biotechnol 100, 2603–2615 (2016). https://doi.org/10.1007/s00253-016-7315-0
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DOI: https://doi.org/10.1007/s00253-016-7315-0