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Effect of shear stress on cultivation of Bacillus thuringiensis for thuringiensin production

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Abstract.

Cultivation of Bacillus thuringiensis for thuringiensin production is a mixed-growth-associated system. Cultivation conditions should be different during the cell growth stage and production stage. In this study, agitation speed and aeration rate were varied during the exponential growth phase and stationary phase in order to investigate the effect of shear stress via agitation on cultivation of B. thuringiensis for thuringiensin production. It was found that shear stress had a significant effect on thuringiensin production during the stationary phase. By decreasing the agitation speed during the stationary phase, product formation was increased up to 43%.

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Authors and Affiliations

  1. Department of Chemical Engineering, National Tsing Hua University, Hsinchu 30043, Taiwan, , , , ,

    W.-T. Wu,  Y.-L. Hsu,  Y.-F. Ko &  L.-L. Yao

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  1. W.-T. Wu
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  2. Y.-L. Hsu
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  3. Y.-F. Ko
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  4. L.-L. Yao
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Received revision: 11 August 2001

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Wu, .WT., Hsu, .YL., Ko, .YF. et al. Effect of shear stress on cultivation of Bacillus thuringiensis for thuringiensin production. Appl Microbiol Biotechnol 58, 175–177 (2002). https://doi.org/10.1007/s00253-001-0827-1

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  • DOI: https://doi.org/10.1007/s00253-001-0827-1

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